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  药店国别: 西班牙药房
产地国家: 西班牙
所属类别: 心血管系统药物->抗血栓药物
处方药:处方药
包装规格: 10毫克/片 28片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
MEDA PHARMA SAU
生产厂家英文名:
MEDA PHARMA SAU
该药品相关信息网址1:
http://www.netdoctor.co.uk/medicines/100002826.html
该药品相关信息网址2:
http://www.drugs.com/uk/zanidip-10-mg-and-20-mg-tablets-1451.html
原产地英文商品名:
Lercadip(Generic Equivalent to Zanidip) 10mg/tab 28tabs/box
原产地英文药品名:
Lercanidipine hydrochloride
中文参考商品译名:
乐卡地平(再宁平仿制药) 10毫克/片 28片/盒
中文参考药品译名:
盐酸乐卡地平
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
hypertension
临床试验期:
完成
中文适应病症参考翻译1:
高血压
药品信息:

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 详细处方信息以本药内容附件PDF文件(20117601222523.pdf、20117601223513.PDF)的“原文Priscribing Information”为准
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部分中文乐卡地平处方资料(仅供参考)

乐卡地平
药物名称:
乐卡地平

药物别名:再宁平 Lerdip,Zanidip,Masnidipine

英文名称:lercanidipine

功用作用:在欧洲本品用于各型高血压;在英国只用于轻中度高血压。
 
用法用量:推荐剂量为10mg,qd,至少在饭前15min口服,必要时2周以后增至20mg

注意事项:本品耐受性良性,据20个临床试验中心、共约1800例患者参与的试验结果表明,不良反应发生率为11.8%,安慰剂组为7%。

最常见不良反应:头痛、面约、无力、疲劳、心悸及踝关节水肿,约3%~5%患者因此而停药。对9605例临床观察表明,本品耐受性良性,其中7469例轻中度高血压患者口服10或20mg·d-1,疗程3个月,不良反应发生率7.6%,最常见的是头痛(2.7%)和踝关节水肿(2.1%)。本品不良反应多属于轻中度,且与血管扩张作用相关。
对二氢吡啶类过敏者禁用;左心室传出通道阻滞、未经治疗的充血性心力衰竭、不稳定型心绞痛、有严重肾脏或肝脏疾病、以及在一个月内发生过心肌梗塞的患者禁用;妊娠和哺乳期妇女,未采取任何避孕措施的高龄妇女 ;18岁以下患者不得服用禁用。
本品生物利用度不受年龄和肝硬化的影响,但严重肝、肾功能不全者禁用。本品与药酶抑制剂,如酮康唑、依曲康唑、红霉素、氟西汀;或药酶诱导剂如苯妥英、依曲康唑、红霉素、氟西汀;及药酶底物如特非那定、阿司咪唑、环孢素、胺碘酮、奎尼丁、地西泮、咪达唑仑、普萘洛尔和美托洛尔合用时应谨慎。此外,本品也不能与葡萄柚汁合用,以免因血药浓度升高而产生不良反应。

Zanidip (lercanidipine)
Main use:High blood pressure
Active ingredient:Lercanidipine hydrochloride
Manufacturer:Recordati Pharmaceuticals Limited

How does it work?
Zanidip tablets contain the active ingredient lercanidipine hydrochloride, which is a type of medicine called a calcium channel blocker. Lercanidipine is also available without a brand name, ie as the generic medicine.

Lercanidipine works by slowing the movement of calcium through the muscle cells that are found in the walls of blood vessels. It does this by blocking 'calcium channels' in these muscle cells. Calcium is needed by muscle cells so that they can contract. Lercanidipine reduces the amount of calcium available to muscle cells and so makes them relax.

Lercanidipine acts specifically on the muscle cells in the walls of arteries, causing them to relax. This allows the arteries in the body to widen.

The relaxing and widening of the small arteries in the body decreases the resistance that the heart has to push against in order to pump the blood around the body. This reduces the pressure within the blood vessels. Lercanidipine can therefore be used to lower high blood pressure.

Lercanidipine can also have a widening effect on the small arteries in the heart, which improves the supply of blood, and therefore the oxygen to the heart. This reduces the effort the heart has to make to pump blood around the body.

What is it used for?
High blood pressure (hypertension).

Warning!
Dizziness and weariness may occasionally occur during treatment with blood pressure lowering medicines. If you are affected, you should take extra care when driving or operating machinery.
You should not drink grapefruit juice while you are taking this medicine, as it can increase the level of isradipine in your blood. This could increase its effect on your blood pressure and make you feel dizzy, and could also increase the risk of experiencing other side effects.

Use with caution in
Elderly people.
Chronic heart failure.
Sick sinus syndrome, a problem common in the elderly, that affects the heart.
Decreased kidney function.
Decreased liver function.
Narrowing of the main artery coming from the heart (aortic stenosis).
Not to be used in
Allergy to other related calcium channel blockers (dihydropyridines), eg nifedipine, amlodipine.
Children or adolescents under 18 years of age.
Heart failure
Angina that is increasing in severity, duration or frequency (unstable angina).
People who are having a heart attack or who have had a heart attack in the last month.
Failure of the heart to maintain adequate circulation of blood (cardiogenic shock).
Pregnancy.
Breastfeeding.
Hereditary blood disorders called porphyrias.
Zanidip tablets contain lactose and are not suitable for people with rare hereditary problems of galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek further medical advice from your doctor.
This medicine may pass into breast milk in small amounts. The effect on a nursing infant is not known. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek further medical advice from your doctor.

Label warnings
Take this medication half to one hour before food.

Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.

Uncommon (affect between 1 in 100 and 1 in 1000 people)
Dizziness.
Headache.
Flushing.
Swollen ankles, wrists, arms or legs.
Faster than normal heart beat (tachycardia).
Awareness of your heart beat (heart palpitations).

Rare (affect between 1 in 1000 and 1 in 10,000 people)
Skin rash.
Fatigue.
Drowsiness.
Increased need to pass urine (polyuria).
Disturbances of the gut, such as nausea, vomiting, diarrhoea, abdominal pain and indigestion.
Difficulty in breathing (dyspnoea).
A general feeling of being unwell (malaise).
Chest pain.

Very rare (affect less than 1 in 10,000 people)
Alteration in results of liver function tests.
Mild swelling of the gums (gingival hyperplasia).
Increased urinary frequency.
Hypotension.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.

Lercanidipine may have an additive effect with other medicines that decrease blood pressure, particularly other medicines used to treat high blood pressure (antihypertensives). If the combination of medicines lowers your blood pressure too much it could make you feel dizzy. If this happens to you, you should sit or lie down until the symptoms pass. If you frequently feel dizzy when taking lercanidipine in combination with other medicines that can lower blood pressure you should let your doctor know, as your doses may need adjusting. Other medicines that can decrease blood pressure include the following:
ACE inhibitors, eg enalapril
alpha-blockers such as prazosin
alprostadil
angiotensin II receptor antagonists such as losartan
antipsychotics
benzodiazepines, eg temazepam, diazepam
baclofen
beta-blockers such as propranolol , metoprolol
other calcium-channel blockers, eg verapamil, nifedipine
clonidine
diazoxide
diuretics, eg furosemide, bendroflumethiazide
dopamine agonists, eg bromocriptine, apomorphine
hydralazine
levodopa
MAOI antidepressants, eg phenelzine
methyldopa
minoxidil
moxisylyte
moxonidine
nicorandil
nitrates, eg glyceryl trinitrate (GTN)
tizanidine.

The following medicines may increase the breakdown of lercanidipine by the liver, which could make it less effective:
carbamazepine
phenobarbital
phenytoin
primidone
rifampicin
the herbal remedy St John's wort (Hypericum perforatum).

These medicines should be avoided whilst taking lercanidipine.

The following medicines may decrease the breakdown of lercanidipine by the liver, which could increase the risk of its side effects:
clarithromycin
erythromycin
itraconazole
ketoconazole
protease inhibitors for HIV infection, eg ritonavir, nelfinavir, saquinavir
telithromycin.

Cimetidine may increase the blood level of lercanidipine and therefore increases the risk of its side effects. It is important that your blood pressure is closely montiored if you are taking this medicine together with cimetidine.

Lercanidipine may increase the blood level of the immunosuppressant medicine ciclosporin. The use of these medicines together should be avoided.

Other medicines containing the same active ingredients
Lercanidipine tablets are also available without a brand name, ie as the generic medicine.

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 详细处方信息以本药内容附件PDF文件(20117601332914.pdf、20117601330222.PDF)的“原文Priscribing Information”为准
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更新日期: 2013-03-05
附件:
20117601332914.PDF    

20117601330222.PDF    

 
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