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  药店国别: 美国药房
产地国家: 美国
所属类别: 作用于消化系统药物->治疗肠道疾病
处方药:处方药
包装规格: 250毫克/胶囊 240胶囊/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
希尔制药
生产厂家英文名:
SHIRE
该药品相关信息网址1:
www.pentasaus.com/
该药品相关信息网址2:
www.drugs.com/pentasa.html
该药品相关信息网址3:
www.rxlist.com/pentasa-drug.htm
原产地英文商品名:
PENTASA ER CAPSULE SA 250MG/CAP 240CAPS/BOTTLE
原产地英文药品名:
MESALAMINE
中文参考商品译名:
颇得斯安缓释胶囊 250毫克/胶囊 240胶囊/瓶
中文参考药品译名:
美沙拉嗪
中文参考化合物名称:
5-氨基水杨酸
原产地国家批准上市年份:
1993/05/10
英文适应病症1:
Ulcerative Colitis
英文适应病症2:
Ulcerative proctitis
英文适应病症3:
Crohn's disease
临床试验期:
完成
中文适应病症参考翻译1:
溃疡性结肠炎
中文适应病症参考翻译2:
溃疡性直肠炎
中文适应病症参考翻译3:
克隆氏病
药品信息:

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 详细处方信息以本药内容附件PDF文件(201271123125037.PDF)的“原文Priscribing Information”为准
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 部分中文颇得斯安处方资料(仅供参考)

颇得斯安 【Pentasa】
【分类】
消化系统用药/止泻药

【别名】美沙拉嗪,5-氨基水杨酸,艾迪莎,颇得斯安

【外文名】Mesalazine,5-AminoSalicylicAcid,Pentasa,Etiasa

【药理作用及用途】对肠壁的炎症有显著的抑制作用;美沙拉嗪可以抑制引起炎症的前列腺素的合成和炎性介质白三烯的形成,从而对肠粘膜的炎症起显著抑制作用。对有炎症的肠壁的结缔组织效果更佳。用于溃疡性结肠炎、溃疡性直肠炎和克隆氏病(Crohn'sDisease)。

【用法及用量】片剂:成人①溃疡性结肠炎:1.0/次;4次/日,维持治疗剂量为0.5/次;3次/日 医学 教育网搜集整理 。②克隆氏病:1.0/次;3~4次/日儿童:每日20~30mg/kg。栓剂:成人:1个/次;1~2个/日。儿童:两岁可以考虑使用,具体剂量遵医嘱。

【不良反应】可能出现轻度的胃部不适。

【注意事项】①对水杨酸类药物以及本品的赋形剂过敏者忌用。②肝肾功能不全者慎用;妊娠及哺乳期妇女慎用;两岁以下儿童不宜用。③与氰钴胺片(VitB12片)同有,将影响氰钴胺片的吸收。④服药时要整粒囫囵吞服,绝不可嚼碎或压碎。

【规格】片剂:0.5g栓剂:1.0/支

All About Pentasa ( mesalamine )
Many patients are not as well-informed about prescription medications as they ought to be. We believe that the more you know about your medications, the better. Therefore, we have written this to explain more about Pentasa and to explain the importance of taking it properly. If any of this information causes you concern or if you want additional information about your medicine and its use, please check with your doctor or pharmacist. Remember to keep all prescription drugs beyond the sight and reach of children when not in use. Store all drugs in their original labeled containers; the place of storage should be cool, dry, and away from light. Always read the label before each use.

What is Pentasa?
Doctors have been using the drug, Azulfidine, for over 50 years to treat inflammatory bowel disease. In some ways the Azulfidine molecule is half aspirin-like and half like the antibiotic sulfa. Some patients have an adverse reaction to Azulfidine, mostly due to its similarity to sulfa compounds. Scientists were able to remove the sulfa-like portion of Azulfidine, while maintaining the full beneficial effect. The result was meslamine, an aspirin-like antiinflammatory drug. Approved by the FDA in 1987, mesalamine comes in different formulations and delivery systems - one of which is named Pentasa.

Pentasa is a man-made compound that is taken by mouth to treat inflammatory disorders of the colon such as Crohn's disease, and other inflammatory conditions. It is sometimes given in conjunction with other medications such as the steroid, prednisone. Another common name for mesalamine is 5-aminosalicylic acid, or 5-ASA. Each capsule of Pentasa contains about 250 mg of mesalamine. The shelf life is 3 years.

Targeted Delivery
One of the unique features of Pentasa is the fact that the pill does not release its medication until it reaches the diseased area. Each tablet has a special plastic coating which delays release of mesalamine until the tablets reach the end of the 20 feet of small intestine, or the ileum. This allows delivery of most of the medicine right where the problem lies - the ileum and right colon. How mesalamine works is unknown, but it appears to be topical rather than systemic. Once released in the colon, mesalamine is minimally absorbed. Most of it works directly on the lining of the ileum and colon - like putting a salve on a rash. Eventually most of it is excreted with the stool. Studies have shown that Pentasa can help bring a case of Crohn's under control and help maintain a remission over time. Realize that inflammatory bowel disease rarely goes into permanent remission, but the risk of flare-ups can be substantially reduced by continued use of Pentasa at the maintenance dose as directed by your doctor.

What Pentasa is not.
Pentasa is not a steroid like prednisone. It is not habit forming; it does not cause drowsiness. Since it lacks the sulfa-like properties of Azulfidine, most patients intolerant or allergic to Azulfidine and other sulfa drugs can be safely treated with Pentasa. In addition, Pentasa does not reduce a man's sperm count as does Azulfidine. There are no known interactions with other medications. As yet, there is no generic substitution available.

How does Pentasa differ from Asacol
Both Pentasa and Asacol are prescription forms of mesalamine. The difference between Asacol and Pentasa is in the outer chemical coating. Oral Pentasa has a unique formulation. The active ingredient is contained in coated microgranules, which enables a prolonged release of the active substance throughout the intestinal tract, from duodenum to the rectum. Therefore the Pentasa preparation is more useful for Crohn's patients who often have inflammation of the small intestine. The average small bowel transit time is approximately 3-4 hours in healthy volunteers.

Asacol is a delayed release enteric-coated tablets which generally releases the active ingredient only in the colon. While there are always clinical exceptions, Asacol is generally suitable for patients with colitis only (ulcerative colitis or Crohn's colitis), but not disease involving the small intestine.

Taking Pentasa properly
1. Swallow Pentasa tablets whole, taking care not to break the outer coating. It is important that you do not break or crush them. The outer coating is designed to remain intact, to protect the active ingredient until it reaches the end of the small intestine, where the tablet coating dissolves and the contents of the tablet are released directly into the ileum and colon. Pentasa is usually taken four times a day with food.
2. Take the dose as prescribed. There is no fixed rule for the correct dose of Pentasa. Each case is different, but the usual daily adult dose is 4 capsules taken all at once 4 times a day for a total of 16 capsules per day. Your doctor will determine what dose is best for you on the basis of your age, weight, the activity of your disease, and any other medical conditions that you may have. Do not alter the prescribed dosage on your own. Your doctor will routinely reassess the optimal dose for you. As the disease goes into remission, the dose is sometimes reduced to 4 tablets twice a day.
3. Do not skip doses. There is no harm in an occasional missed dose. If you do miss a dose, simply skip the missed dose and then go back to your regular dosing schedule. Do not intentionally double doses.
4. Do not stop taking this medication on your own. Typically, Pentasa is prescribed for long-term treatment of inflammatory bowel disease. Not only does Pentasa help reduce the symptoms of an acute attack, but it also helps to reduce the risk of future attacks. Stopping this medication may trigger another flare up of intestinal inflammation and make you ill. Only stop Pentasa under your doctor's supervision.
5. Patients may sometimes notice what looks like small beads or partially intact tablets in the stool, particularly during times of severe diarrhea. These are just the empty shells that are left after the medicine has been absorbed into the body.

What are the side effects?
All medicines - even those purchased without a prescription - may sometimes produce unwanted side effects. Millions of prescriptions have been written for Pentasa in the United States and Canada and it has been generally well tolerated. Adverse events seen in clinical trials with Pentasa tablets have generally been mild and reversible, and have seldom resulted in discontinuation of treatment.

These side effects should be reported to your doctor:
* Persistent headaches
* Skin rash, severe itching
* Unexplained fever
* Unusual bleeding or bruising
* Unexplained skin blistering and peeling

The following side effects usually do not require medical attention. They often will go away as your body becomes used to the medication. However, if they continue or are bothersome, check with your doctor:
* Mild Headache
* Upset stomach, heartburn
* Nausea and vomiting
* Dizziness

Some patients may experience side effects not listed above. If you notice any other symptoms, simply consult your doctor, nurse, or pharmacist.

Limiting side effects
You can help limit side effects by taking Pentasa exactly as prescribed and by reporting any problems promptly to your doctor. Drink plenty of fluids.

Drug Interactions
There are no known drug interactions with any of the mesalamine products.

Precautions
Do not take Pentasa if you are allergic to aspirin or have untreated peptic ulcer disease. Inform your doctor if you are pregnant, planning to become pregnant soon, or breast-feeding. Mesalamine has not been studied in pregnant women. However, mesalamine has not been shown to cause birth defects or other problems in animal studies. Mesalamine may pass into the breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Remember
Pentasa is a powerful drug that can be of tremendous benefit to you. As with all medications, however, side effects may occur. You can best limit problems with this medication by taking it exactly as prescribed. If you have any questions or concerns, please do not hesitate to discuss them with your doctor.

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 详细处方信息以本药内容附件PDF文件(201271123125037.PDF)的“原文Priscribing Information”为准
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更新日期: 2012-7-12
附件:




201271123125037.PDF    

 
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