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  药店国别: 美国药房
产地国家: 美国
所属类别: 影响血液及造血系统药物->止血药
处方药:处方药
包装规格: 250微克/毫升/安醅/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
法玛西亚-普强
生产厂家英文名:
PHARMACIA AND UPJOHN
该药品相关信息网址1:
http://www.drugs.com/mtm/hemabate.html
该药品相关信息网址2:
http://www.rxlist.com/hemabate-drug.htm
原产地英文商品名:
HEMABATE 250mcg/ml/Ampul/vial
原产地英文药品名:
CARBOPROST TROMETHAMINE
中文参考商品译名:
欣母沛 250微克/毫升/安醅/瓶
中文参考药品译名:
卡前列素氨丁三醇
原产地国家批准上市年份:
1979/01/09
英文适应病症1:
Postpartum hemorrhage
英文适应病症2:
Uterine atony
临床试验期:
完成
中文适应病症参考翻译1:
产后出血
中文适应病症参考翻译2:
子宫迟缓
药品信息:

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 详细处方信息以本药内容附件PDF文件(20096200233133.pdf)的“原文Priscribing Information”为准
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部分中文Hemabate处方资料(仅供参考)

【英文名称】CarboprostTromethamine

【别名】欣母沛。Hemabate。

【用法用量】
(1)流产和适应症1~4项:起始剂量为1ml欣母沛无菌溶液(含相当于250ug的卡前列素),用结核菌注射器做深部肌肉注射。此后依子宫反应,间隔1.5至3.5小时再次注射250ug的剂量。开始时亦可使用选择性的测试剂量100ug(0.4ml)。数次注射250ug(1ml)剂量后子宫收缩力仍不足时,剂量可增至500ug(2ml)。卡前列素氨丁三醇的总剂量不得超过12mg,且不建议连续使用超过两天以上。
(2)难治性产后子宫出血:起始剂量为250ug欣母沛无菌溶液(1ml欣母沛),做深部肌肉注射。临床实验显示,大部分成功的病例(73%)对单次注射即有反应。然而在某些选择性的病例中,间隔15至90分钟多次注射,也可得到良好的疗效。而注射次数和间隔的需要,应由专职医师根据病情而定,总剂量不得超过2mg(8次剂量)。

【功能主治】适用于妊娠期为13周至20周的流产,此妊娠期从正常末次月经的第一天算起,亦适用于下述与中期流产有关的情况:
1.其他方法不能将胎儿排出;
2.采用宫内方法时,由于胎膜早破导致药物流失,子宫收缩乏力;
3.需要进行子宫内药物重复滴注的流产;
4.尚无生存活力的胎儿出现意外的或自发性胎膜早破,但无力将胎儿排出。适用于常规处理方法无效的子宫收缩弛缓引起的产后出血现象。

【副作用】欣母沛无菌溶液的副作用一般为暂时性的,治疗结束后可恢复。最常见的不良反应多与它对平滑肌的收缩作用有关。试验患者中约2/3表现出呕吐和腹泻,1/3有恶心,1/8体温上升超过2℉,1/4出现潮红。

【注意事项】对欣母沛无菌溶液过敏的患者;急性盆腔炎的患者;有活动性心肺肾肝疾病的患者禁用。欣母沛无菌溶液与其他强力缩宫剂一样,必须严格遵循推荐剂量使用。
 
Hemabate
Generic Name: carboprost (KAR boe prost)
Brand Names: Hemabate

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What is Hemabate (carboprost)?
Carboprost is a form of prostaglandin (a hormone-like substance that occurs naturally in the body). Prostaglandins help to control functions in the body such as blood pressure and muscle contractions.

Carboprost is used to treat severe bleeding after childbirth (postpartum).

Carboprost is also used to produce an abortion by causing uterine contractions. It is usually given between the 13th and 20th weeks of pregnancy, but may be given at other times for medical reasons. Carboprost is often used when another method of abortion has not completely emptied the uterus, or when a complication of pregnancy would cause the baby to be born too early to survive.

Carboprost may also be used for other purposes not listed in this medication guide.

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What is the most important information I should know about Hemabate (carboprost)?
Carboprost usually causes nausea, vomiting, and/or diarrhea. You may be given to control these things before you are given carboprost.

You should not receive this medication if you are allergic to carboprost, or have certain conditions such as pelvic inflammatory disease, a breathing disorder, heart disease, liver disease, or kidney disease. Serious side effects of carboprost may include severe pelvic cramping, vaginal bleeding, high fever, and severe vomiting or diarrhea.

Before you receive carboprost, tell your doctor if you have been treated with any other drugs that may cause contractions of the uterus. Carboprost can increase the effects of these other drugs, and they should not be used together.

Your cervix (opening of the uterus) will need to be checked after you receive carboprost. Do not miss any scheduled follow-up visits to your doctor.

In some cases, carboprost may not produce a complete abortion and the procedure must be repeated.

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What should I discuss with my health care provider before receiving Hemabate (carboprost)?
You should not receive this medication if you are allergic to carboprost, or have certain conditions. Tell your doctor if you have:
pelvic inflammatory disease;
a lung disorder or breathing problem;
heart disease;
kidney disease; or
liver disease.

Before receiving carboprost, tell your doctor if you are allergic to any drugs, or if you have:
high or low blood pressure;
diabetes;
epilepsy or other seizure disorder;
any scarring in your uterus;
a history of asthma; or
a history of heart, kidney, or liver disease.

If you have any of these conditions, you may not be able to receive carboprost, or you may need dosage adjustments or special tests during treatment.

If you are receiving this medication for purposes other than abortion or postpartum bleeding, tell your doctor if you are pregnant.

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How is carboprost given?
Carboprost is given as an injection into a muscle. You will receive this injection in a clinic or hospital setting.

You may also be given medication to control nausea, vomiting, or diarrhea caused by carboprost.

To be sure this medication has been effective, your cervix (opening of the uterus) will need to be checked after the procedure. Do not miss any scheduled follow-up visits to your doctor.

In some cases, carboprost may not produce a complete abortion and the procedure must be repeated.

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What happens if I miss a dose?
Since this medication is given as needed by a healthcare professional, it is not likely that you will miss a dose.

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What happens if I overdose?
Tell your caregivers right away if you think you have received too much of this medicine. An overdose of carboprost is unlikely to occur in a hospital or clinic setting.

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What should I avoid while receiving Hemabate (carboprost)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity after you receive carboprost.

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Hemabate (carboprost) side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
severe pelvic pain, cramping, or vaginal bleeding;
high fever;
feeling light-headed or short of breath;
severe nausea, vomiting, or diarrhea; or
increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure).

Less serious side effects include:
mild fever that may come and go;
chills, numbness, or tingly feeling;
mild nausea or diarrhea;
cough;
headache;
breast pain or tenderness;
menstrual type pain; or
ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Hemabate (carboprost)?
Before you receive carboprost, tell your doctor if you have been treated with any other drugs that may cause contractions of the uterus, such as:
dinoprostone (Prostin E2);
mifepristone (Mifeprex (RU-486)
misoprostol (Cytotec); or
oxytocin (Pitocin).

Carboprost can increase the effects of these other drugs, and they should not be used together.

This list it not complete and there may be other drugs that can affect carboprost. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

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Where can I get more information?
Your doctor or pharmacist can provide more information about carboprost.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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 详细处方信息以本药内容附件PDF文件(20096200233133.pdf)的“原文Priscribing Information”为准
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2011年4月14日更新

更新日期: 2011-4-14
附件:




20096200233133.pdf    

 
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