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  药店国别: 美国药房
产地国家: 美国
所属类别: 妇科药物->不孕症
处方药:处方药
包装规格: 250微克/0.5毫升/注射器 5注射器/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
ORGANON USA INC
生产厂家英文名:
ORGANON USA INC
该药品相关信息网址1:
http://www.drugs.com/mtm/antagon.html
该药品相关信息网址2:
http://www.rxlist.com/ganirelix-drug.htm
该药品相关信息网址3:
http://www.emedicinehealth.com/drug-ganirelix/article_em.htm
原产地英文商品名:
GANIRELIX ACETATE (FORMERLY ANTAGON) 250MCG/0.5ML/DISP SYRINGE 5DISP SYRINGE/BOX
原产地英文药品名:
GANIRELIX ACETATE
中文参考商品译名:
醋酸加尼瑞克(以前名称为ANTAGON) 250微克/0.5毫升/注射器 5注射器/盒
中文参考药品译名:
醋酸加尼瑞克
原产地国家批准上市年份:
1999/07/29
英文适应病症1:
Infertility
临床试验期:
完成
中文适应病症参考翻译1:
不孕症
药品信息:

友情提示:Ganirelix Acetate就是目前代替Antagon品牌药的现在品牌药。

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 详细处方信息以本药内容附件PDF文件(201221623420221.pdf)的“原文Priscribing Information”为准
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部分中文加尼瑞克处方资料(仅供参考)

中文名称:醋酸加尼瑞克

英文名称:Ganirelix Acetate

英文别名:Ganirelix acetate; D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N(sup 6)-((ethylamino)(ethylimino)methyl)-D-lysyl-L-leucyl-N(sup 6)-((ethylamino)(ethylimino)methyl)-L-lysyl-L-prolyl-, diacetate (salt); Ganirelix acetate injection; N-Acetyl-3-(2-naphthyl)-D-alanyl-p-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N(sup 6)-(N,N'-diethylamidino)-D-lysyl-L-leucyl-N(sup 6)-(N,N'-diethylamidino)-L-lysyl-L-prolyl-D-alaninamide diacetate (salt); UNII-56U7906FQW

功效主治:治疗妇女不孕症(人工取卵、受精、植入)。

药理作用:醋酸加尼瑞克是一合成的与内源性促性腺素释放素(GnRH)(又称促黄体生成素释放素,LHRH)类似的十肽化合物,是GnRH的拮抗剂。本品竞争性拮抗促性腺的GnRH受休,从而变异途径,引起快速、可逆性地抑制促性腺激素(黄体生成素LH和促卵泡激素FSH)分泌。其抑制垂体分泌LH比抑制分泌FSH更显著,从而降低性激素的产生。通过抑制中周期GnRH对LH诱导波动,本品能够抑制排卵、卵母细胞成熟分裂和黄体化。对患卵巢过度刺激症妇女,本品能够预防LH波动及相关刺激,并提高植入和妊娠比率。本品从大鼠垂体LHRH受体处取代放射性125I标记过的亮丙瑞林的pKi值为10.78,因此与受体结合力是LHRH的2倍。在培养大鼠垂体细胞中,本品竞争性抑制亮丙瑞林诱导LH释放的pA2值为11.37。在实验中,1μg本品能抑制90%大鼠排卵,2μg则100%抑制。而0.5μg本品抑制50%排卵。本品在发情完盛期雌性大鼠中的半数有效剂量ED50值为1.4μg/kg。本品在培养大鼠乳腺细胞诱导组胺释放的半数有效浓度EC50值为5.3~11μg/ml,而亮丙瑞林的对应值为1.8μg/ml,说明本品作为组胺释放诱导剂其能力弱6倍。更重要的是,在麻醉的雄性大鼠,通过低血压效应评价体内过敏性样能力跟早期LHRH拮抗剂值(20~40μg/kgiv)相比,本品非常小(ED50=0.9mg/kgiv),具有非常良好的抗促性腺激素与过敏性样能力。本品作为一个LHRH拮抗剂被当作FSH在试管受精(IVF)或胞质内精子注射前来控制卵巢刺激,对卵母细胞形态学和质量影响进行了评价。在卵巢刺激病人,用本品或LHRH拮抗剂亮丙瑞林的对应值为1.8μg/ml,说明本品作为组胺释放诱导剂其能力弱6倍。更重要的是,在麻醉的雄性大鼠,通过低血压效应评价体内过敏性样能力跟早期LHRH拮抗剂值(20~40μg/kgiv)相比,本品非常小(ED50=0.9mg/kgiv),具有非常良好的抗促性腺激素与过敏性样能力。 本品作为一个LHRH拮抗剂被当作FSH在试管受精(IVF)或胞质内精子注射前来控制卵巢刺激,对卵母细胞形态学和质量影响进行了评价。在卵巢刺激病人,用本品或LHRH拮抗剂亮丙瑞林治疗发现在核酸成熟、卵质形态学、卵膜弹性、受精及分裂率两者没有差别,并且具有足够质量适合转移的胚胎数量也是相同的。

不良反应:中性细胞增多(≥8.3/mm3)、腹痛、胎儿死亡、头痛、卵巢过度刺激综合征、阴道出血、恶心。

用法用量:皮下注射,1次/d,每次0.25mg。

注意事项:对本品GnRH及其同类物过敏者,情孕或怀疑怀孕者禁用。本品必须在临床医师指导下应用。由于本品具有抗促性腺激素性质可导致流产。本品是否分布在母乳中未知,哺乳妇女不宜应用。对65岁以上老人无足够临床资料。

What happens if I miss a dose (Antagon, Ganirelix Acetate)?
Call your doctor for instructions if you miss a dose.

What happens if I overdose (Antagon, Ganirelix Acetate)?
Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a ganirelix overdose are not known.

What should I avoid while using ganirelix (Antagon, Ganirelix Acetate)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect ganirelix (Antagon, Ganirelix Acetate)?
There may be other drugs that can interact with ganirelix. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?
Your pharmacist can provide more information about ganirelix.

What should I discuss with my healthcare provider before using ganirelix (Antagon, Ganirelix Acetate)?

You should not use this medication if you are allergic to ganirelix or similar medications such as leuprolide (Lupron, Eligard), goserelin (Zoladex), or nafarelin (Synarel).

Before using ganirelix, tell your doctor if you are allergic to latex rubber.

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use ganirelix if you are already pregnant. Your doctor may give you a pregnancy test to make sure you are not pregnant before you receive ganirelix. Tell your doctor right away if you become pregnant during treatment.

It is not known whether ganirelix passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ganirelix (Antagon, Ganirelix Acetate)?
Ganirelix is given as an injection under the skin. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Ganirelix is usually given once daily for several days in a row during certain phases of your fertility treatment cycle. Follow your doctor's instructions and try not to miss any doses.

Each single-use prefilled syringe of this medicine is for one use only. Throw away the vial after one use, even if there is still some medicine left in it after injecting your dose.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

During your treatment with ganirelix, your blood may need to be tested often. Do not miss any follow-up visits to your doctor. You must remain under the care of your doctor while using ganirelix.

Store the ganirelix prefilled syringe at room temperature, away from heat, moisture and light.

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 详细处方信息以本药内容附件PDF文件(201221623420221.pdf)的“原文Priscribing Information”为准
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更新日期: 2013-12-22
附件:
201221623420221.PDF    

 
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