温馨提醒：该药品为管制药！

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 详细处方信息以本药内容附件PDF文件（2011112421040325.pdf）的“原文Priscribing Information”为准
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部分中文多培沙明处方资料（仅供参考）

多培沙明(Dopexamine)
[又名]Dopexamino，Dopacard．

[药效学]本品是一种新合成的儿茶酚胺类药物化学结构与多巴胺相似，有很强的β2肾上腺素能受体兴奋作用，但对多巴胺DA1和DA2受体，以及β1肾上腺素能受体的兴奋作用较弱；尚能抑制神经元对儿茶酚胺的摄取。本品的正性频率作用和正性肌力作用是通过药物间接兴奋β1肾上腺素能受体，提高压力感受器的反射活性，抑制去甲肾上腺素的再摄取，以及直接兴奋心脏β2肾上腺素能受体而产生的。本品还能增加肾脏、心肌和骨骼肌的血流量。

[临床应用]适用于急性心衰和心脏手术后心输出量低的病人。

[药动学]单剂量给健康者以1.4μg／kg．min的速度静脉滴注本品，血药浓度成比例上升，1h后峰浓度可达124μg／L；静滴结束后，血药浓度迅速下降，消除半衰期为7min，血浆清除率为36ml／kg．min；组织分布广泛，本品经邻位甲基化后再与硫酸产生结合，进而代谢成两个主要的代谢物，代谢物及原形药物从尿和粪中排泄，尿中排泄呈双相，终末相半衰期为4d；服用本品后12d，尿和粪中的排泄量仍分别占原剂量的50％和20%以上。

[毒副作用]主要有恶心、呕吐、心动过速、胸痛、心绞痛、心室性异位节律和震颤等，且在剂量减少和滴注结束时迅即发生。

[禁忌症]血小板减少症患者禁用；缺血性心脏病患者慎用；由于本品的拟交感活性，高血糖和低血钾患者也慎用。

[用法用量]静滴：用于急性心衰和心脏手术后需改善血液动力学的患者，静脉滴注开始以0．5μg／kg．min，以后可根据血液动力学变化，增加到1．0μg／kg．min，最高可达6．0μg／kg．min。

[制剂]注射剂：50mg：5ml／支。

DOPACARD® 50 mg/5 ml
Concentrate for Solution for Infusion
(Dopexamine hydrochloride as a 1% solution w/v)

PACKAGE LEAFLET: INFORMATION FOR THE USER
Read all of this leaflet carefully before you start taking this medicine.
•Keep this leaflet. You may need to read it again.
•If you have any further questions, ask your doctor or pharmacist.
•This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
•If any of the side effects get serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

1. WHAT DOPACARD IS AND WHAT IT IS USED FOR
The name of this medicine is DOPACARD 50 mg/5 ml Concentrate for Solution for Infusion. The active ingredient in this medicine is dopexamine hydrochloride which belongs to a group of medicines called sympathomimetics.

DOPACARD is used to widen your blood vessels and allow your heart to pump blood easily to your vital organs, such as kidneys or liver.

It is also used as a supportive treatment during times when your heart is not pumping blood around your body properly.

2. BEFORE YOU ARE GIVEN DOPACARD
You should not be given DOPACARD if you:
•Are allergic (hypersensitive) to dopexamine hydrochloride or any of the other ingredients of DOPACARD.
•Are taking, or have recently taken, medicines for depression called monoamine oxidase inhibitors (MAOI).
•Have a disorder of the adrenal glands which causes you to have high blood pressure (phaeochromocytoma).
•Have a blood disorder that affects the number of platelets in your blood (thrombocytopenia).
•Have any heart problems (for example, a partially blocked artery).

DOPACARD is not suitable for use in children.

Take special care with DOPACARD if you:
•Have very low blood pressure.
•Have been told by your doctor you have poor blood circulation.
•Have recently had any chest pains or if you have a history of chest pain.
•Have ever had a heart attack.
•Have any condition which can affect your blood sugar level e.g. diabetes

If any of the above apply to you, you should speak to your doctor before taking this medicine.

Taking other medicines
Please tell your doctor if you are taking or have recently taken other medicines, including medicines obtained without a prescription. This is especially important if you are taking any of the following:
•Water tablets (diuretics)
•Medicines for a heart condition e.g. digoxin
•Beta-blockers e.g. atenolol
•Medicines for nausea and sickness e.g. prochlorperazine
•Noradrenaline or dopamine

Pregnancy and breast-feeding
DOPACARD is not recommended for use during pregnancy and breast-feeding. If you are pregnant, think you might be pregnant, or are breast-feeding tell your doctor or pharmacist before being given DOPACARD.

3. HOW DOPACARD WILL BE GIVEN
Your doctor will ensure you have sufficient fluid circulating in your body before giving DOPACARD.

The doctor or other health care professional will make up the correct dose of DOPACARD for you and it will be given as a solution by a slow injection or by a drip into a vein (infusion), for a maximum of 48 hours.

Your doctor will monitor your response to DOPACARD.

If you are given too much DOPACARD
It is unlikely you will be given too much DOPACARD, but if this happens your doctor will treat any symptoms that may occur.

4. POSSIBLE SIDE EFFECTS
Like all medicines, DOPACARD can cause sides effects, although not everybody gets them. The following side effects have been reported:
•Racing or irregular pulse.
•Slow pulse.
•High or low blood pressure.
•Worsening heart failure.
•Heart attack.
•Chest pain (angina).
•Nausea and vomiting.
•Shortness of breath.
•Sweating.
•Headaches.
•Shaking.

Rarely redness and soreness may occur at the site where the drip enters the vein.

More rarely, there have been reports of the following side effects being experienced by patients who have been given DOPACARD while undergoing heart surgery, although these may have been due to the condition of the patient:
•Kidney failure.
•Severe breathing difficulties.
•Fluid on the lungs.
•Blood poisoning.
•Bleeding.

If you experience any side effects while receiving DOPACARD tell your doctor or health care professional immediately.

5. HOW TO STORE DOPACARD
Keep all medicines out of the reach and sight of children.

Keep the ampoule in the outer carton.

DOPACARD must not be used after the expiry date printed on the ampoule.

6. FURTHER INFORMATION
What DOPACARD contains
DOPACARD contains 5 ml of 1% dopexamine hydrochloride as the active substance.

It also contains disodium edetate, hydrochloric acid and water for injections as the inactive ingredients.

What DOPACARD looks like and contents of the pack
DOPACARD comes in boxes of 10 clear glass ampoules each containing 5 ml 1% w/w solution of dopexamine hydrochloride.

Marketing Authorisation Holder
Cephalon UK Limited
1 Albany Place
Hyde Way
Welwyn Garden City
Hertfordshire
AL7 3BT
UK

Manufacturer
Hospira S.p.A.
Via Fosse Ardeatine 2
20060 Liscate (MI)
Italy

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 详细处方信息以本药内容附件PDF文件（2011112421040325.pdf）的“原文Priscribing Information”为准
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