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 详细处方信息以本药内容附件PDF文件（201052622070136.pdf）的“原文Priscribing Information”为准
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部分中文Doryx处方资料（仅供参考）
 

【别名】盐酸多西环素 、脱氧土霉素、强力霉素

【外文名】Doxycycline HCI, Doxitard, Liomycin

【成分】 盐酸多西环素

【适应症】
立克次体病，肺炎支原体感染，衣原体感染，回归热，霍乱，布氏杆菌病，杜克雷嗜血杆菌病，鼠疫，兔热病，巴尔通氏体病，也可用于对青霉素过敏的梅毒、雅司病、淋病患者。

【用量用法】
成人及８岁以上儿童（体重＞50kg)第一天每12hr服50mg或100mg qd,8岁以上儿童（体重＜50kg)2 mg/kg体重／日，分2次口服。

【禁忌】对四环素类药物过敏者、孕妇及哺乳妇女。

【不良反应】
牙齿变色、牙釉质发育不良，胃肠道反应如恶心、呕吐、腹痛、腹泻、厌食、食管炎、食管溃疡，肝脏损害，皮疹。

【注意事项】肝病患者和肾功能损害者慎用。８岁以下儿童不宜服用。

【药物相互作用】
含铝、钙、镁的抗酸药或含铁制剂可影响本药吸收；与巴比妥酸盐、抗惊厥药、柠檬酸氢二钠、碳酸氢钠、乳酸钠、乙酰唑胺、乙氧苯唑胺合用，可降低本药的血浆浓度。

Doryx
Generic name: Doxycycline hyclate

What is Doryx?
Doxycycline is a broad-spectrum tetracycline antibiotic used against a wide variety of bacterial infections, including Rocky Mountain spotted fever and other fevers caused by ticks, fleas, and lice; urinary tract infections; trachoma (chronic infections of the eye); and some gonococcal infections in adults. It is an approved treatment for inhalational anthrax. It is also used with other medications to treat severe acne and amoebic dysentery (diarrhea caused by severe parasitic infection of the intestines).

Doryx may also be taken for the prevention of malaria on foreign trips of less than 4 months' duration.

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What is the most important information I should know about Doryx?
Your doctor will only prescribe Doryx to treat a bacterial infection; it will not cure a viral infection, such as the common cold.

Generally, children under 8 years old and women in the last half of pregnancy should not take this medication. It may cause developing teeth to become permanently discolored. (However, children under 8 may be given this drug for inhalational anthrax.)

As with other antibiotics, treatment with Doryx may result in a growth of bacteria that do not respond to this medication and can cause a secondary infection. An overgrowth of certain bacteria in the colon could cause mild to severe—and rarely, life-threatening—diarrhea. If you develop this symptom, call your doctor immediately.

Bulging foreheads in infants and headaches in adults have occurred. These symptoms disappeared when Doryx was discontinued.

Birth control pills that contain estrogen may not be as effective while you are taking tetracycline drugs. Ask your doctor or pharmacist if you should use another form of birth control while taking Doryx.

Doxycycline syrup (Vibramycin) contains a sulfite that may cause allergic reactions in certain people. This reaction happens more frequently to people with asthma.

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Who should not take Doryx?
If you are sensitive to or have ever had an allergic reaction to Doryx or drugs of this type, you should not take this medication. Make sure your doctor is aware of any drug reactions that you have experienced.

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What should I tell my doctor before I take the first dose of Doryx?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with this drug.

Also, talk to your doctor about your complete medical history.

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What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Adults: The usual dose of oral Doryx is 200 milligrams on the first day of treatment (100 milligrams every 12 hours) followed by a maintenance dose of 100 milligrams per day. The maintenance dose may be taken as a single dose or as 50 milligrams every 12 hours.

Your doctor may prescribe 100 milligrams every 12 hours for severe infections such as chronic urinary tract infection.

Children: For children older than 8 years of age, the recommended dosage schedule for those weighing 100 pounds or less is 2 milligrams per pound of body weight, divided into 2 doses, on the first day of treatment, followed by 1 milligram per pound of body weight given as a single daily dose or divided into 2 doses on subsequent days. For more severe infections, up to 2 milligrams per pound of body weight may be used. For children over 100 pounds, the usual adult dose should be used.

For Uncomplicated Gonorrhea
The usual dose is 100 milligrams by mouth, twice a day for 7 days. An alternate, single-day treatment is 300 milligrams, followed in 1 hour by a second 300-milligram dose.

For Primary and Secondary Syphilis
The usual dose is 200 milligrams a day, divided into smaller, equal doses for 14 days.

For Inhalational Anthrax
Adults: To prevent or combat infection after exposure, the usual dose is 100 milligrams taken by mouth twice a day for 60 days. Treatment can be

started intravenously, but should be switched to oral doses as soon as possible.
Children: For inhalational anthrax in children weighing less than 100 pounds, the usual dose is 1 milligram per pound of body weight twice daily for 60 days.

For Prevention of Malaria
Adults: The usual dose is 100 milligrams a day. Treatment should begin 1 to 2 days before travel to the area where malaria is found, then

continue daily during travel in the area and 4 weeks after leaving.
Children: For prevention of malaria, the recommended dose is 2 milligrams per 2.2 pounds of body weight up to 100 milligrams.

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How should I take Doryx?
Take Doryx with a full glass of water or other liquid to avoid irritating your throat or stomach. Doxycycline can be taken with or without food.

However, if the medicine does upset your stomach, you may wish to take it with a glass of milk or after you have eaten.

Doxycycline tablets should be swallowed whole. If you have difficulty swallowing pills, you can take this medication by opening the capsule and sprinkling the entire contents onto a spoonful of cool, soft applesauce. Be careful not to spill any of the contents. If you do, you will not be able to use this dose and will have to start over with a new mixture. Swallow the mixture immediately, without chewing, followed by a cool 8-ounce glass of water. Discard the mixture if you are not able to use it immediately; do not store it to use later.

If you are taking an oral suspension form of Doryx, shake the bottle well before using. Do not use outdated Doryx.

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What should I avoid while taking Doryx?
You may become more sensitive to sunlight while taking Doryx. Be careful if you are going out in the sun or using a sunlamp. If you develop a skin rash, notify your doctor immediately.

Avoid missing doses. Not completing the full dosage schedule may decrease the drug's effectiveness and increase the chances that the bacteria may become resistant to Doryx and similar antibiotics. It's important to take the full dosage schedule of Doryx, even if you're feeling better in a few days.

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What are possible food and drug interactions associated with Doryx?
If Doryx is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Doryx with the following: antacids containing aluminum, calcium, or magnesium, and iron-containing preparations; barbiturates such as Phenobarbital; bismuth subsalicylate; blood-thinning medications such as warfarin; carbamazepine; oral contraceptives; penicillin; phenytoin; and sodium bicarbonate.

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What are the possible side effects of Doryx?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: angioedema (chest pain; swelling of face, around lips, tongue and throat, arms and legs; difficulty swallowing), bulging foreheads in infants, diarrhea, difficulty swallowing, discolored teeth in infants and children (more common during long-term use of tetracycline), inflammation of the tongue, loss of appetite, nausea, rash, rectal or genital itching, severe allergic reaction (hives, itching, and swelling), skin sensitivity to light, vomiting

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Can I receive Doryx if I am pregnant or breastfeeding?
Doxycycline should not be used during pregnancy. Tetracycline can damage developing teeth during the last half of pregnancy. If you are pregnant or plan to become pregnant, inform your doctor immediately. Tetracyclines such as Doryx appear in breast milk and can affect a nursing infant.

If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

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What should I do if I miss a dose of Doryx?
Take the forgotten dose as soon as you remember. If it is almost time for the next dose, put it off for several hours after taking the missed dose. Specifically, if you are taking one dose a day, take the next one 10 to 12 hours after the missed dose. If you are taking two doses a day, take the next one 5 to 6 hours after the missed dose. If you are taking three doses a day, take the next one 2 to 4 hours after the missed dose.

Then return to your regular schedule.

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How should I store Doryx?
Store at room temperature. Protect from light and excessive heat.

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 详细处方信息以本药内容附件PDF文件（201052622070136.pdf）的“原文Priscribing Information”为准
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