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 详细处方信息以本药内容附件PDF文件（20117319024610.pdf、20117319050436.PDF）的“原文Priscribing Information”为准
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部分中文多巴酚丁胺处方资料（仅供参考）

独步催 注射粉剂 Dobutrex

制造商：美国礼来公司

药理作用：多巴酚丁胺的主要作用是兴奋心脏的β受体，因而增强心肌收缩力。

适应症：在治疗因心肌梗塞/心脏外科手术或各种心肌病变而致心力衰竭的成年病人时，本药可以增强心肌的收缩力。

用法用量：稀释后可静脉输注，一般点滴的速度为2.5-10 ug/kg体重/分，偶有病例低至0.5 ug/kg体重/分的速度即能引起反应。在罕有的情况下，剂量需高至40 ug/kg体重/分。施药的速度及治疗持续时间应按病人的反应来调整，即根据心率、血压、尿量来决定，可能的话，可根据心输出量来决定。应注意勿突然停止用药，应逐渐减量。副作用与剂量的大小有关，当本药以低于10 ug/kg体重/分的输注速度施药时，很少会发生副作用。偶然，高达40 ug/kg体重/分的剂量，亦无显著的不良反应。施药的总液量，视病人对液体的需求而决定。

不良反应：收缩压会增加10-20 mmHg，原有血压高的病者可能会出现血压过高。心率可能增加5-10 次/分。某些病人可发生心动过速或异位心律。对于原有房颤的病者，多巴酚丁胺亦会使心室率增加。暂时停止输注或减少剂量通常能逆转这些情况。甚少的病人曾报告有下列的副作用：恶心，头痛，心绞痛，不明确的胸痛，心悸或呼吸短促。

警告：如果心率或收缩压过分增高，或突然引起心率不整，应减量或暂时停药。当多巴酚丁胺用于急性心肌梗塞时，要进行特别护理，因为心率上出现任何值得注意的减慢都会加重心肌局部缺血，并导致心绞痛及心电图ST段升高。用于患有自发性肥大性主动脉瓣下方狭窄的病者，必须十分小心，因为心收缩力增强剂会导致这些病人的梗塞面积增大。对于明显的机械性梗阻，例如严重主动脉瓣狭窄的病者，本药无改善作用。偶然会出现极轻微的血管收缩作用，多见于最近曾用β-阻滞剂治疗之病者。此乃多巴酚丁胺刺激心脏β1-受体，而增强心肌收缩的这种效能被β-受体阻滞剂阻断所致。

注意事项：对血容量不足的病者，在施用本药前，应先给予全血或血浆以矫正血容量。

孕妇及哺乳期妇女用药：未曾用于孕妇，妊娠期用药之安全性尚有待研究决定。

儿童用药：儿童用药的安全性及功效仍未确定。

药物过量：症状 血压过高或心动过速。

治疗：应把多巴酚丁胺施药的速度减慢或暂时停药，直至病人的情况稳定下来。由于多巴酚丁胺的作用持续时间很短，故所有的不良反应亦为时短暂。

用药须知：可以用注射水或5%葡萄糖配制。加10 mL溶液入瓶内以溶解干粉。新配成的溶液在使用时必须再稀释，将1瓶药物注入250 - 500 mL之下列任一种静注溶液中 ：5%葡萄糖，5%葡萄糖+0.9%氯化钠，5%葡萄糖+0.45%氯化钠，乳酸钠静注溶液。本药不可加入5%碳酸氢钠静注液或其它强碱性的溶液中。勿与其它含有焦亚硫酸钠的制剂或稀释剂合用。含有本药的溶液可能会变为浅红色，且颜色会随时间而加深。此色泽改变是由于药物的轻微氧化所致，但在建议之贮存期间内，对其药效无明显影响。

贮藏/有效期：室温贮藏，重新配制好的溶液可在冰箱内贮存48小时或在室温下贮存6小时。

Dobutamine Hydrochloride Injection
About your treatment.
Your doctor has ordered dobutamine to improve your heart function. The drug will be added to an intravenous fluid that will drip through a needle or catheter placed in your vein over 12 hours, usually every other day.

Dobutamine is used to help your heart pump better by strengthening the heart muscle. Dobutamine also improves blood flow and relieves symptoms of heart failure. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Your health care provider (doctor, nurse, or pharmacist) may measure the effectiveness and side effects of your treatment using laboratory tests and physical examinations. It is important to keep all appointments with your doctor and the laboratory. The length of treatment depends on how you respond to the medication.

Precautions.
Before administering dobutamine,
•tell your doctor and pharmacist if you are allergic to dobutamine or any other drugs.
•tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antidepressants, beta blockers (atenolol, carteolol, esmolol, labetalol, metoprolol, nadolol, propranolol, sotalol, and timolol), bretylium, guanethidine, and vitamins.
•tell your doctor if you have or have ever had heart valve disease or high blood pressure.
•tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking dobutamine, call your doctor immediately.

Administering your medication
Before you administer dobutamine, look at the solution closely. It should be clear and free of floating material. Gently squeeze the bag or observe the solution container to make sure there are no leaks. Do not use the solution if it is discolored, if it contains particles, or if the bag or container leaks. Use a new solution, but show the damaged one to your health care provider.

It is important that you use your medication exactly as directed. Do not stop your therapy on your own for any reason. Do not change your dosing schedule without talking to your health care provider. Your health care provider may tell you to stop your infusion if you have a mechanical problem (such as a blockage in the tubing, needle, or catheter); if you have to stop an infusion, call your health care provider immediately so your therapy can continue.

Side effects
Dobutamine may cause side effects. Tell your health care provider if any of these symptoms are severe or do not go away:
•upset stomach
•vomiting
•tingling sensations
•fever
•leg cramps
•headaches

If you experience any of the following symptoms, call your health care provider immediately:
•irregular heartbeat
•increases in blood pressure and heart rate
•chest pain
•shortness of breath
•swelling of the lower legs and ankles
•increasing fatigue
•lightheadedness, dizziness, or faintness
•skin rash

Storing your medication
•Your health care provider probably will give you several days supply of dobutamine at a time. You may be told to store it in a cool, dry area or in the refrigerator.
•If you refrigerate your dose, take your next dose from the refrigerator 1 hour before using it; place it in a clean, dry area to allow it to warm to room temperature.

Store your medication only as directed. Make sure you understand what you need to store your medication properly.

Keep your supplies in a clean, dry place when you are not using them, and keep all medications and supplies out of reach of children. Your health care provider will tell you how to throw away used needles, syringes, tubing, and containers to avoid accidental injury.

Signs of infection
If you are receiving dobutamine in your vein or under your skin, you need to know the symptoms of a catheter-related infection (an infection where the needle enters your vein or skin). If you experience any of these effects near your intravenous catheter, tell your health care provider as soon as possible:
•tenderness
•warmth
•irritation
•drainage
•redness
•swelling
•pain

Brand names
•Dobutrex® Solution

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 详细处方信息以本药内容附件PDF文件（20117319024610.pdf、20117319050436.PDF）的“原文Priscribing Information”为准
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