---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（20115518430329.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文依普沙坦处方资料（仅供参考）

分类名称
一级分类：循环系统药物 二级分类：抗高血压药物 三级分类：血管紧张素转换酶抑制剂 
 
药品英文名
Eprosartan
 
药品别名
依普沙坦、替维坦、依普罗、Epro、Teveten
 
药理作用
本品为一种新型的非联苯四唑类AT1受体拮抗药，与AT1受体呈竞争性拮抗。作用同氯沙坦相似，通过选择性阻断AngⅡ与AT1受体结合而发挥药理作用。
 
药动学
口服吸收快，进食会延缓其吸收，生物利用度为13%～15%。与血浆蛋白高度结合，结合率达98%。空腹服药约1～2h血药浓度达到高峰，清除半衰期为5～7h。主要经肾脏排泄，占90%。
 
适应证
高血压，尤其是高血压伴肾功能障碍者。
 
禁忌证
无特殊禁忌。
 
注意事项
1.本品在肾功能不全患者中的肾清除率降低。
2.食物对本品吸收的影响有个体差异性。
 
不良反应
发生率低，头痛、头晕与安慰剂相似。
 
用法用量
推荐的安全有效剂量为每次400mg，每天1次。
 
药物相应作用
1.该药与其他药物合用，未见药物间有不良反应发生。
2.不影响地高辛、华法林、双氯噻嗪等药物的药动学。
 
Teveten (eprosartan)
Main use：High blood pressure
Active ingredient：Eprosartan mesylate 
 
How does it work?
Teveten tablets contain the active ingredient eprosartan, which is a type of medicine called an angiotensin II blocker. It works by preventing the action of a hormone in the body called angiotensin II.

Angiotensin II normally acts on special receptors in the body, with two main results. Firstly, it causes the peripheral blood vessels to narrow, and secondly, it stimulates the production of another hormone called aldosterone. Aldosterone causes salt and water to be retained by the kidneys, which increases the volume of fluid in the blood vessels.

Eprosartan blocks the receptors that angiotensin II acts on, and so prevents its actions. The main result of this is that the peripheral blood vessels are allowed to widen, which means that there is more space and less resistance in these blood vessels. This is the main mechanism by which the pressure in the blood vessels is lowered.

Blocking the actions of angiotensin II also reduces the action of aldosterone on the kidneys. The result of this is an increase in the amount of fluid removed from the blood by the kidneys. This decreases the amount of fluid in the blood vessels, which also lessens the resistance and pressure in the blood vessels.

The combined overall effect of these changes is to lower the blood pressure.

What is it used for?
High blood pressure with no known cause (essential hypertension).

Warning!
Teveten tablets should be taken with or after food.
Dizziness and weariness may occasionally occur during treatment with blood pressure lowering medicines. Dizziness can be relieved by lying down until the symptoms pass. If you are affected, caution is required when driving or operating machinery.
People with decreased kidney function should have regular blood tests to monitor the levels of potassium and creatinine in their blood while taking this medicine.

Use with caution in
Elderly people over 75 years
Decreased kidney function
Narrowing of the artery that supplies blood to the kidneys (renal artery stenosis)
Mild to moderately decreased liver function
People with low fluid volume or salt levels in the body, eg due to diuretic therapy, low-sodium diet, diarrhoea or vomiting.

Not to be used in
Severely decreased liver function
Pregnancy
Breastfeeding.
The safety and efficacy of this medicine have not been studied in children. It is not recommended for children.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
This medicine should not be used during pregnancy, as it may be harmful to the developing baby. Seek medical advice from your doctor. If you do fall pregnant you should stop taking this medicine and consult your doctor immediately.
It is not known if this medicine passes into breast milk. It should not be used by women who are breastfeeding. Seek further medical advice from your doctor.

Label warnings
Take this medication with or after food.

Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Dizziness
Pain in the joints (arthralgia)
Inflammation of the lining of the nose (rhinitis) causing a blocked or runny nose
Excess gas in the stomach and intestines (flatulence)
Raised levels of triglycerides in the blood (hypertriglyceridaemia)
High blood potassium level (hyperkalaemia)
Headache
Feeling of weakness
Skin reactions such as rash or itching
Nausea
Severe swelling of lips, face or tongue (angioedema)
Low blood pressure (hypotension)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

If this medicine is taken with other medicines that decrease blood pressure, either as a treatment for high blood pressure or as a side effect, the effects on blood pressure are likely to be additive. If your blood pressure falls too low it might make you feel dizzy, in which case lie down until the feeling passes and let your doctor know, in case your doses need adjusting.

If you are already taking a high dose of a diuretic medicine, eg furosemide, your doctor may need to reduce its dose before you start this medicine, to avoid causing a large drop in blood pressure that might result in dizziness or fainting.

This medicine may increase the blood level of the medicine lithium. If you take this medicine in combination with lithium it is recommended that the level of lithium in your blood is closely monitored.

There may be a risk of raised blood potassium levels (hyperkalaemia) if this medicine is taken with any of the following:
ciclosporin
heparin
potassium-sparing diuretics (eg spironolactone, triamterene, amiloride)
potassium supplements
potassium salts, eg potassium citrate
potassium-containing salt substitutes, eg Lo-salt.

The amount of potassium in your blood should be regularly monitored if you take any of these with this medicine, particularly if you have any problems with your kidneys.

Non-steroidal anti-inflammatory drugs (NSAIDs, eg ibuprofen, diclofenac, indometacin) may reduce the blood pressure lowering effect of eprosartan. They may also increase the risk of raised blood potassium and kidney problems when used in combination with eprosartan. NSAIDs should be used with caution in people taking eprosartan, particularly elderly people, and your doctor may want to monitor your kidney function if you do regularly take an NSAID with this medicine.

Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain eprosartan as the active ingredient.

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（20115518430329.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------