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 详细处方信息以本药内容附件PDF文件（2010101818592522.pdf）的“原文Priscribing Information”为准
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部分中文timentin处方资料（仅供参考）

特美汀 (timentin)
【别名】羧噻吩青霉素钠-棒酸钾;替门汀 、特美汀、替卡西林-克拉维酸钾、羧噻吩青霉素-棒酸钾、替卡西林钠-克拉维酸钾

【外文名】Timentin, Ticarcillin-Potassium Clavulanate、Timentin

【适应症】本品适用于敏感菌所致下呼吸道、骨和关节、皮肤组织、尿路等部位感染以及败血证。由于本品对革兰阳性和阴性需氧及厌氧菌的抗菌范围甚广，故可用于腹腔及产科感染之类混合感染的治疗。 对中枢感染无效。

【用量用法】    
【3.1的用量】注射用药、静推或静滴： 每次注射１瓶，每４～６小时１次，溶于１３ｍｌ等渗盐水或灭菌注射用水中，缓缓静推，或溶于适量溶剂中静滴，３０分钟内滴完。
【3.2g的用量】成人3.2g静注，每６－８hr一次，最大剂量3.2g/4hr, 儿童常用量80mg/kg 体重，静注，每6-8hr一次，早产和足月婴儿刚出生时80 mg/kg体重，静注，每１２hr一次，其后每8hr一次。

【注意事项】
1.本品为青霉素类药物，用前需作青霉素皮试。
2.有过敏反应如皮疹。
3.中枢神经系统功能紊乱、头痛等。
4.胃肠功能紊乱如恶心、腹泻。
5.血小板功能失常、有出血倾向、低钾血症。

【药物相互作用】丙磺舒能减少肾小管对替卡西林的分泌，故可延缓其肾脏排汇，但不影响克拉维酸的肾脏排泄。

【禁忌】青霉素过敏者。

【不良反应】过敏反应：与其它青霉素注射剂相似的副作用。

Timentin
Generic Name: ticarcillin and clavulanate (Intravenous route)
tye-kar-SIL-in dye-SOE-dee-um, KLAV-ue-la-nate poe-TAS-ee-um
Commonly used brand name(s):

In the U.S.
Timentin
Timentin Novaplus

Available Dosage Forms:
Powder for Solution
Solution

Therapeutic Class: Antibiotic
Pharmacologic Class: Ticarcillin

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Uses For Timentin
Ticarcillin and clavulanate combination is used to treat bacterial infections in many different parts of the body.

Ticarcillin and clavulanate combination is an antibiotic that belongs to the group of medicines known as penicillins and beta-lactamase inhibitors. It works by killing the bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

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Before Using Timentin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ticarcillin and clavulanate combination in children. However, safety and efficacy have not been established in infants below 3 months of age.

Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ticarcillin and clavulanate combination in the elderly. However, elderly patients are more likely to have age-related kidney or heart problems, which may require an adjustment in the dose for patients receiving ticarcillin and clavulanate combination.

Breast Feeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Bleeding problems or
Congestive heart failure or
Diarrhea or
Heart disease or
Hypokalemia (low potassium in the blood)—Use with caution. May make these conditions worse.
Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

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Proper Use of ticarcillin and clavulanate
This section provides information on the proper use of a number of products that contain ticarcillin and clavulanate. It may not be specific to Timentin. Please read with care.

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.

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Precautions While Using Timentin
Your doctor will check your progress closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you have itching; hives; hoarseness; shortness of breath; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth after you receive this medicine.

Ticarcillin and clavulanate combination may cause diarrhea, and in some cases it can be severe. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Ticarcillin and clavulanate combination may decrease the effects of some oral contraceptives (birth control pills). To avoid an unwanted pregnancy, it is a good idea to use additional contraceptive measures with your pills (e.g. condoms, a diaphragm, or a contraceptive foam or jelly) while using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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Timentin Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:
Rare
Blood in the urine
frequent urination
lower abdominal cramping
painful urination

Incidence not known
Abdominal or stomach cramps, pain, or tenderness
black, tarry stools
bleeding gums
blistering, peeling, or loosening of the skin
bloating
changes in skin color
chest pain or discomfort
chills
clay-colored stools
convulsions
cough
dark urine
diarrhea
diarrhea, watery and severe, which may also be bloody
dizziness
fast heartbeat
fever
general tiredness and weakness
headache
increased thirst
irritability
itching
joint or muscle pain
loss of appetite
lower back or side pain
muscle twitching
nausea or vomiting
pain, tenderness, or swelling of the foot or leg
pinpoint red spots on the skin
rash
red skin lesions, often with a purple center
red, irritated eyes
restlessness
seizures
shortness of breath
sore throat
sores, ulcers, or white spots on the lips or in the mouth
swelling or inflammation of the mouth
swollen glands
unpleasant breath odor
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight loss
upper right abdominal pain
vomiting of blood
yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
change in taste or bad unusual or unpleasant (after) taste
difficulty with moving
excess air or gas in the stomach or intestines
full feeling
heartburn
muscle aching, cramping, or stiffness
passing gas
swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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 详细处方信息以本药内容附件PDF文件（2010101818592522.pdf）的“原文Priscribing Information”为准
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2011-4-6更新