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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->抗心率失常药物
处方药:处方药
包装规格: 1毫克/10毫升/瓶
计价单位:
   
生产厂家中文参考译名:
法玛西亚-普强
生产厂家英文名:
PHARMACIA AND UPJOHN
该药品相关信息网址1:
http://www.drugs.com/pro/corvert.html
该药品相关信息网址2:
http://www.rxlist.com/corvert-drug.htm
原产地英文商品名:
CORVERT NP 1mg/10ml/vial
原产地英文药品名:
IBUTILIDE FUMARATE
中文参考商品译名:
CORVERT NP 1毫克/10毫升/瓶
中文参考药品译名:
富马酸伊布利特
中文参考化合物名称:
(±) -N-[4-(4-乙基庚基氨基)-1-羟丁基]甲磺酰胺(E)-2-丁烯二酸(2:1)盐
原产地国家批准上市年份:
1995/12/28
英文适应病症1:
Atrial fibrillation
英文适应病症2:
Atrial flutter
临床试验期:
完成
中文适应病症参考翻译1:
快速心房颤动
中文适应病症参考翻译2:
心房扑动
药品信息:

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 详细处方信息以本药内容附件PDF文件(20114718582622.pdf)的“原文Priscribing Information”为准
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部分中文富马酸伊布利特处方资料(仅供参考)

分类名称
一级分类:循环系统药物 二级分类:抗心律失常药物 三级分类:延长动作电位时程药 
 
药品英文名
Ibutilide
 
药品别名 
伊布利特富马酸盐、Ibutilide Fumarate、Corvert
化学名称:(±) -N-[4-(4-乙基庚基氨基)-1-羟丁基]甲磺酰胺(E)-2-丁烯二酸(2:1)盐
 
药物剂型
伊布利特注射剂:1mg/10ml/瓶。
 
药理作用
本品为甲基磺酰胺的衍生物,具有延长复极的作用。对心脏电生理的研究表明:抑制复极时K 外向电流,通过对K 外向电流的抑制,可延长动作电位时间,延长QT间期,延长心肌的有效不应期。促进平台期缓慢内向Na 电流及平台期内向Ca2 电流,延长动作电位时间,延长心肌的有效不应期和QT间期,减慢传导,使折返激动不易形成。整体动物实验结果表明,本品可终止犬动物模型的持续房扑和房颤,延长QT间期,减少犬急性心肌梗死模型室颤和室速的发生率,并降低室颤时除颤阈值。临床研究表明,本品起效快,在10min内快速静滴本品0.03mg/kg时或在8h内缓慢静滴0.1mg/kg时,可使QT间期延长38%~43%。QT间期延长的幅度与伊布利特的血浆浓度成正相关。本品对QRS时间无明显影响。本品对心率、血压及其他血流动力学指标无明显影响。本品无明显负性肌力作用。
 
药动学
本品口服有较强的首关效应,生物利用度低,故采用静滴。静脉应用后,迅速分布于细胞外液。41%的药物与血浆蛋白结合,本品大部分药物在肝脏代谢。代谢产物共8个,除其中一个代谢产物有活性外,其余7个均无活性。本品t1/2为3~6h,主要通过尿液排出体外。
 
适应证
本品用于治疗快速心房颤动、心房扑动。
 
禁忌证
严重心动过缓、哺乳期、严重心衰、低钾血症、低镁血症、妊娠期妇女原有QT间期延长和扭转型室性心动过速发作史患者禁用。
 
注意事项
1.用药前应检查患者血清钾、镁浓度,并开始抗凝治疗。
2.患者应该住院治疗,并进行连续心电监护,至少应监护4h或至QT间期恢复到基线值。
3.肝功能异常患者,使用本品时,其清除率减低,药物作用时间延长。
4.使用本品后至少4h内不得并用其他延长QT间期的药物。
5.儿童用药安全性尚未评价。
6.老年人由于肝肾、心脏功能降低,用药剂量应谨慎,从低剂量开始。
7.本品可用5%葡萄糖或0.9%氯化钠注射液稀释。稀释液可室温放置24h,或2~8℃放置48h。
 
不良反应
本品耐受良好,可引起尖端扭转型室速,持续单形态室速,非持续单形态室速,AV传导阻滞,束支传导阻滞,室性期前收缩,室上性期前收缩,低血压,体位性低血压,心动过缓,窦性心动过缓,结性心律失常,充血性心衰,心动过速,窦性心动过速,室上性心动过速,心室自身节律,高血压,QT间期延长,心悸,晕厥,肾衰。其他不良反应为恶心、头痛。
 
用法用量
静脉给药,推荐剂量:体重>60kg,首剂1mg,10min内静脉滴注,如需要,10min后第二次滴注,剂量仍为1mg;体重<60kg,首剂0.01mg/kg,若需要,再用相同剂量给予第二次治疗。
 
药物相应作用
由于室性心律失常有可能掩盖地高辛过量引起的心脏毒性,血浆地高辛浓度高于或怀疑高于正常水平的患者使用本品应谨慎。β受体阻滞剂和钙拮抗剂对本品无影响。本品与酚噻嗪类、三环类抗抑郁药、四环类抗抑郁药、抗组胺药等能延长QT间期的药物合用,导致心律失常的危险性增加。

Corvert
Pronunciation: eye-BYOO-tih-lide
Generic Name: Ibutilide
Brand Name: Corvert

Corvert is used for:
Treating irregular heart rhythms. It may also be used for other conditions as determined by your doctor.

Corvert is an antiarrhythmic. It works by slowing the conduction of the irregular heartbeat throughout the heart, which allows an opportunity for the regular heart rhythm to take over.

Do NOT use Corvert if:
you are allergic to any ingredient in Corvert
you have prolonged QT interval in electrocardiogram
you are taking itraconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Corvert:
Some medical conditions may interact with Corvert. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have an irregular or slow heartbeat, congestive heart failure, other heart problems, or low levels of magnesium or potassium

Some MEDICINES MAY INTERACT with Corvert. Tell your health care provider if you are taking any other medicines, especially any of the following:
Arsenic, cisapride, itraconazole, ketolides (eg, telithromycin), macrolides (eg, erythromycin), phenothiazines (eg, promethazine), and other medications that prolong the QT interval because they may increase the risk abnormal heart rhythms, including fatal heart rhythms, such as torsades de pointes

This may not be a complete list of all interactions that may occur. Ask your health care provider if Corvert may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Corvert:
Use Corvert as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Corvert is administered as an infusion at the hospital.
If Corvert contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
If you miss a dose of Corvert, contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Corvert.

Important safety information:
Corvert may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Corvert. Using Corvert alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
Corvert is not recommended for use in CHILDREN. Safety and effectiveness have not been confirmed.
PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Corvert during pregnancy. It is unknown if Corvert is excreted in breast milk. Do not breast-feed while taking Corvert.

Possible side effects of Corvert:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; headache; nausea; rapid heartbeat.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or slow heartbeat; heart block; heart failure; shortness of breath; swelling of feet or ankles; worsening of heart rhythm problems.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include abnormal heart rhythms; heart block.

Proper storage of Corvert:
Corvert is usually handled and stored by a health care provider. If you are using Corvert at home, store Corvert as directed by your pharmacist or health care provider.

General information:
If you have any questions about Corvert, please talk with your doctor, pharmacist, or other health care provider.
Corvert is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Corvert. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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 详细处方信息以本药内容附件PDF文件(20114718582622.pdf)的“原文Priscribing Information”为准
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2011-4-8更新

更新日期: 2011-4-8
附件:




20114718582622.pdf    

 
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