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 详细处方信息以本药内容附件PDF文件（201072719191717.pdf）的“原文Priscribing Information”为准
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部分中文Vytorin处方资料（仅供参考）

英文药名: Vytorin(Ezetimibe/Simvastatin Tablets)

中文药名: 依泽替米贝辛伐他汀片

药品简介:
    Vytorin是依泽替米贝和辛伐他汀合剂，属于降胆固醇药物，应用到高胆固醇的个人。 Vytorin是通过减少小肠对胆固醇的吸收从而达到降低胆固醇的作用。
    Vytorin用于具有高胆固醇或原发性高胆固醇血症患者。通常当另一种降胆固醇药物，结合低胆固醇的饮食和运动不足以降低胆固醇时使用Vytorin。
    Vytorin对胆固醇过高和饮食本身不能充分地降低胆固醇病人的作用很好。 Vytorin降低总胆固醇，低密度脂蛋白（坏）胆固醇和甘油三酯，增加高密度脂蛋白（好的）胆固醇。低密度脂蛋白胆固醇是'坏'胆固醇，可以阻塞血管。高密度脂蛋白胆固醇通常被称为'好'胆固醇，因为它有助于防止坏胆固醇堆积在动脉上并且预防心脏病。Vytorin也可以增加血液中的高密度脂蛋白（好）从而减少对小动脉的硬化，减少了心脏病，中风硬化的风险，以及周边血管疾病。
    Vytorin应该根据医生的指导下服用。即使没有立即有所好转，继续按医生的规定服用。对Vytorin的服用剂量不同的病人不同，一般每天一次在睡前服用，与食物同服并饮用一杯水, 或遵医生推荐的口服剂量。 Vytorin由默克公司生产，目前可提供10毫克，20毫克，40毫克和80毫克片剂。
    可能的副作用：过敏性反应，呼吸困难，肿胀的嘴唇，尿液减少或铁锈色的尿，视力模糊，腹胀，恶心，肠胃不适，胃灼热，腹痛，便秘或腹泻，咳嗽，疲劳，头痛，失眠等。

Vytorin
Generic Name: ezetimibe and simvastatin (ez ET i mibe and SIM va stat in)
Brand Names: Vytorin

What is Vytorin?
Vytorin contains a combination ezetimibe and simvastatin. Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins."

Vytorin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Vytorin is used to treat high cholesterol in adults and children who are at least 10 years old.

Vytorin may also be used for other purposes not listed in this medication guide.

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Important information about Vytorin
You should not take Vytorin if you are allergic to ezetimibe or simvastatin, if you are pregnant or breast-feeding, or if you have liver disease. Stop taking Vytorin and tell your doctor right away if you become pregnant.

Before taking Vytorin, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.

In rare cases, Vytorin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Avoid eating foods that are high in fat or cholesterol. Vytorin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

There are many other drugs that can increase your risk of serious medical problems if you take them together with Vytorin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Vytorin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

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Before taking Vytorin
You should not take Vytorin if you are allergic to ezetimibe or simvastatin, if you are pregnant or breast-feeding, or if you have liver disease.

If you have any of these other conditions, your doctor may need to adjust your Vytorin dose or order special tests:
history of liver disease;
history of kidney disease;
diabetes;
a thyroid disorder; or
if you drink more than 2 alcoholic beverages daily.

In rare cases, Vytorin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid). You may also be more likely to develop this condition if you are of Chinese descent and you take high-dose Vytorin while also taking medication that contains niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others).

Tell your doctor about all other medications you use. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them:
amiodarone (Cordarone, Pacerone);
danazol (Danocrine);
nefazodone (an antidepressant);
gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide);
antibiotics such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Extina, Ketozole, Nizoral, Xolegal);
heart or blood pressure medication such as diltiazem (Cartia, Cardizem) or verapamil (Calan, Covera, Isoptin, Verelan);
HIV medications such as atazanavir (Reyataz), ritonavir (Norvir), lopinavir/ritonavir (Kaletra), saquinavir (Invirase), and others;
medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or
drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf).

FDA pregnancy category X. Vytorin can harm an unborn baby or cause birth defects. Do not take Vytorin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking Vytorin. Ezetimibe and simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Vytorin.

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How should I take Vytorin?
Take Vytorin exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Vytorin is usually taken once daily in the evening, with or without food. Your doctor may occasionally change your dose to make sure you get the best results.

You may need to stop using Vytorin for a short time if you have surgery or a medical emergency.

To be sure Vytorin is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

Vytorin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

You may need to take Vytorin on a long-term basis for the treatment of high cholesterol. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

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What should I avoid while taking Vytorin?
If you also take cholestyramine (Prevalite, Questran) or colestipol (Colestid), avoid taking them within 2 hours after or 4 hours before you take Vytorin.

Avoid eating foods that are high in fat or cholesterol. Vytorin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Grapefruit and grapefruit juice may interact with Vytorin and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

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Vytorin side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Vytorin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Vytorin and call your doctor at once if you have any of these serious side effects:
unexplained muscle pain, tenderness, or weakness;
fever, unusual tiredness, and dark colored urine;
swelling, weight gain, urinating less than usual or not at all; or
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious Vytorin side effects may include:
headache, memory problems;
mild muscle pain;
joint pain;
numbness or tingly feeling;
diarrhea;
dizziness, depressed mood;
sleep problems (insomnia); or
cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Vytorin?
Before taking Vytorin, tell your doctor about all other medicines you are using, especially:
digoxin (Lanoxin);
a blood thinner such as warfarin (Coumadin); or
any other "statin" medication such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Altoprev, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor).

This list is not complete and other drugs may interact with Vytorin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about Vytorin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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 详细处方信息以本药内容附件PDF文件（201072719191717.pdf）的“原文Priscribing Information”为准
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