---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201053120245628.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文Duetact 处方资料（仅供参考）
 

英文药名: Duetact (Pioglitazone/Glimepiride Tablets)

中文药名: 吡格列酮格列美脲片

药品介绍
商品名：Duetact；
成分：盐酸吡格列酮和格列美脲；
 
适应症
盐酸吡格列酮+格列美脲复方片剂用于治疗2型糖尿病。吡格列酮可减小胰岛素抵抗，磺酰脲类药物格列美脲可刺激胰腺产生更多的胰岛素，这两种药的作用互相配合可更好的控制2型糖尿病患者。 

Duetact
Generic Name: glimepiride and pioglitazone (glye MEP ir ide and PYE oh GLI ta zone)
Brand Names: Duetact

What is Duetact?
Duetact is a combination of two oral diabetes medicines that help control blood sugar levels.

Duetact is for people with type 2 diabetes who do not use daily insulin injections. It lowers blood sugar by making the cells of the body more sensitive to the action of insulin. Duetact also causes the pancreas to release insulin, which helps to lower blood sugar. This medication is not for treating type 1 diabetes.

Duetact may also be used for other purposes not listed in this medication guide.

---------------------------------------------------------------

Important information about Duetact
You should not use Duetact if you are allergic to glimepiride or pioglitazone, if you have severe heart failure, or if you are in a state of diabetic ketoacidosis.

Before taking Duetact, tell your doctor if you have congestive heart failure or heart disease, a history of heart attack or stroke, liver disease, or kidney disease.

Taking certain oral diabetes medications may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with Duetact.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar.

Before taking Duetact
You should not use Duetact if you are allergic to glimepiride (Amaryl, Avandaryl) or pioglitazone (Actos), or if you have:
severe heart failure; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Duetact:
congestive heart failure or heart disease;
a history of heart attack or stroke; or
liver or kidney disease.

Taking certain oral diabetes medication may increase your risk of serious heart problems. However, not treating your diabetes can damage your heart and other organs. Talk to your doctor about the risks and benefits of treating your diabetes with Duetact.

Some women using Duetact have started having menstrual periods, even after not having a period for a long time due to a medical condition. You may be able to get pregnant if your periods restart. Talk with your doctor about the need for birth control.

FDA pregnancy category C. It is not known whether Duetact is harmful to an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether glimepiride passes into breast milk or if it could harm a nursing baby. Do not use Duetact without telling your doctor if you are breast-feeding a baby.

---------------------------------------------------------------

How should I take Duetact?
Take Duetact exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take Duetact with your first meal of the day.

Duetact is only part of a complete program of treatment that also includes diet, exercise, and weight control. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure Duetact is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested, and you may need regular eye exams. Do not miss any scheduled visits to your doctor.

Your medication needs may change if you become sick or injured, if you have a serious infection, or if you have any type of surgery. Your doctor may want you to stop taking Duetact for a short time if any of these situations affect you.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them:
hunger, headache, confusion, irritability;
drowsiness, weakness, dizziness, tremors;
sweating, fast heartbeat;
seizure (convulsions); or
fainting, coma (severe hypoglycemia can be fatal).

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia. Store Duetact at room temperature, protected from moisture, heat, and light.

---------------------------------------------------------------

What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food). If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

---------------------------------------------------------------

What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. A glimepiride overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

---------------------------------------------------------------

What should I avoid while taking Duetact?
Avoid drinking alcohol while taking Duetact. Alcohol can lower your blood sugar. Avoid exposure to sunlight, sunlamps, or tanning beds. Glimepiride can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

---------------------------------------------------------------

Duetact side effects
Stop using Duetact and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
swelling in your feet, rapid weight gain, feeling short of breath (even with mild exertion);
pale skin, easy bruising or bleeding;
pain or burning when you urinate; or
dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
nausea, vomiting, weakness, loss of appetite, feeling restless or irritable, confusion, hallucinations, muscle pain or weakness, and/or seizure.

Less serious Duetact side effects may include:
sneezing, stuffy nose, cough, sore throat, or other cold symptoms;
gradual weight gain;
mild nausea, diarrhea;
headache, dizziness, blurred vision;
tooth problems; or
mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

---------------------------------------------------------------

What other drugs will affect Duetact?
Before taking Duetact, tell your doctor if you are taking:
delavirdine (Rescriptor);
gemfibrozil (Lopid);
nicardipine (Cardene) or nifedipine (Adalat, Procardia); or
rifampin (Rifadin, Rimactane, Rifater); or
fluconazole (Diflucan), ketoconazole (Nizoral).

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:
albuterol (Proventil, Ventolin);
clonidine (Catapres);
reserpine; or
beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

You may be more likely to have hyperglycemia (high blood sugar) if you are taking Duetact with other drugs that raise blood sugar. Drugs that can raise blood sugar include:
isoniazid;
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking Duetact with other drugs that lower blood sugar. Drugs that can lower blood sugar include:
probenecid (Benemid);
some nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim, Gantanol, Septra, and others); and
a monoamine oxidase inhibitor (MAOI).

This list is not complete and there may be other drugs that can interact with Duetact. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

---------------------------------------------------------------

Where can I get more information?
Your pharmacist can provide more information about Duetact.

Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201053120245628.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------