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详细处方信息以本药内容附件PDF文件（202122418162732.pdf）的“原文Priscribing Information”为准
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部分中文甲硫酸新斯的明处方资料（仅供参考）

Bloxiverz是一种胆碱酯酶抑制剂，通过在胆碱能神经冲动传导部位与乙酰胆碱酯酶竞争性结合而抑制胆碱酯酶的水解。该药物通过促进神经肌肉接头处的冲动传导而提高胆碱能神经活性。新斯的明增高突触乙酰胆碱水平的能力是其有效逆转神经肌肉阻滞效应的基础。新斯的明不易穿透血脑屏障，因此不会对中枢神经系统的胆碱能神经活性产生显著影响。

治疗中最常见的不良反应包括心动过缓、恶心和呕吐。为了降低心动过缓风险，在使用Bloxiverz之前应使用阿托品或格隆溴铵。Bloxiverz应慎用于有心律失常、近期急性冠脉综合征、迷走神经紧张、甲状腺功能亢进、重症肌无力、癫痫或消化性溃疡患者。因为偶有患者发生过敏，故在使用时应备好阿托品和抗过敏药物。当神经肌肉阻滞很轻微时，使用大剂量Bloxiverz可能导致神经肌肉功能障碍。当接近完全从神经肌肉阻滞状况中恢复时，应减少Bloxiverz的剂量。

Efficacy

There is no confirmation that unapproved drugs are effective or deliver the active ingredient/s in their labeled amount and timeframe. Bloxiverz has been reviewed and approved by the FDA so that you can be assured that the product will perform as intended.

INDICATIONS AND USAGE

BLOXIVERZ, a cholinesterase inhibitor, is indicated for the reversal of the effects of non-depolarizing neuromuscular blocking agents (NMBAs) after surgery in adults and pediatric patients of all ages.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

BLOXIVERZ is contraindicated in patients with known hypersensitivity to neostigmine. It is also contraindicated in patients with peritonitis or mechanical obstruction of the intestinal or urinary tract.

WARNINGS AND PRECAUTIONS

Atropine or glycopyrrolate should be administered prior to BLOXIVERZ to minimize risk of bradycardia.

BLOXIVERZ should be used with caution in patients with the following coexisting conditions as serious reactions may occur: coronary artery disease, cardiac arrhythmias, recent acute coronary syndrome or myasthenia gravis.

Neuromuscular dysfunction can occur if large doses of BLOXIVERZ are administered when neuromuscular blockade is minimal; reduce dose if recovery from neuromuscular blockade is nearly complete.

ADVERSE REACTIONS

The most common adverse reactions during treatment are bradycardia, nausea and vomiting.

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详细处方信息以本药内容附件PDF文件（202122418162732.pdf）的“原文Priscribing Information”为准
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