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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->抗抑郁药
处方药:处方药
包装规格: 25毫克 100片/瓶
计价单位:
  点击放大  
生产厂家英文名:
Sandoz Inc
该药品相关信息网址1:
https://www.webmd.com/drugs/2/drug-8611/amitriptyline-oral/details
原产地英文商品名:
Amitriptyline HCl Tablets 25mg 100Tablets/bottle (Minimum order: 10)
原产地英文药品名:
Amitriptyline Hydrochloride
中文参考商品译名:
阿米替林盐酸盐片剂 25毫克 100片/瓶 (最低购买量:10)
中文参考药品译名:
阿米替林盐酸盐
原产地国家批准上市年份:
1977/12/21
英文适应病症1:
relief of symptoms of depression
临床试验期:
完成
中文适应病症参考翻译1:
缓解抑郁症
药品信息:

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详细处方信息以本药内容附件PDF文件(201931315565940.pdf)的“原文Priscribing Information”为准
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部分中文阿米替林盐酸盐片剂处方资料(仅供参考)


【英文名称】
Amitriptyline HCl

【适用证】

缓解抑郁症的症状。 与其他抑郁状态相比,内源性抑郁症更容易缓解。

【用法用量】

口服剂量

剂量应从较低水平开始并逐渐增加,并仔细注意临床反应和任何不耐受的证据。

成人的初始剂量

对于门诊患者,每天75 mg阿米替林盐酸盐的分剂量通常是令人满意的。如有必要,可将其增加至每天150毫克。优选地在下午晚些时候和/或就寝时间剂量增加。在注意到抗抑郁作用之前,镇静作用可能是明显的,但是足够的治疗效果可能需要长达30天才能发展。

在门诊患者中开始治疗的另一种方法是在睡前服用50至100毫克阿米替林盐酸盐。在就寝时间剂量中,这可以增加25或50mg,每天总共150mg。

住院患者最初可能每天需要100毫克。如果需要,这可以逐渐增加到每天200毫克。少数住院患者每天可能需要多达300毫克

青少年和老年患者

一般来说,建议这些患者使用较低的剂量。在不能耐受更高剂量的青少年和老年患者中,每天3次,每次3次,睡前服用20mg可能是令人满意的。

维护

阿米替林盐酸盐的常用维持剂量为每天50至100毫克。在一些患者中,每天40毫克就足够了。对于维持治疗,总日剂量可以单剂量给予,优选在就寝时间给予。当达到令人满意的改善时,应将剂量减少至维持症状缓解的最低量。适当的是继续维持治疗3个月或更长时间以减少复发的可能性。

儿科患者的用法

鉴于在儿科患者中缺乏使用该药物的经验,目前不建议12岁以下的患者使用该药物。

【注意事项】

阿米替林盐酸盐禁用于先前对其过敏的患者。

不应与单胺氧化酶抑制剂同时给予。 同时接受三环类抗抑郁药和单胺氧化酶抑制药物的患者出现了高热病危象,严重抽搐和死亡。 当需要替换单胺氧化酶抑制剂时 使用盐酸阿米替林后,停用前至少14天。 然后应小心开始使用阿米替林盐酸盐,逐渐增加剂量,直至达到最佳反应。

阿米替林盐酸盐不应与西沙必利一起使用,因为QT间期可能增加,心律失常风险增加。

不建议在心肌梗塞后的急性恢复期使用该药。

【INDICATIONS AND USAGE】

For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.

【CONTRAINDICATIONS】

Amitriptyline hydrochloride is contraindicated in patients who have shown prior hypersensitivity to it.

It should not be given concomitantly with monoamine oxidase inhibitors. Hyperpyretic crises, severe convulsions, and deaths have occurred in patients receiving tricyclic antidepressant and monoamine oxidase inhibiting drugs simultaneously. When it is desired to replace a monoamine oxidase inhibitor with amitriptyline hydrochloride, a minimum of 14 days should be allowed to elapse after the former is discontinued. Amitriptyline hydrochloride should then be initiated cautiously with gradual increase in dosage until optimum response is achieved.

Amitriptyline hydrochloride should not be given with cisapride due to the potential for increased QT interval and increased risk for arrhythmia.

This drug is not recommended for use during the acute recovery phase following myocardial infarction.

【DOSAGE AND ADMINISTRATION】

Oral Dosage

Dosage should be initiated at a low level and increased gradually, noting carefully the clinical response and any evidence of intolerance.

Initial Dosage for Adults

For outpatients, 75 mg of amitriptyline HCl a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day. Increases are made preferably in the late afternoon and/or bedtime doses. A sedative effect may be apparent before the antidepressant effect is noted, but an adequate therapeutic effect may take as long as 30 days to develop.

An alternate method of initiating therapy in outpatients is to begin with 50 to 100 mg amitriptyline HCl at bedtime. This may be increased by 25 or 50 mg as necessary in the bedtime dose to a total of 150 mg per day.

Hospitalized patients may require 100 mg a day initially. This can be increased gradually to 200 mg a day if necessary. A small number of hospitalized patients may need as much as 300 mg a day

Adoles cent and Elderly Patients

In general, lower dosages are recommended for these patients. Ten mg 3 times a day with 20 mg at bedtime may be satisfactory in adolescent and elderly patients who do not tolerate higher dosages.

Maintenance

The usual maintenance dosage of amitriptyline HCl is 50 to 100 mg per day. In some patients, 40 mg per day is sufficient. For maintenance therapy, the total daily dosage may be given in a single dose, preferably at bedtime. When satisfactory improvement has been reached, dosage should be reduced to the lowest amount that will maintain relief of symptoms. It is appropriate to continue maintenance therapy 3 months or longer to lessen the possibility of relapse.

Usage in Pediatric Patients

In view of the lack of experience with the use of this drug in pediatric patients, it is not recommended at the present time for patients under 12 years of age.

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详细处方信息以本药内容附件PDF文件(201931315565940.pdf)的“原文Priscribing Information”为准
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更新日期: 2019-3-12
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