您好,欢迎光临世界标品! 登录 注册(订药物标准品请用邮件联系我们)

中国医药研发对照标品提供商
Non-clinical Research-used
Medicine Sample Provider

当前本网站药物产品种数共 8063 处方药 7688 非处方药 259 保健品/医疗用具 116

世界标品医药目录搜索(中英文):
世界各国官方药品目录搜索(英文):
世界标品医药知识搜索(中英文):

联系方式
国际免费电话:
QQ客服1:1793093587
QQ客服2:1586083059
QQ客服3:2786706041
QQ客服6:2992753224
QQ客服7:2394834588

咨询邮箱:
scimed.shanghai@shijiebiaopin.com
info@shijiebiaopin.com
pharmacy.shijiebiaopin1@gmail.com
pharmacy.shijiebiaopin2@gmail.com

  药店国别: 澳大利亚药房
产地国家: 德国
所属类别: 抗微生物药物->其他抗生素
处方药:处方药
包装规格: 400毫克/片 250毫升/包
计价单位:
  点击放大  
生产厂家中文参考译名:
拜耳
生产厂家英文名:
BAYER
该药品相关信息网址1:
http://www.avelox.com/
该药品相关信息网址2:
http://www.drugs.com/avelox.html
该药品相关信息网址3:
http://www.rxlist.com/avelox-drug.htm
原产地英文商品名:
Avelox 400mg Soln 250ml/Bag (Minimum order qty:5)
原产地英文药品名:
MOXIFLOXACIN HCL
中文参考商品译名:
拜复乐溶液 400毫克 250毫升/包 (最低购买量:5)
中文参考药品译名:
盐酸莫西沙星
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Acute sinusitis
英文适应病症2:
Acute exacerbation of chronic bronchitis
英文适应病症3:
Community-acquired pneumonia
英文适应病症4:
Skin and soft tissue infections
临床试验期:
完成
中文适应病症参考翻译1:
急性窦炎
中文适应病症参考翻译2:
慢性支气管炎急性发作
中文适应病症参考翻译3:
社区获得性肺炎
中文适应病症参考翻译4:
皮肤和软组织感染
药品信息:

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(20191623012940.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文AVELOX处方资料(仅供参考)

    先灵葆雅公司宣布美国FDA已批准该公司的每日仅需用药一次的抗生素AVELOX(盐酸莫西沙星)用于治疗由对甲氧西林敏感的金黄色葡萄球菌埃希氏大肠杆菌克雷白肺炎杆菌或阴沟肠杆菌等引起的成人复杂性皮肤及皮肤组织感染(cSSSI)AVELOX由拜耳公司开发其在美国的销售由先灵葆雅公司负责。
  据悉美国每年发生250万例cSSSI其中约40万人需住院治疗[1]以往cSSSI治疗通常有赖于大剂量抗生素且每日需多次给药。
  位于加州圣莫尼卡的R.M. Alden科研实验室主任兼UCLA David Geffen药学院教授Ellie J.C. Goldstein博士认为:“复杂性皮肤及皮肤组织感染可发展到十分严重的程度并需外科手术治疗而每日仅需给药一次的AVELOX为患者提供了方便有效的治疗选择”。
  先灵葆雅学院医学总监兼分管医疗事务的副总裁Robert J. Spiegel博士认为:“FDA对AVELOX新适应症的批准意味着患者将能获得有益的治疗选择而这对于充实先灵葆雅公司已有的感染类药物系列而言也具有重大意义”。
  先灵葆雅公司于2004年10月获得了拜耳公司开发的氟喹诺酮类抗生素AVELOX和CIPRO(环丙沙星)在美国的独家销售代理权作为新药应用申请批文(ND)及AVELOX专利权的持有者拜耳公司完成了与新药相关的研发工作并向FDA提出申报。
  促成FDA批准的临床试验的结果表明每日一次(QD)静脉滴注(IV)或口服(PO)AVELOX用于治疗cSSSI的效果与对照方案(每日静脉应用哌拉西林/他唑巴坦后改用每日2次口服阿莫西林/克拉维酸)的效果相当。
  此次FDA批准AVELOX治疗cSSSI是该药第5个适应症其余4个适应症分别为急性细菌性鼻窦炎慢性支气管炎急性细菌感染性恶化社区获得性肺炎和单纯性皮肤及皮肤组织感染。

AVELOX用于cSSSI治疗的相关研究
  迄今已有2项针对cSSSI的随机对照研究其中1项在北美开展的双盲前瞻性多中心试验对AVELO(400mgIV/POQD7-14d)与β-内酰胺类/β-内酰胺酶抑制剂用于治疗cSSSI的效果进行了对比研究共纳入617位患者其中335位的资料符合有效性分析标准试验对象所患感染包括脓肿蜂窝织炎褥疮外科伤口感染创伤等另一跨国研究比较了AVELOX(400mgQD7-21d)与β-内酰胺类/β-内酰胺酶抑制剂(IV/PO)用于治疗cSSSI的效果研究纳入了804位患者其中632位的资料符合有效性分析标准。
  在北美试验中AVELOX与对照药物的有效性分别位77.2%和81.5%;两者对甲氧西林敏感的金黄色葡萄球菌的清除率相当分别为82.2%和87.6%而甲氧西林敏感的金黄色葡萄球菌正是导致cSSSI的主要病原体对2项试验数据进行汇总分析后发现AVELOX及对照药物的临床治疗成功率分别为81.6%和84.8%(大肠杆菌)91.7%和70%(肺炎克雷白菌)及81.8%和57.1%(阴沟肠杆菌)

有关cSSSI
  众多皮肤及皮肤组织感染(如浅部皮肤感染蜂窝织炎及单纯性脓肿)的病原体谱较为相似一旦皮肤感染累及深部软组织(肌肉脂肪等)即被称为cSSSI并可能需要外科干预(如感染性溃疡烧伤大型脓肿等);如伴有其他基础性疾病则对常规治疗的反应较差可引发cSSSI的细菌种类众多并与患者临床状况损伤或感染部位及既往病史有关。

关于AVELOX
  AVELOX获准治疗以下疾病:由肺炎链球菌流感嗜血杆菌副流感嗜血杆菌肺炎克雷白菌金黄色葡萄球菌或卡他莫拉菌导致的慢性支气管炎急性细菌感染性恶化(ABECB);肺炎链球菌流感嗜血杆菌或卡他莫拉菌导致的急性细菌性鼻窦炎(ABS);肺炎链球菌(包括多药耐受菌株*)流感嗜血杆菌卡他莫拉菌金黄色葡萄球菌肺炎克雷白菌肺炎支原体或肺炎衣原体导致的社区获得性肺炎(CAP);金黄色葡萄球菌及化脓性链球菌导致的uSSSI;由对甲氧西林敏感的金黄色葡萄球菌埃希氏大肠杆菌克雷白肺炎杆菌或阴沟肠杆菌等引起的cSSSI。
  *多药耐受性肺炎链球菌包括耐青霉素肺炎链球菌株(PRSP)以及至少对以下抗生素中的2中耐药的菌株:青霉素(MIC≥2ug/ml)第二代头孢菌素(如头孢呋辛)大环内酯类四环素类及甲氧苄氨嘧啶-磺胺甲基异恶唑等。

AVELOX的安全性信息
  机体对AVELOX通常具有良好的耐受性其不良反应发生率与其他标准治疗相差无几AVELOX最常见的副作用就是头晕恶心和腹泻但通常都较为轻微在明确AVELOX是否会导致个体产生头晕之前建议在用药后谨慎驾驶或操作机械设备一旦出现药物不良反应患者应及时告知医生。
  曾对AVELOX过敏或对其他喹诺酮类药物(如环丙沙星和左氧氟沙星)过敏者不应使用AVELOX。
  患有心律失常及正在使用抗心律失常药物(奎尼定普鲁卡因可达龙和心得宜等)的患者应避免使用AVELOX。
  由于AVELOX对胎儿或接受母乳喂养的幼儿的影响目前尚未明确故该药不应用于妊娠期或哺乳期女性AVELOX不适用于18岁以下儿童。
  曾有接受喹诺酮类药物治疗的患者出现抽搐的报道如果之前就由癫痫史应事先告知医生
  抗酸剂和复合维生素制剂可能干扰AVELOX的吸收从而影响其有效性患者应在服用上述药物之前4小时或之后8小时服用AVELOX。
 
适应症
    患有上呼吸道和下呼吸道感染的成人(≥18岁),如急性窦炎、慢性支气管炎急性发作、社区获得性肺炎,以及皮肤和软组织感染。

用法用量
   

Avelox将始终由医生或医疗保健专业人员提供给您。

成人的推荐剂量是每天一次一瓶。

Avelox用于静脉注射。您的医生应确保在60分钟内以恒定流量输注。

老年患者,体重低的患者或肾脏问题患者不需要调整剂量。

您的医生将决定您使用Avelox治疗的持续时间。在某些情况下,您的医生可能会开始使用Avelox溶液进行输液治疗,然后继续使用Avelox药片进行治疗。

治疗的持续时间取决于感染的类型,以及您对治疗的反应程度,但建议的使用持续时间为:

在医院外获得的肺部感染(肺炎)7-14天

大多数肺炎患者在4天内改用Avelox片剂口服治疗。

皮肤和软组织感染7-21天,对于具有复杂皮肤和皮肤结构感染的患者,静脉内治疗的平均持续时间约为6天,并且治疗的平均总持续时间(输注随后是片剂)为13天。

完成治疗过程非常重要,即使您在几天后感觉好转也是如此。如果您过早停止使用该药,您的感染可能无法完全治愈,感染可能会恢复或您的病情可能会恶化,您也可能对抗生素产生细菌耐药性。

不应超过推荐剂量和治疗持续时间(参见第2节。在您使用Avelox之前需要了解的内容,警告和注意事项)。
 
Avelox
Generic Name: moxifloxacin (moxi FLOX a sin)
Brand Names: Avelox

----------------------------------------------------------

What is Avelox?
Avelox is an antibiotic in the class of drugs called fluoroquinolones. It fights bacteria in the body. It kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Avelox is used to treat bacterial infections caused by certain bacteria.

Avelox may also be used for other purposes not listed in this medication guide.

----------------------------------------------------------

Important information about Avelox
You should not use Avelox if you are allergic to moxifloxacin or similar antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin), ofloxacin (Floxin), norfloxacin (Noroxin), lomefloxacin (Maxaquin), and others.

Before taking Avelox, tell your doctor if you have kidney or liver disease, myasthenia gravis, joint problems, diabetes, a history of seizures, low levels of potassium in your blood (hypokalemia), or a personal or family history of "Long QT syndrome."

Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 8 hours before or 4 hours after you take Avelox. These other medicines can make Avelox much less effective when taken at the same time.

Taking Avelox can make your skin more sensitive to sunlight. Avoid exposure to sunlight, sun lamps, or tanning beds.

Avelox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take an oral steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Avelox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Avelox with another person (especially a child), even if they have the same symptoms you do.

----------------------------------------------------------

Before taking Avelox
Do not use Avelox if you are allergic to moxifloxacin or similar medications such as ciprofloxacin (Cipro), levofloxacin (Levaquin), ofloxacin (Floxin), norfloxacin (Noroxin), lomefloxacin (Maxaquin), and others.

Before taking Avelox, tell your doctor if you have a heart rhythm disorder, especially if you are being treated with one of these medications: quinidine (Cardioquin, Quinidex, Quinaglute), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take Avelox, tell your doctor if you have:
a history of allergic reaction to an antibiotic;
myasthenia gravis;
joint problems;
kidney or liver disease, cirrhosis;
epilepsy or a history of seizures;
diabetes;
low levels of potassium in your blood (hypokalemia); or
a personal or family history of "Long QT syndrome."

FDA pregnancy category C: It is not known whether Avelox is harmful to an unborn baby. Do not use Avelox without telling your doctor if you are pregnant. Tell your doctor if you become pregnant during treatment. Moxifloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Avelox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take an oral steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Avelox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Avelox with another person (especially a child), even if they have the same symptoms you do.

----------------------------------------------------------

How should I take Avelox?
Take Avelox will always be given to you by a doctor or healthcare professional. The recommended dose for adults is one bottle once daily. Avelox is for intravenous use. Your doctor should ensure that the infusion is given at a constant flow over 60 minutes. No adjustment of the dose is required in elderly patients, patients with a low bodyweight or in patients with kidney problems. Your doctor will decide on the duration of your treatment with Avelox. In some cases your doctor may start your treatment with Avelox solution for infusion and then continue your treatment with Avelox tablets. The duration of treatment depends upon the type of infection, and how well you respond to treatment but the recommended durations of use are: Infection of the lungs (pneumonia) acquired outside the hospital 7 - 14 days Most patients with pneumonia were switched to oral treatment with Avelox tablets within 4 days. Infections of the skin and soft tissue 7 - 21 days For patients with complicated skin and skin structure infections the mean duration of intravenous treatment was approximately 6 days and the average overall duration of treatment (infusion followed by tablets) was 13 days. It is important that you complete the course of treatment, even if you begin to feel better after a few days. If you stop using this medicine too soon your infection may not be completely cured, the infection may return or your condition may get worse, and you may also create a bacterial resistance to the antibiotic. The recommended dose and duration of treatment should not be exceeded (see section 2. What you need to know before you are administered Avelox, Warnings and precautions).

----------------------------------------------------------

What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

----------------------------------------------------------

What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include tremors, nausea, vomiting, diarrhea, and seizures (convulsions).

----------------------------------------------------------

What should I avoid while taking Avelox?
You may be taking certain other medicines that should not be taken at the same time as Avelox. Avoid taking the following medicines within 8 hours before or 4 hours after you take Avelox. These other medicines can make Avelox much less effective when taken at the same time:
antacids that contain magnesium or aluminum (such as Maalox, Mylanta, or Rolaids);
the ulcer medicine sucralfate (Carafate);
didanosine (Videx) powder or chewable tablets; or
vitamin or mineral supplements that contain iron or zinc.

Avoid exposure to sunlight, sunlamps, or tanning beds. Avelox can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use a sunscreen (SPF-15 or higher) if you must be out in the sun. Call your doctor if you have severe burning, redness, itching, rash, or swelling after being in the sun.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Avelox can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

----------------------------------------------------------

Avelox side effects
Stop using Avelox and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Avelox and call your doctor at once if you have any of these serious side effects:
dizziness, fainting, fast or pounding heartbeat;
sudden pain or swelling near your joints (especially in your arm or ankle);
diarrhea that is watery or bloody;
confusion, hallucinations, depression, unusual thoughts or behavior;
seizure (convulsions);
pale or yellowed skin, dark colored urine, fever, weakness;
urinating less than usual or not at all;
easy bruising or bleeding;
numbness, tingling, or unusual pain anywhere in your body;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
the first sign of any skin rash, no matter how mild.

Less serious Avelox side effects may include:
nausea, vomiting;
drowsiness;
blurred vision;
feeling nervous, anxious, or agitated;
sleep problems (insomnia or nightmares); or
mild skin itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

----------------------------------------------------------

What other drugs will affect Avelox?
Before taking Avelox, tell your doctor if you are taking any of the following drugs:
insulin or diabetes medication you take by mouth, such as glyburide (Micronase, Diabeta, Glynase);
a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), etodolac (Lodine), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), nabumetone (Relafen), meloxicam (Mobic), naproxen (Aleve, Naprosyn, Anaprox), piroxicam (Feldene), and others; or
an oral steroid medication such as betamethasone (Celestone), dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), prednisolone (Orapred), prednisone (Meticorten, Sterapred), and others.

This list is not complete and there may be other drugs that can interact with Avelox. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

----------------------------------------------------------

Where can I get more information?
Your pharmacist can provide more information about Avelox.

Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(20191623012940.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

2019年1月6日更新

更新日期: 2019-1-6
附件:
20191623012940.pdf    

 
调控比例: 100%
订购表单下载
Copyrights © 2010,2011,2012 www.ShiJieBiaoPin.com, Inc., All rights Reserved www.ShiJieBiaoPin.com, Inc.
客服工作时间:太平洋时间18:00-24:00
国际免费电话:
友情提示:以上电话为免费电话,无需您承担任何费用,世界标品提供中文客服,请您放心拨打!
电子邮箱:info.shijiebiaopin.com@gmail.com, info@shijiebiaopin.com