---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201892022195911.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------
部分維生素C注射处方资料（仅供参考）

说明

抗坏血酸（维生素C）是一种水溶性维生素。它以白色或微黄色晶体或具有轻微酸味的粉末形式存在。它是一种抗坏血酸产品。在曝光时，它会逐渐变暗。在干燥状态下，它在空气中相当稳定，但在溶液中它会迅速氧化。抗坏血酸（维生素c）易溶于水;微溶于酒精;不溶于氯仿，乙醚和苯。抗坏血酸（维生素c）的化学名称是L-抗坏血酸（维生素c）。经验式为C6H806，分子量为176.13。

抗坏血酸（维生素c）注射液是一种无菌溶液。每mL含有：250毫克抗坏血酸（维生素c）和注射用水中的乙二胺四乙酸二钠0.025％。在碳酸氢钠的帮助下制备。可以使用氢氧化钠和/或盐酸来调节pH。

适应症

维生素C被推荐用于预防和治疗坏血病。对于急性缺乏症患者或口服摄入抗坏血酸（维生素c）的吸收不确定的患者，其肠胃外给药是理想的。

轻度缺乏的症状可能包括骨骼和牙齿发育不良，牙龈炎，牙龈出血和牙齿松动。发热状态，慢性疾病和感染（肺炎，百日咳，肺结核，白喉，鼻窦炎，风湿热等）增加了对抗坏血酸（维生素c）的需求。

血管疾病，烧伤，骨折延迟和伤口愈合是每日摄入量增加的迹象。

剂量和用量

抗坏血酸（维生素c）通常口服给药。当口服给药不可行或怀疑吸收不良时，可以IM，IV或皮下给药。当肠胃外给药时，据报道，IM给药后维生素的利用最好，这是优选的肠胃外途径。

对于静脉注射，建议稀释成大量肠外注射，如生理盐水，注射用水或葡萄糖，以尽量减少与静脉注射相关的不良反应。

成人维生素C的平均保护剂量为每日70至150毫克。在坏血病的情况下，建议每日剂量为300毫克至1克。然而，对于没有毒性证据的正常成人肠胃外给予多达6克。

为了增强伤口愈合，通常认为术前和术后每天300至500毫克，一周或十天的剂量是足够的，尽管建议使用相当大的剂量。在烧伤的治疗中，剂量受组织损伤程度的控制。对于严重烧伤，建议每日剂量为1至2克。在其他需要维生素C增加的情况下，每日最佳配量的三到五倍似乎就足够了。

当溶液和容器允许时，应在给药前目视检查肠外药物产品中的颗粒物和变色。

副作用

在肌肉注射或皮下注射部位可能发生短暂的轻微酸痛。过快地静脉注射溶液可能会导致暂时的晕眩或头晕。

药物相互作用

有限的证据表明，抗坏血酸（维生素c）可能影响双羟基香豆素的作用强度和持续时间。

警告

糖尿病患者，易患复发性肾结石的患者，接受大便潜血试验的患者，以及限钠饮食或抗凝治疗的患者，不应长期服用过量的维生素C.

注意事项

一般注意事项

应避免过快的静脉注射。

实验室测试

每天服用超过500毫克维生素C的糖尿病患者可能会获得尿糖测试的错误读数。在进行胺依赖性粪便隐血试验之前，不应摄入外源性维生素C 48至72小时，因为可能会出现假阴性结果。

妊娠期使用

怀孕类别C.'尚未用抗坏血酸（维生素c）注射剂进行动物繁殖研究。还不知道抗坏血酸（维生素c）注射剂在给孕妇服用时是否会引起胎儿伤害，或者是否会影响生殖能力。只有在明确需要时才应给孕妇注射抗坏血酸（维生素c）。

护理母亲

当给予哺乳期妇女抗坏血酸（维生素c）注射剂时，应谨慎行事。

OVERDOSE

未提供任何信息。

禁忌

对那些对该制剂的任何成分过敏的人禁用。

DESCRIPTION

Ascorbic acid (vitamin C) is a water-soluble vitamin. It occurs as a white or slightly yellow crystal or powder with a slight acidic taste. It is an antiscorbutic product. On exposure to light, it gradually darkens. In the dry state, it is reasonably stable in air, but in solution it rapidly oxidizes. Ascorbic acid (vitamin c) is freely soluble in water; sparingly soluble in alcohol; insoluble in chloroform, in ether, and in benzene. The chemical name of ascorbic acid (vitamin c) is L-ascorbic acid (vitamin c) . The empirical formula is C6H806, and the molecular weight is 176.13.

Ascorbic Acid (vitamin c) Injection is a sterile solution. Each mL contains: Ascorbic Acid (vitamin c) 250 mg and Edetate Disodium 0.025% in Water for Injection qs. Prepared with the aid of Sodium Bicarbonate. Sodium Hydroxide and/or Hydrochloric Acid may have been used to adjust pH.

INDICATIONS

Vitamin C is recommended for the prevention and treatment of scurvy. Its parenteral administration is desirable for patients with an acute deficiency or for those whose absorption of orally ingested ascorbic acid (vitamin c) is uncertain.

Symptoms of mild deficiency may include faulty bone and tooth development, gingivitis, bleeding gums, and loosened teeth. Febrile states, chronic illness, and infection (pneumonia, whooping cough, tuberculosis, diphtheria, sinusitis, rheumatic fever, etc.) increase the need for ascorbic acid (vitamin c) .

Hemovascular disorders, burns, delayed fracture and wound healing are indications for an increase in the daily intake.

DOSAGE AND ADMINISTRATION

Ascorbic acid (vitamin c) is usually administered orally. When oral administration is not feasible or when malabsorption is suspected, the drug may be administered IM, IV, or subcutaneously. When given parenterally, utilization of the vitamin reportedly is best after IM administration and that is the preferred parenteral route.

For intravenous injection, dilution into a large volume parenteral such as Normal Saline, Water for Injection, or Glucose is recommended to minimize the adverse reactions associated with intravenous injection.

The average protective dose of vitamin C for adults is 70 to 150 mg daily. In the presence of scurvy, doses of 300 mg to 1 g daily are recommended. However, as much as 6 g has been administered parenterally to normal adults without evidence of toxicity.

To enhance wound healing, doses of 300 to 500 mg daily for a week or ten days both preoperatively and postoperatively are generally considered adequate, although considerably larger amounts have been recommended. In the treatment of burns, doses are governed by the extent of tissue injury. For severe burns, daily doses of 1 to 2 g are recommended. In other conditions in which the need for vitamin C is increased, three to five times the daily optimum allowances appear to be adequate.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.

SIDE EFFECTS

Transient mild soreness may occur at the site of intramuscular or subcutaneous injection. Too-rapid intravenous administration of the solution may cause temporary faintness or dizziness.

DRUG INTERACTIONS

Limited evidence suggests that ascorbic acid (vitamin c) may influence the intensity and duration of action of bishydroxycoumarin.

WARNINGS

Diabetics, patients prone to recurrent renal calculi, those undergoing stool occult blood tests, and those on sodium-restricted diets or anticoagulant therapy should not take excessive doses of vitamin C over an extended period of time.

PRECAUTIONS

General Precautions

Too-rapid intravenous injection is to be avoided.

Laboratory Tests

Diabetics taking more than 500 mg vitamin C daily may obtain false readings of their urinary glucose test. No exogenous vitamin C should be ingested for 48 to 72 hours before amine-dependent stool occult blood tests are conducted because possible false-negative results may occur.

Usage in Pregnancy

Pregnancy Category C.' Animal reproduction studies have not been conducted with Ascorbic Acid (vitamin c) Injection. It is also not known whether Ascorbic Acid (vitamin c) Injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Ascorbic Acid (vitamin c) Injection should be given to a pregnant woman only if clearly needed.

Nursing Mothers

Caution should be exercised when Ascorbic Acid (vitamin c) Injection is administered to a nursing woman.

OVERDOSE

No information provided.

CONTRAINDICATIONS

Contraindicated in those persons who have shown hypersensitivity to any component of this preparation.

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201892022195911.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------