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  药店国别: 美国药房
产地国家: 美国
所属类别: 皮肤科药物->皮肤炎症
处方药:处方药
包装规格: 45克/管
计价单位:
  点击放大  
生产厂家中文参考译名:
Mylan Lab USA
生产厂家英文名:
Mylan Lab USA
该药品相关信息网址1:
http://www.rxlist.com/zonalon-drug.htm
该药品相关信息网址2:
http://www.drugs.com/cdi/zonalon-cream.html
原产地英文商品名:
ZONALON 5% CREAM 45g/tube
原产地英文药品名:
DOXEPIN HYDROCHLORIDE
中文参考商品译名:
ZONALON 5%软膏 45克/管
中文参考药品译名:
盐酸多塞平
原产地国家批准上市年份:
1994/04/01
英文适应病症1:
Eczema Dermatitis
英文适应病症2:
Itching
英文适应病症3:
atopic dermatitis
英文适应病症4:
lichen simplex chronicus
临床试验期:
完成
中文适应病症参考翻译1:
湿疹性皮肤炎
中文适应病症参考翻译2:
搔痒
中文适应病症参考翻译3:
异位性皮肤炎
中文适应病症参考翻译4:
单纯性慢性苔藓
药品信息:

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 详细处方信息以本药内容附件PDF文件(201882622072813.pdf)的“原文Priscribing Information”为准
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部分中文盐酸多塞平处方资料(仅供参考)

中文通用名称:盐酸多塞平

英文通用名称:Doxepin Hydrochloride

中文其他名称:
盐酸多虑平, 普爱宁, 盐酸多塞平片, 盐酸多塞平乳膏, 丽科宁, 盐酸多塞平注射液

英文其他名称:
Doxepine Hydrochloride, Xepin, Zonalon, Doxepin Hydrochloride Cream, Doxepin Hydrochloride Injection, Doxepin Hydrochloride Tablets

产品所属分类:精神障碍用药\抗抑郁药\三环类抗抑郁药

产品剂型:
片剂(14) 片剂(薄膜衣)(2) 片剂(糖衣)(1) 乳膏剂(2) 原料药(7) 注射液(3) 全部剂型(29)

作用:
Doxepin HCl 为dibenzoxepin衍生之三环化合物,虽是强效的H1和H2受体拮抗剂,可竞争性抑制组织胺之生物活化作用(biological activation),但其止痒作用的真正机转尚未清楚。   

药物动力学:
局部涂抹doxepin药膏後,全身吸收的程度未知。本药吸收进入血液循环後,大部份在肝脏进行 first-pass metabolism ,主要代谢成具有药理活性之desmethyldoxepin,进一步代谢成doxepin-N-oxide、hydroxydoxepin、hydroxydoxepin glucuronide等排泄於尿液中。Doxepin与desmethyldoxepin之排除半衰期分别为8-25小时及33.2-80.7小时,doxepin 之分布体积约为9-33L/kg,蛋白质结合率约79-84%,可通过BBB及胎盘,也会分泌至乳汁。   

适应症:
短期(≦8天)缓解湿疹性皮肤炎所引起之中重程度搔痒症状,包括异位性皮肤炎(atopic dermatitis)或单纯性慢性苔藓(lichen simplex chronicus)等。   

不良反应:
最常见之副作用为嗜睡,如有过度嗜睡之现象发生,须减少每日涂药次数或单位面积涂药量、减少涂药之体表面积或停止给药。其他较少见之副作用为口唇干燥、口渴、头痛、眩晕、情绪变化、味觉改变等。   
此外,常见之局部副作用为灼热与刺痛感,情况多属轻微,约25%较严重,少数患者可能因而须停药。其他较少见之副作用为痒感加剧、湿疹恶化、皮肤干燥紧绷、水肿、感觉异常等。

Generic Name: Doxepin

Brand Name: Adapin, Sinequan, Zonalon

What is Zonalon and for what Zonalon is used ?
Zonalon (Doxepin) relieves the itching that is associated with certain types of skin disorders. Generic doxepin skin cream is not yet available. Topical doxepin (DOX-e-pin) is used to relieve itching in patients with certain types of eczema. It appears to work by preventing the effects of histamine, which is a substance produced by the body that causes itching.

Zonalon (Doxepin), an antidepressant (mood elevator), is used to treat depression and anxiety. Zonalon also is used occasionally to treat chronic pain, peptic ulcer disease, and some skin conditions. Generic Zonalon capsules are available.

How to Take Zonalon
Zonalon (Doxepin) skin cream is for external use only; do not take by mouth. Follow the direction on the prescription label. Apply a thin film of cream to the affected area as often as directed. Do not cover the area. Use your doses at regular intervals. Do not use your medicine more often than directed.

Use Zonalon (Doxepin) medicine exactly as directed . Do not use more of it, do not use it more often, and do not use it for more than 8 days. Also, do not apply it to an area of skin larger than recommended by your doctor. To do so may increase the chance of side effects.

The dose of topical Zonalon (Doxepin) will be different for different patients. Follow your doctor's orders or the directions on the label . Generic Zonalon capsules is taken orally and may be taken with food to avoid stomach upset. Do not stop taking Generic Zonalon capsules abruptly without consulting with your doctor.

What are the Side Effects of Zonalon
Some common side effects reported with Zonalon Cream include:
•Burning, crawling, or tingling sensation of the skin.
•Worsening of eczema and itching.
•Swelling at the site of application.

Some common side effects reported with Generic Zonalon capsules include
•Headache
•Anxiety
•Nausea
•Blurred vision or eye pain
•Pain or difficulty passing urine
•Fever or chills, with increased sweating.
•Fatigue.
•Insomnia

Warnings and precautions for Zonalon
•Zonalon should not be taken while taking any other antidepressant, particularly an MAOI.
•Patients should be warned that the effects of other drugs acting on the central nervous system, such as alcohol, barbiturates and other CNS depressants, may be potentiated by Zonalon.
•Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of Zonalon in children with use in other age groups.
•Tell your doctor if you have ever had any unusual or allergic reaction to Zonalon. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
•If your skin problem does not improve after 8 days or if it becomes worse, check with your doctor.
•Zonalon has not been studied in pregnant women. However, doxepin has not been shown to cause birth defects or other problems in animal studies.
•Drinking alcohol or using these medicines with topical Zonalon may cause increased CNS depressant effects such as drowsiness.

What drugs may interact with Zonalon
Zonalon (Doxepin) can interact with many other medicines. An interaction can be very important or fairly insignificant. Make sure your prescriber or health care professional knows about all other medicines you are taking. The most important medicines are listed below:
•Any medicine that makes you drowsy or helps you sleep (such as antihistamines, tranquilizers, barbiturates, seizure medicine, muscle relaxants and others).
•Dextromethorphan (included in some cough medicines).
•Medicines for treating depression, especially monoamine oxidase inhibitors (MAOIs).
•Cimetidine.

What to do if you take Overdose of Zonalon medicine?
If you take overdose of Zonalon the seek medical attention immediately. For non emergencies, contact your local or regional poison control center.

What if you miss a dose of Zonalon?
If you miss a dose of Zonalon, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

How to Store Zonalon
•Keep out of the reach of children in a container that small children cannot open
•Store at room temperature below 27 degrees C (80 degrees F). Keep container tightly closed.
•Throw away any unused medicine after the expiration date.

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 详细处方信息以本药内容附件PDF文件(201882622072813.pdf)的“原文Priscribing Information”为准
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更新日期: 2017-11-08
附件:
201882622072813.pdf    





 
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