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当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

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  药店国别: 德国药房
产地国家: 德国
所属类别: 心血管系统药物->抗高血压药物
处方药:处方药
包装规格: 2毫克/片 28片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
勃林格殷格翰
生产厂家英文名:
BOEHRINGER INGELHEIM ESPAÑA
该药品相关信息网址1:
http://www.netdoctor.co.uk/medicines/100001751.html
该药品相关信息网址2:
http://www.drugs.com/uk/motens-tablets-2mg-spc-203.html
该药品相关信息网址3:
http://www.medicines.org.uk/EMC/medicine/298/SPC/Motens+Tablets+4mg/
原产地英文商品名:
MOTENS 2mg/tab 28tabs/box
原产地英文药品名:
LACIDIPINE
中文参考商品译名:
MOTENS 2毫克/片 28片/盒
中文参考药品译名:
拉西地平
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
hypertension
临床试验期:
完成
中文适应病症参考翻译1:
高血压
药品信息:

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部分中文拉西地平处方资料(仅供参考)

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通用名:拉西地平片

英文名:LACIDIPINE TABLETS

药品类别:抗高血压药
 
药理毒理:药理作用本品为二氢吡啶类钙离子拮抗剂,具高度选择性作用于平滑肌的钙通道,主要扩张周围动脉,减少外周阻力,降压作用强而持久。对心脏传导系统和心肌收缩功能无明显影响。并可改善受损肥厚左室的舒张功能,及抗动脉粥样硬化作用。可使肾血流量增加而不影响肾小球滤过率,可产生一过性但不明显的利尿和促尿钠排泄作用,因此能防止移植患者出现环孢素A诱发的肾脏灌注不足。本品为高度脂溶性,它在脂质部分沉积并在清除阶段不断释放到结合部位。这一特点使本品明显不同于其它钙拮抗药,其他钙拮抗药脂溶性低因而作用时间短。毒理作用:通过对Sparague-Dawley鼠及Beagle狗78周的急性,亚急性,慢性毒理研究显示, 最大重复剂量:鼠为32mg/kg(1个月)或20mg/kg(6个月),狗为8.5mg/kg(1个月)或5mg/kg(6个月)。与本品药效性相关的变化包括心动过速及便秘。通过狗60周口服给药毒性研究显示在最高剂量组群(1mg/kg和5mg/kg)可发现齿龈增生。 致癌、致畸及致突变通过研究本药无致癌性,致畸性及致突变性。【药代动力学】本品口服从胃肠道吸收迅速,由于肝脏广泛首过代谢,生物利用度为2%-9%,用更敏感分析方法平均为18.5%(4-52%)。吸收后95%药物与蛋白结合,主要是白蛋白及 α-1-糖蛋白。本品经肝脏代谢,代谢产物主要为吡啶类似物及羧酸类似物,2种为吡啶类,2种为羧酸类,主要通过胆道从粪便排出。其粪便排泄物中基本为代谢物。代谢谷峰比大于60%。 血浆清除率为1.1L/kg,稳态时终末T1/2为12-15小时。
 
药代动力学:本品口服从胃肠道吸收迅速,由于肝脏广泛首过代谢,生物利用度为2%-9%,用更敏感分析方法平均为18.5%(4-52%)。吸收后95%药物与蛋白结合,主要是白蛋白及 α-1-糖蛋白。本品经肝脏代谢,代谢产物主要为吡啶类似物及羧酸类似物,2种为吡啶类,2种为羧酸类,主要通过胆道从粪便排出。其粪便排泄物中基本为代谢物。代谢谷峰比大于60%。 血浆清除率为1.1L/kg,稳态时终末T1/2为12-15小时。
 
适应症:高血压。 

用法用量:
⑴成人 起始剂量4mg每日1次,在早晨服用较好。饭前饭后均可。如需要3-4周可增加至6mg,8mg一日一次。除非临床需要更急而超前投药。
⑵肝病患者初始剂量为2mg每日1次。

不良反应:
⑴最常见的有头痛,皮肤潮红,水肿,眩晕和心悸。
⑵少见无力,皮疹(包括红斑和搔痒),胃纳不佳,恶心,多尿。 ⑶极少数有胸痛和齿龈增生。

禁忌症:对本品成分过敏者。

注意事项:
⑴肝功能不全者需减量或慎用,因其生物利用度可能增加,而加强降血压作用。
⑵本品不经肾脏排泄,肾病患者无需修改剂量。
⑶一般不明显影响的实验室检查或血液学。但曾有一例可逆性碱性磷酸脂酶增加的报告。
⑷虽然本品不影响传导系统和心肌收缩,但理论上钙拮抗药影响窦房结活动及心肌储备,应予注意。窦房结活动不正常者尤应关注,有心脏储备较弱患者亦应谨慎。 

孕妇及哺乳期妇女用药:
(1)尚无资料证实本品对人类妊娠的安全性,孕妇应用须权衡利弊。
(2)本品及其代谢物由乳汁排出,应用本品最好不授乳或停用本品。
(3)本品有引起子宫肌肉松弛的可能性,临娩妇女应慎用。

儿童用药:本品尚无用于儿童的经验。

老年患者用药:老年人初始剂量为2mg,每日1次,必要时可增至4mg及6mg,每日1次。可以长期连续用药。 

药物相互作用:
⑴与β阻滞剂、利尿药合用,降压作用可加强。
⑵与西咪替丁合用,可使本品血药浓度增高。
⑶与地高辛合用,地高辛峰值水平可增加17%,对24小时平均地高辛水平无影响。
⑷与普萘洛尔合用,可轻度增加两者药时曲线下面积(AUC)。
⑸与华法令、甲苯磺丁脲、双氯芬酸、环孢菌素、安替比林等无特殊交叉反应。 

药物过量:尚无明确报道。但逾量可引起低血压及心动过速,此时需用输液及升压药。
 
贮藏:遮光、密封保存。

包装:(1)2mg (2)4mg

Motens 2mg and 4mg Tablets
1. WHAT MOTENS IS AND WHAT IT IS USED FOR
MOTENS contains a medicine called lacidipine. This belongs to a group of medicines called ‘calcium channel
 blockers’. MOTENS helps to relax your blood vessels so that they get wider. This helps the blood to flow more easily and lowers the blood pressure.

MOTENS tablets taken regularly as prescribed by your doctor will help to lower your blood pressure (to treat hypertension).

2. BEFORE YOU TAKE MOTENS
Do not take MOTENS if:
• You are pregnant, likely to get pregnant or are breast-feeding
• You are allergic (hypersensitive) to lacidipine, other calcium channel blocker medicines or any of the other ingredients of MOTENS (See section 6: Further information)
• You have the heart problem ‘aortic stenosis’. This is a narrowing of a valve in your heart, which restrict blood flow
• You have had a heart attack within the last month Do not take if any of the above apply to you. If you are not sure, talk to your doctor or pharmacist before taking MOTENS.
• You should stop taking MOTENS if you get chest pain (angina) or a fast, weak pulse, rapid shallow breathing, low blood pressure, cold clammy skin, blue lips or feel dizzy, faint, weak or sick

Take special care with MOTENS
Check with your doctor or pharmacist before taking MOTENS if:
• You have an uneven heart beat or any other heart problems
• You have or have ever had any liver problems

Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This includes herbal medicines. This is because MOTENS can affect the way some other medicines work. Also some other medicines can affect the way MOTENS works.

In particular, tell your doctor or pharmacist if you are taking any of the following medicines:
• Medicines for high blood pressure
• Medicines to control your heart beat (called‘anti-arrhythmics’)
• Medicines for depression called ‘tricyclic antidepressants’
• Sleeping tablets or sedatives
• Antibiotics
• Antihistamines - used for hayfever and other allergies
• Cimetidine - used for stomach problems
• Tetracosactide and corticosteroids

Tests
If you are having any blood tests, tell the person giving the test that you are taking this medicine. This is because MOTENS can affect results relating to your liver.

Taking MOTENS with food and drink
Do not take this medicine with grapefruit juice.

Pregnancy and breast-feeding
Do not take MOTENS if you are pregnant, likely to get

pregnant or are breast-feeding.

Driving and using machines
You may feel dizzy while taking MOTENS. If this happens,do not drive or use any tools or machines.

Important information about some of the ingredients of MOTENS
MOTENS contains lactose. If you have been told by your doctor that you cannot tolerate or digest some sugars, talk to your doctor before taking this medicine.

3. HOW TO TAKE MOTENS
Always take MOTENS exactly as your doctor has told you.

You should check with your doctor if you are not sure.

It is important to take the right number of tablets at the right time of day.
• The usual starting dose is 2 mg every morning.
• After 3-4 weeks this may be increased to 4 mg every morning.
• If necessary the dose may be increased again to 6 mg every morning which is the maximum daily dose.
• Swallow the tablets whole with a drink of water.
• Do not take with grapefruit juice.This medicine comes in a calendar pack marked with the days of the week. This means you can easily check that you have taken the dose on each day.

If you take more MOTENS than you should
If you take more of this medicine than you should, talk to a doctor or go to a hospital straight away. Take the medicine pack with you, even if there are no tablets left.

If you forget to take MOTENS
If you forget a dose in the morning, take it as soon as you remember it on the same day. However, if you remember the next day, take your normal dose on that morning. Do not take a double dose to make up for a forgotten dose.

4. POSSIBLE SIDE EFFECTS
Like all medicines, MOTENS can cause side effects,although not everybody gets them.

The side effects described below have been experienced by people taking MOTENS. They are listed as either common, uncommon, rare or very rare.

Common (affects less than 1 in 10 people, more than 1 in 100 people)
• dizziness, headache, fast or uneven heart beat (also called palpitations), flushing, swelling particularly of the ankles.

These side effects usually go away as treatment continues.
• fast heart beat
• upset stomach, feeling sick (nausea)
• rash, redness of the skin, itching
• an increase in the amount of water (urine) that you pass
• feeling weak
• changes in results of blood tests relating to your liver

Uncommon (affects less than 1 in 100 people, more than 1 in 1,000 people)
• chest pain (angina) including chest pain that is getting worse. Tell your doctor straight away if you have this serious side effect as you may need urgent medical treatment
• low blood pressure for example feeling faint, fainting
• swelling of the gums

Rare (affects less than 1 in 1,000 people, more than 1 in 10,000 people)
• rapid swelling of the face, mouth and throat which may cause difficulty breathing. Tell your doctor straight away if you have this serious side effect as you may need urgent medical treatment
• nettle rash (urticaria)
• depression
• muscle cramps

Very rare (affects less than 1 in 10,000 people)
• tremor

If any of the side effects gets troublesome or serious, or if you notice any side effects not listed in this leaflet, tell your doctor or pharmacist.

5. HOW TO STORE MOTENS
Keep out of the reach and sight of children.

The tablets should not be stored above 30°C and they should be kept in the original container to protect them from light. Do not remove any tablets from the foil until you are ready to take them.

Do not use MOTENS after the expiry date which is stated on the carton and the blister pack. The expiry date refers to the last day of that month.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. FURTHER INFORMATION
What MOTENS contains
The active substance is lacidipine. Each tablet contain either 2 mg or 4 mg. The other ingredients are lactose,povidone and magnesium stearate. The film coating contains hydroxypropylmethylcellulose and titanium dioxide.

What MOTENS looks like and contents of the pack
The 2 mg tablets are film coated, round and white in colour. They have the Boehringer Ingelheim Company logo on one side and the code “10L” on the other.

The 4 mg tablets are film coated, oval and white in colour.

They have the Boehringer Ingelheim Company logo on one side and the code “9L” on the other.

MOTENS tablets are available in blister packs of 28 tablets.

Marketing Authorisation Holder and Manufacturer
The Marketing Authorisations for MOTENS are held by:Boehringer Ingelheim Limited,

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更新日期: 2015-11-19
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