药品信息:
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(200821509291614.pdf)的“原文Priscribing Information”为准 --------------------------------------------------------------- 部分中文Januvia处方资料(仅供参考)
美国默克糖尿病治疗新药Januvia通过欧洲批准 美国默克制药公司每日用药一次的糖尿病治疗新药Januvia (sitagliptin)通过欧洲批准。该药是第一种通过欧洲批准的二肽酰肽酶4(DPP-4)抑制剂类糖尿病复方治疗药。
Januvia用于治疗2型糖尿病,它通过提高人体降糖素系统的机能而降低血糖水平。当人体血糖水平升高时,降糖素通过两种方式控制血糖水平:其一是促使胰腺释放胰岛素;其二是向肝脏发送信号以降低葡萄糖的生成。DPP-4抑制剂可以通过增加人体降糖素的活性而帮助2型糖尿病患者控制血糖水平特别值得指出的是,当单独使用Januvia效果不理想时,该药可与metformin联用,再结合饮食和运动而达到更好的疗效。同时,它还获准与thiazolidinedione联用。
默克公司生产的Januvia(Sitagli Ptin Phosphate monohydrate,磷酸西他列汀)获得加拿大健康署的批准,成为加拿大市场首个用于治疗2型糖尿病的二肽基肽酶-4(DPP-4)抑制剂类药物。根据审批结果,Januvia与另一种常用口服降糖药——二甲双胍联用,用于当2型糖尿病成年患者控制饮食或锻炼不能达到效果,以及单用二甲双胍无效时,更好地控制患者体内的血糖水平。
About JANUVIA JANUVIA is a once-daily pill that, along with diet and exercise, helps lower blood sugar levels in people with type 2 diabetes. It's a type of prescription diabetes medicine called a DPP-4 inhibitor (blocker). DPP-4 blockers enhance the body's own ability to control blood sugar levels.
A doctor may prescribe JANUVIA alone or together with certain other diabetes medicines to help control blood sugar.
JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in people with type 2 diabetes.
Important Information About JANUVIA JANUVIA has not been studied with insulin and should not be used to treat patients with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine) or used if you are allergic to JANUVIA. Your doctor may perform blood tests from time to time to measure how well your kidneys are working. If you have kidney problems, your doctor may prescribe lower doses of JANUVIA.
When JANUVIA is used with a sulfonylurea, low blood sugar (hypoglycemia) can occur. To avoid this risk, your doctor may prescribe lower doses of the sulfonylurea.
Allergic reactions, which may be serious, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have an allergic reaction, stop taking JANUVIA and call your doctor right away. The most common side effects include upper respiratory tract infection, stuffy or runny nose and sore throat, and headache.
Chemical Name: SITAGLIPTIN (si-ta-GLIP-tin)
Common uses This medicine is a dipeptidyl peptidase-4 (DPP-4) inhibitor used to treat type 2 diabetes in patients who cannot control blood sugar levels by diet and exercise. It is used along with diet and exercise. This medicine may be taken alone or in combination with certain other antidiabetic medicines.
Before using INFORM YOUR DOCTOR OR PHARMACIST of all prescription and over-the-counter medicine that you are taking. ADDITIONAL MONITORING OF YOUR DOSE OR CONDITION may be needed if you are taking digoxin. DO NOT START OR STOP any medicine without doctor or pharmacist approval. Inform your doctor of any other medical conditions including kidney problems, allergies, pregnancy, or breast-feeding. USE OF THIS MEDICINE IS NOT RECOMMENDED if you have type 1 diabetes or high blood ketone levels (diabetic ketoacidosis). Contact your doctor or pharmacist if you have any questions or concerns about taking this medicine.
Directions Follow the directions for using this medicine provided by your doctor. An additional patient information leaflet is available with this medicine. Read it carefully. Ask your doctor, nurse, or pharmacist any questions that you may have about this medicine. This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE at room temperature between 68 and 77 degrees F (20 and 25 degrees C) away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. CONTINUE TO TAKE THIS MEDICINE even if you feel well. Do not miss any doses. IF YOU MISS A DOSE OF THIS MEDICINE, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. DO NOT take 2 doses at once.
Cautions DO NOT TAKE THIS MEDICINE if you have had an allergic reaction to it or are allergic to any ingredient in this product. Laboratory and/or medical tests, including blood glucose, hemoglobin A1C, and kidney function, may be performed to monitor your progress or to check for side effects. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you are taking this medicine. It may be harder for you to control your blood sugar during times of stress such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or over-the-counter, check with your doctor or pharmacist. CAUTION IS ADVISED WHEN USING THIS MEDICINE IN THE ELDERLY because they may be more sensitive to the effects of the medicine. FOR WOMEN: IF YOU PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED in breast milk. IF YOU ARE OR WILL BE BREAST-FEEDING while you are using this medicine, check with your doctor or pharmacist to discuss the risks to your baby. CHECK BLOOD SUGAR LEVELS closely and ask your doctor before adjusting the dose of your diabetes medicine. MONITOR BLOOD GLUCOSE on a regular basis, as directed by your doctor.
Possible side effects SIDE EFFECTS that may occur while taking this medicine include headache, nausea, nasal congestion, runny nose, sore throat, or upper respiratory infection. If they continue or are bothersome, check with your doctor. An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, dizziness, or trouble breathing. If you notice other effects not listed above, contact your doctor, nurse, or pharmacist.
Drug interactions Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Use our drug interaction checker to find out if your medicines interact with each other. Check drug interactions
If you take too much IF OVERDOSE IS SUSPECTED, contact your local poison control center or emergency room immediately.
Additional information If your symptoms do not improve or if they become worse, check with your doctor. FOLLOW THE DIETARY PLAN provided by your doctor. Carry an identification card at all times that says you are diabetic. Monitor your blood sugar levels regularly according to your doctor's directions. If your blood sugar level is often higher or lower than it should be and you are taking this medicine according to directions, check with your doctor. DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT USE THIS MEDICINE for other health conditions. KEEP THIS MEDICINE out of the reach of children.
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(200821509291614.pdf)的“原文Priscribing Information”为准 --------------------------------------------------------------- |