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  药店国别: 澳大利亚药房
产地国家: 澳大利亚
所属类别: 作用于消化系统药物->胃肠外营养补充剂
处方药:处方药
包装规格: 100毫升
计价单位:
   
生产厂家英文名:
Fresenius Kabi
该药品相关信息网址1:
https://www.fresenius-kabi.com/457.htm
该药品相关信息网址2:
http://www.mims.com/hongkong/drug/info/Dipeptiven/
原产地英文商品名:
Dipeptiven Injection Solution 20% 100ml bottle (Minimum order qty: 10)
原产地英文药品名:
Alanyl Glutamine
中文参考商品译名:
Dipeptiven注射液 20% 100毫升 (最低订货量:10)
中文参考药品译名:
丙氨酰谷氨酰胺
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Glutamine in patients with parenteral nutrition
临床试验期:
完成
中文适应病症参考翻译1:
谷氨酰胺患者的肠外营养
药品信息:
药品名称:丙氨酰谷氨酰胺注射液 英文药名:Alanyl Glutamine Injection 商品名称:Dipeptiven 规格:50ML 100ML 250ML 产地:Fresenius Kabi Austria GmbH 适应症 适用于需要补充谷氨酰胺患者的肠外营养,包括处于分解代谢和高代谢状况的患者。 用法用量 本品是一种高浓度溶液,不可直接输注。在输注前,必须与可配伍的氨基酸溶液或含有氨基酸的输液相混合,然后与载体溶液一起输注。1体积的本品应与至少5体积的载体溶液混合(例如:100ml本品应加入至少500ml载体溶液),混合液体中本品的最大浓度不应超过3.5%。 剂量根据分解代谢的程度和氨基酸的需要量而定。胃肠外营养每天供给氨基酸的最大剂量为2克/KG体重,通过本品供给的氨基酸和谷氨酰胺量应计算在内,通过本品供给的氨基酸量不应超过全部氨基酸供给量的20%。 每日剂量:1.5-2.0ml/kg体重,每日最大剂量:2.0ml/kg体重。 丙氨酰谷氨酰胺注射液首先由德国费森尤斯•卡比公司于1995年在德国研制生产上市。 特点 谷氨酰胺是人体中含量最多的氨基酸,具有重要的生理作用。谷氨酰胺是生物合成核酸的必需前体物质,是蛋白质合成与分解调节物,谷氨酰胺在维持肠道机能,促进免疫机能,维持体内酸碱平衡及提高机体对应激的适应等方面都发挥着及其重要的作用,是L-谷氨酰胺的γ-羧基酰胺化物为条件必需性氨基酸。约占人体全部游离氨基酸的61%,是人体内含量最丰富的氨基酸。它既是重要的生化试剂,又是一种很有开发前途的新药。 本品为肠外营养的一个组成部分,N(2)-L-丙氨酰-L-谷氨酰胺可在体内分解为谷氨酰胺和丙氨酸,其特性可经由肠外营养输液补充谷氨酰胺。本双肽分解释放出的氨基酸作为营养物质各自储存在身体的相应部位并随机体的需要进行代谢。对可能出现体内谷氨酰胺耗减的病症,可应用本品进行肠外营养支持。 目前临床上已开始在常规营养支持配方中加入具有上调免疫功能的营养素,如谷氨酰胺、精氨酸和核苷酸等。谷氨酰胺(Gln)是一种条件必需氨基酸,是人体内含量最为丰富的游离氨基酸和重要的氮运载体和供体,而且是体内肠道上皮细胞、淋巴细胞等快速化生细胞的主要能量来源,有助于维持肠道的形态和免疫系统功能,是生物体合成核酸、蛋白质、嘌呤、嘧啶等的重要前体物质,也是蛋白质合成与分解的调节物。但由于Gln水溶性低、在溶液中不稳定,在加热灭菌时可生成有毒的谷氨酸和氨,因而不能直接作为药物,只有将其转化为稳定的衍生物才能充分发挥谷氨酰胺对人体的作用。 Peter Furst等发现丙氨酰谷氨酰胺是谷氨酰胺理想的替代品,并于1995年将其开发为肠外营养用药,有效地克服了谷氨酰胺在肠外营养中的使用缺点。丙氨酰谷氨酰胺是采用化学方法合成的,其纯度高,溶解度是Gln单体的20倍,在贮存和加热灭菌过程中结构也很稳定,进入体内后即可迅速分解成Gln而发挥作用。在应激状态下,如手术、创伤条件下,机体分解代谢亢进,蛋白质被分解和作为能量被利用,机体处于负氮平衡,体内合成谷氨酰胺严重不足。谷氨酰胺储备的减少,可导致感染、伤口愈合不良、免疫功能下降、肠粘膜通透性增高等严重后果,若能及时补充含丙氨酰谷氨酰胺的全肠外营养,则可改善氮平衡、增加蛋白质合成、减少肠道细菌移位。丙氨酰谷氨酰胺双肽具有促进肌肉蛋白合成,改善危重患者的临床与生化指标,维持肠道功能,保持机体氮平衡,增强免疫系统等作用,目前已在欧美等发达国家广泛使用。 Drug Name: alanylglutamine Injection The English name of the drug: Alanyl Glutamine Injection Product Name: Dipeptiven Specifications: 50ML 100ML 250ML Origin: Fresenius Kabi Austria GmbH Indications Applications that require glutamine supplementation in patients with parenteral nutrition, including in patients with high catabolic and metabolic conditions. Dosage This product is a high concentration of the solution, not directly infusion. Prior to infusion and must be compatible with the mixed amino acid infusion solution containing amino acids, or, together with the carrier solution and infusion. A volume of the product should be mixed with at least 5 volume of carrier solution (eg: 100ml This product should add at least 500ml carrier solution), the maximum concentration of the liquid in the product mix should not exceed 3.5%. The dose varies depending on the degree of amino acid catabolism requirement may be. The maximum dose of parenteral nutrition supply of amino acids to 2 grams a day / KG weight, the amount of amino acids and glutamine supplied by the product should be taken into account, the amount of amino acids supplied by the product should not exceed 20% of the total supply of amino acids . Daily dose :1.5-2 .0ml/kg weight, maximum daily dose: 2.0ml/kg weight. Alanylglutamine first injection by the German company Fresenius Kabi • developed and produced in 1995 listed in Germany. Feature Glutamine is the most abundant amino acids the human body has an important physiological role. Glutamine is required for the biosynthesis of nucleic acid precursors, are regulators of protein synthesis and degradation, glutamine in maintaining intestinal function, promote immune function, maintain body acid-base balance and improve the body adapt to stress and other aspects of play with its important role, is the L-glutamine γ-carboxyl amidation is conditionally essential amino acid composition. Free amino acids in the body accounts for about 61% of all, is the body's most abundant amino acids. It is important biochemical reagents, and is a very promising development of new drugs. This product is a component of parenteral nutrition, N (2)-L-alanyl-L-glutamine in the body can be decomposed as glutamine and alanine, their characteristics can be supplemented by parenteral nutrition infusion Valley amide. The dipeptide decomposition in the respective amino acids as nutrients stored in the corresponding parts of the body and requires random body metabolism. Of illness may occur in vivo depletion of glutamine, the FDA should be available parenteral nutritional support. Current clinical has begun adding nutrients increases immune function with conventional nutritional support in the formulation, such as glutamine, arginine, and nucleotides, etc.. Glutamine (Gln) is a conditionally essential amino acid content in the human body is the most abundant free amino acids and nitrogen carrier and an important donor, but the body of intestinal epithelial cells, lymphocytes and other major energy fast cell metaplasia source helps maintain the shape and function of the intestinal immune system, the organism is synthesized nucleic acids, proteins, purines, pyrimidines, etc. important precursors, but also regulation of protein synthesis and decomposition thereof. However, due to low water solubility Gln, unstable in solution, can generate toxic glutamic acid and ammonia in the heat sterilization, and can not be directly used as the drug, and only converted to a stable derivative of glutamine to be fully body effect. Peter Furst found that glutamine alanylglutamine is an ideal alternative, and in 1995 it was developed as parenteral nutrition administration, effectively overcome the disadvantages of the use of glutamine in parenteral nutrition. Alanyl glutamine play is chemically synthesized, and its high purity, Gln 20 times the solubility of the monomers in the process of heat sterilization and storage structure is stable, can be rapidly decomposed into the body into Gln effect. Under stress, the next such as surgery, trauma condition, hyperthyroidism body catabolism, proteins are broken down and used as energy is utilized, the body is in negative nitrogen balance, a serious shortage of glutamine synthesis in vivo. Reduce glutamine reserves, can lead to infection, poor wound healing, decreased immune function, intestinal permeability and other serious consequences, if replenish total parenteral nutrition containing alanylglutamine, you can improve nitrogen balance, increased protein synthesis, reduce bacterial translocation. Alanyl glutamine promote muscle protein synthesis, improving clinical and biochemical indicators of critically ill patients, maintain bowel function, maintaining body nitrogen balance, strengthen the immune system and so on, has been widely used in Europe and other developed countries.
更新日期: 2015-09-07
附件:
201473119074335.pdf    

 
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