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  药店国别: 俄罗斯药房
产地国家: 俄罗斯
所属类别: 作用于呼吸系统药物->感冒
处方药:处方药
包装规格: 50毫克/片 10片/瓶
计价单位:
   
生产厂家英文名:
Farmstandart Tomskhimfarm
该药品相关信息网址1:
http://www.arbidol.ru/
原产地英文商品名:
Arbidol 50mg 10 Tabs
中文参考商品译名:
阿比朵尔50毫克/片 10片/瓶
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Influenza
临床试验期:
完成
中文适应病症参考翻译1:
流行性感冒
药品信息:
阿比朵尔 (俄语:Арбидол,英语:Arbidol) 是一种抗病毒药物,由前苏联药物化学研究中心研制开发,主要适应症是A类、B类流感病毒引起的流行性感冒,同时对其他一些呼吸道病毒感染可能也有抗病毒活性。 应用/适应症 阿比朵尔的空间结构与另一种著名的抗流感病毒药物“达菲”(奥司他韦)类似,同时其合成路线则更加简短廉价,它的首次合成时间和首次上市时间也远早于达菲,可是目前的临床应用情况和影响力却远不如达菲。这一方面是因为达菲的专利持有人罗氏制药强大的商业运作能力,另一方面也因为阿比朵尔的抗病毒效果还没有得到公认,有报告称其“非常有效”,而另一些报告却对此表示怀疑。 该药的实验和临床报告主要来自俄罗斯及中国 ,据报道其对禽流感病毒的抑制能力和达菲(奥司他韦)一样有效,这意味着它有可能是一种比达菲更适应公众购买能力的,性价比更高的预防和控制禽流感的药物。甚至有报告称其体外细胞实验中表现出抗SARS病毒的活性。 有证据表明,阿比朵尔阻止RNA病毒感染可能比阻止DNA病毒感染更有效,流感病毒就是一种RNA病毒。阿比朵尔还是一种对抗丙型肝炎的候选药物(同样属于RNA病毒)。 作用机理 该药具有免疫调节剂的效果,同时对A型流感和B型流感还有特别的抗病毒活性。 它能阻止流感病毒外壳与宿主细胞细胞膜的接触、黏附和融合。另一方面,它还能诱导宿主细胞产生干扰素,并刺激体液反应和巨噬细胞的吞噬作用。 剂型 片剂或胶囊,每粒含有效成分盐酸阿比朵尔 50mg 或 100mg 。 药物动力学与用法 副作用主要是低概率的药物过敏,对于过量服用的情况未见报道,与其它药物联合用药的副作用未见报道。 盐酸阿比朵尔主要经肝脏以药物原形代谢,能迅速分布到全身各组织器官中,排泄以肝脏经胆汁向粪便中排泄为主,尿液中排泄量极少。 Arbidol (Russian : Арбидол, English : Arbidol) is an antiviral drug , the former Soviet chemical drugs developed by the research center , the main indication is a Class A , Class B influenza caused by influenza virus , while the other Some respiratory viral infections may also have anti -viral activity . Applications / Indications Arbidol spatial structure with another well-known anti-influenza virus medicine " Tamiflu" ( oseltamivir ) is similar , while its short synthetic route is more affordable, it 's the first time and the first time to market synthetic far too early on Tamiflu , but current clinical application and influence Queyuanburu Tamiflu . This is because the Tamiflu patent holder Roche strong commercial operational capacity , on the other hand because arbidol antiviral effect has not been recognized, there are reports saying " very effective " , while others report was skeptical. Experimental and clinical reports of the drug mainly from Russia and China , it was reported to inhibit the ability of the avian influenza virus and Tamiflu ( oseltamivir ) as effective , which means that it may be more responsive to the public a比达菲purchasing power , more cost-effective drug prevention and control of avian influenza. There are even reports saying vitro experiments showed activity against SARS virus . There is evidence that arbidol prevents RNA virus infections may be more effective than blocking DNA virus, influenza virus is an RNA virus . Arbidol also a fight against hepatitis C drug candidate ( RNA virus belonging to the same ) . Mechanism The drug has an immunomodulator effect , while the influenza A and influenza B and a special antiviral activity. It prevents contact with the influenza virus with the host cell membrane shell , adhesion and fusion . On the other hand , it can also induce host cells to produce interferon and stimulate humoral and phagocytosis of macrophages . Formulations Tablets or capsules, each containing the active ingredient Arbidol 50mg or 100mg. Pharmacokinetics and usage The main side effect is a low probability of drug allergy, in the case of overdose has not been reported , the side effects of combination therapy with other drugs have not been reported . Arbidol mainly by the liver to metabolize the drug prototype that can be quickly distributed to body tissues and organs , and excretion of bile from the liver mainly excreted in feces , urine excretion rarely .
更新日期: 2014-04-07
附件:
201451819044018.pdf    

 
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