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  药店国别: 日本药房
产地国家: 日本
所属类别: 抗癌药物->治疗白血病药物
处方药:处方药
包装规格: 30毫克/胶囊 100胶囊/盒
计价单位:
   
生产厂家英文名:
Nippon Kayaku
该药品相关信息网址1:
http://www.igenericdrugs.com/gd.cgi?notran=1&s=Bestatin&search=SEARCH
原产地英文商品名:
Bestatin 30mg/capsule 100caps
原产地英文药品名:
Ubenimex
中文参考商品译名:
倍司他定 30毫克/胶囊 100胶囊/盒
中文参考药品译名:
乌苯美司
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Leukemia
英文适应病症2:
Cancer
临床试验期:
完成
中文适应病症参考翻译1:
白血病
中文适应病症参考翻译2:
肿瘤
药品信息:
药品英文名 UBENIMEX 药品别名 倍司他定、贝他定 乌苯美司 BESTATIN 药物剂型 胶囊:10mg,30mg/粒。 药理作用 本品是从橄榄网状链球菌培养液中提取的亮氨酸氨肽酶和氨肽酶β的抑制物,它是一种低分子免疫激活剂。实验证明它可激活巨噬细胞对多种小鼠肿瘤的细胞毒性,调节T淋巴细胞亚群的平衡,使肿瘤患者TH/TS比值上升,并促进其白细胞介素IL-1和IL-2产生。本品通过T淋巴细胞介导和NK细胞数量及其活性的提高而呈现抗肿瘤作用。由于它能促进骨髓干细胞的增殖和分化,故能减轻抗癌药物或其他因素(如放射线)对骨髓造血功能的抑制作用,并促进抗癌治疗后外周血细胞的回复。 药动学 成人口服本品30mg单剂量后血药浓度在1~2h内达峰值,以后呈双相性下降。半衰期为0.98~1.5h。体内分布以肝、肾药浓度较高,其次为脾、肠系膜、肾门淋巴结、肾上腺等。24h内本品原形及其代谢物自尿中排泄的量约90%。 适应证 临床可用作抗白血病或抗肿瘤的辅助治疗。如将本品与细胞毒类抗癌药联合应用,有可能延长肿瘤患者的寿命和(或)降低抗肿瘤药物的毒性。 不良反应 少数病人服药后出现皮疹、肝功能异常、恶心、呕吐、腹痛、腹泻等副作用,停药后便逐渐消失。 用法用量 口服:成人每天30mg,可顿服或分2~3次 English name drugs UBENIMEX   Drug Aliases Division times he will , he will be Tony ubenimex BESTATIN   Pharmaceutical dosage forms Capsules : 10mg, 30mg / tablets.   Pharmacological effects This product is from S. mesh olive extract broth leucine aminopeptidase and aminopeptidase inhibitors of β , which is a low molecular immune activator . Experiments show that it can activate a variety of murine macrophage tumor cytotoxicity , adjust the balance of T lymphocyte subsets , so that cancer patients TH / TS ratio increased , and promote their interleukin IL-1 and IL-2 production . This product is mediated by T lymphocytes and NK cells and increase the number of active and showed anti-tumor effects . Because it can promote the proliferation and differentiation of bone marrow stem cells , and it could reduce the anti-cancer drugs or other factors ( such as radiation ) inhibition of bone marrow and peripheral blood cells promote the anti-cancer treatment response .   Pharmacokinetics After oral administration of 30mg adult single dose peak plasma concentration within 1 ~ 2h, after biphasic decreased. Half-life of 0.98 ~ 1.5h. Vivo distribution to the liver, kidneys higher drug concentrations , followed by the spleen , mesenteric , renal hilar lymph nodes, adrenal . Within 24h This product prototype and its metabolites from the urinary excretion of about 90%.   Indications Clinically useful anti-tumor or anti- leukemic adjuvant therapy. If this product with cytotoxic anticancer drugs in combination , it is possible to extend the life of cancer patients and ( or ) reduce the toxicity of anticancer drugs .   Adverse reactions Rash, liver function abnormalities , nausea , vomiting, abdominal pain, diarrhea and other side effects after taking a few patients , stopping after disappearing.   Dosage Oral : Adults 30mg, Dayton clothing or can be 2 to 3 times a day
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