您好,欢迎光临世界标品! 登录 注册(订药物标准品请用邮件联系我们)

SCITEK INTERNATIONAL (H.K.) LIMITED
Email: sciteck.hongkong@gmail.com
 

当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

世界标品医药目录搜索(中英文):
世界各国官方药品目录搜索(英文):
世界标品医药知识搜索(中英文):

联系方式
国内客服电话:
国际免费电话:

咨询邮箱:
scimed.shanghai@shijiebiaopin.com
info@shijiebiaopin.com
pharmacy.shijiebiaopin1@gmail.com
pharmacy.shijiebiaopin2@gmail.com

  药店国别: 加拿大药房
产地国家: 加拿大
所属类别: 激素内分泌药物->生长激素
处方药:处方药
包装规格: 5.3毫克 5支
计价单位:
   
生产厂家中文参考译名:
辉瑞制药
生产厂家英文名:
Pfizer
该药品相关信息网址1:
http://www.igenericdrugs.com/gd.cgi?notran=1&s=Genotropin&search=SEARCH
原产地英文商品名:
Genotropin Syringe 5.3mg 5Units
原产地英文药品名:
Somatropine
中文参考商品译名:
健豪宁注射剂 5.3毫克 5支
中文参考药品译名:
基因重组人生长激素
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Treating certain children or adults whose bodies do not produce enough growth hormone
英文适应病症2:
Treat certain children who are not growing normally due to Turner syndrome or Prader-Willi syndrome, or who were born small for gestational age (SGA)
临床试验期:
完成
中文适应病症参考翻译1:
治疗某些儿童或成人的身体不能产生足够的生长激素
中文适应病症参考翻译2:
治疗某些孩子谁不因特纳综合征或普拉德 - 威利综合征,或出生小于胎龄儿(SGA)
药品信息:

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(201412023301717.pdf)的“原文Priscribing Information”为准
---------健豪宁处方资料(仅供参考)

2001年7月FDA批准了法玛西亚的生长激素注射剂——Genotropin。1995年8月该公司的Genotropin Lyophilized粉剂获得批准,Genotropin是继之被批准的第二种生长激素制剂。

Genotropin适用于妊娠期体形偏小,并且两岁时身高仍明显低于同龄人的患儿。此药须长期应用。

妊娠期体形小,即SGA(Small for Gestational Age),指体形小于根据孕周预测得出的数值。每一年,在两岁的儿童中,约有12000名有SGA病史并且身高仍明显低于同龄人的患儿,如果不进行医疗干预这些患儿的身高将不能达到正常范围。

1995年Genotropin Lyophilized粉剂被批准用于生长激素缺乏(GHD)的儿科患者,目前此药还可用于成人GHD的替代治疗,最近Genotropin又被批准用于患有Prader-Willi综合征的儿科患者。Prader-Willi综合征是一种基因缺陷引起的生长障碍性疾病。

在对此药进行的临床试验中,报告的副作用包括:注射部位反应、头痛、浮肿、易怒、关节痛、肌肉痛和脱发。

Genotropin是一种以重组DNA为基础的多肽类激素。其对人体的作用与自体分泌的生长激素相同。对于患有GHD或Prader-Willi综合征的儿科患者,此药可以引发与用量呈线性关系的增高,并且可以使胰岛素样生长因子(IGF-1)的浓度正常化。成年GHD患者使用Genotropin治疗,能够减少脂肪组织,增加肌肉组织,调节脂肪代谢,并且维持IGF-1的浓度

药理作用

促进全身蛋白质合成,纠正手术等创伤后的负氨平衡状态,刺激免疫球蛋白合成,刺激淋巴样组织,巨噬细胞和淋巴细胞的增殖,增强抗感染能力;刺激烧伤创面及切口胶原细胞、巨噬细胞分裂增殖,加速伤口愈合。

吸收、分布、清除

皮下、肌肉注射级药效果相同,血浆浓度在注射3-5小时后达到最高峰,半衰期为2-3小时。肝、肾代谢清除,成人快于儿童;尿中排泄未经代谢的GH极其微量。血洲循环中几乎都与高亲和力的GH结合蛋白结合在一起,使其在血清中的半衰期延长。

适应症

对于手术、创伤、烧伤、严重感染和慢性消耗性疾病患者,注射本品可逆转机体的负氮平衡,加速伤口愈合,改善预后。

用法

使用前将冻干的rhGH制剂用附带的注射用水溶解,注意应使用水缓慢地注射药品,以减少溶解过程中泡沫的产生。药品全部溶解需2分钟,在此期间切忌剧烈振荡。

不良反应

常见注射部位一过性局部皮肤反应(疼痛、发麻、发红及肿胀等)。

体液潴留的症状(周围水肿、关节痛、肌痛)。

在治疗开始后, 这些副作用发生较早,且多能耐受。

禁忌症

有肿瘤进展症状的患者慎用。

注意事项

用基因重组人生长激素治疗应该由相当资格的医师指导。

对糖尿病患者可能需要调整抗糖尿药物的剂量。

对由脑瘤造成生长激素缺乏的病人或有颅内伤病史的患者,必须注意观察潜在疾病进展及复发的可能性。

由于生长激素可导致过度胰岛素状态,因此,必须注意病人是否有葡萄糖耐量减低的现象。

请勿过量用药,一次注射过量的生长激素可导致低血糖继这出现高血糖。

储存

2-8℃保存,有效期暂定为两年,在室温下可以存放一个月,配制成的药液,可置于2-8℃的冰箱中保存72小时

Genotropin - Somatropin is a form of human growth hormone. Human growth hormone is important in the body for the growth of bones and muscles. Somatropin is used to treat growth failure in children and adults who lack natural growth hormone, and in those with chronic kidney failure, Noonan syndrome, Turner syndrome, Prader-Willi syndrome, short stature at birth with no catch-up growth, and other causes. Somatropin is also used to prevent severe weight loss in people with AIDS, or to treat short bowel syndrome.

Somatropin may also be used for purposes not listed in this medication guide.

Used for: Treating certain children or adults whose bodies do not produce enough growth hormone. It is also used to treat certain children who are not growing normally due to Turner syndrome or Prader-Willi syndrome, or who were born small for gestational age (SGA). It may also be used for other conditions as determined by your doctor.

Genotropin is a growth hormone. It works by stimulating growth in patients who do not make enough natural growth hormone.

Used in the treatment of dwarfism and growth failure, growth hormone (hGH) stimulates skeletal growth in pediatric patients with growth failure due to a lack of adequate secretion of endogenous GH. Skeletal growth is accomplished at the epiphyseal plates at the ends of a growing bone. Growth and metabolism of epiphyseal plate cells are directly stimulated by GH and one of its mediators, IGF-I (insulin-like growth factor).

Indication: For treatment of dwarfism, acromegaly and prevention of HIV-induced weight loss

Somatotropin refers to the growth hormone produced natively and naturally in animals, whereas the term somatropin refers to growth hormone produced by recombinant DNA technology, and is abbreviated "rhGH" in humans.

Adults: Replacement therapy in adults with pronounced growth hormone deficiency. Children: Growth disturbances due to insufficient secretion of growth hormone and growth disturbances associated with Turner\'s syndrome.

Growth disturbance caused by insufficient secretion of endogenous growth hormone or by gonadal dysgenesis (Turner\'s syndrome).

Growth disturbance due to insufficient secretion of growth hormone or associated with gonadal dysgenesis or Turner\'s syndrome which is a chromosome aberration. Replacement therapy in adults with prolonged growth hormone deficiency.

Adults: Replacement therapy in adults with pronounced growth hormone deficiency (GHD). Adult Onset: Patients who have severe GHD associated with multiple hormone deficiencies as a result of known hypothalamic or pituitary pathology and who have at least 1 known deficiency of a pituitary hormone, not being prolactin. These patients should undergo appropriate dynamic test in order to diagnose or exclude a growth hormone deficiency. Children: Growth disturbance due to insufficient secretion of GHD and growth disturbance associated with Turner syndrome or chronic renal insufficiency. Growth disturbance (current height SDS below -2.5 and parental adjusted height SDS below -1) in short children born SGA, with a birth weight and/or length below -2 SD, who failed to show catch-up growth (HV SDS <0 during the last year) by 4 years of age or later. Prader-Willi syndrome (PWS), for improvement of growth and body composition. The diagnosis of PWS should be confirmed by appropriate genetic testing. Childhood Onset: Patients who have GHD during childhood as a result of congenital, genetic, acquired or idiopathic causes. Patients with childhood onset GHD should be re-evaluated for growth hormone secretory capacity after completion of longitudinal growth. In patients with a high likelihood for persistent GHD ie, a congenital cause or GDH secondary to a pituitary/hypothalamic disease or insult, IGF-I SDS <2 off growth hormone treatment for at least 4 weeks should be considered sufficient evidence of profound GHD. All other patients will require IGF-I assay and 1 growth hormone stimulation test.

Replacement of endogenous GH in adults with GH deficiency (GHD) of either childhood- or adult-onset etiology. Long-term treatment of children with short stature associated with Turner syndrome. Treatment of children with growth failure caused by Prader-Willi syndrome; treatment of growth failure in children born small for gestational age who fail to manifest catch-up growth by 2 yr of age. Long-term treatment of children with idiopathic short stature.

Growth hormone (GH) is a protein-based peptide hormone. It stimulates growth, cell reproduction and regeneration in humans and other animals. Growth hormone is a 191-amino acid, single-chain polypeptide which is synthesized, stored, and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland. Somatotropin refers to the growth hormone produced natively and naturally in animals, whereas the term somatropin refers to growth hormone produced by recombinant DNA technology, and is abbreviated "HGH" in humans.

更新日期: 2013-12-16
附件:
 
调控比例: 100%
订购表单下载
Copyrights © 2010,2011,2012 www.ShiJieBiaoPin.com, Inc., All rights Reserved www.ShiJieBiaoPin.com, Inc.
客服工作时间:太平洋时间18:00-24:00
国内客服电话:     国际免费电话:
友情提示:以上电话为免费电话,无需您承担任何费用,世界标品提供中文客服,请您放心拨打!
电子邮箱:sciteck.hongkong@gmail.com, 15901965168@163.com