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  药店国别: 美国药房
产地国家: 美国
所属类别: 骨科药物->类风湿关节炎
处方药:处方药
包装规格: (50毫克:0.2毫克)/片 60片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
辉瑞制药
生产厂家英文名:
Pfizer
该药品相关信息网址1:
http://www.arthrotec.com/
该药品相关信息网址2:
http://www.drugs.com/arthrotec.html
该药品相关信息网址3:
http://www.rxlist.com/arthrotec-drug.htm
原产地英文商品名:
ARTHROTEC (50mg; 0.2mg) 60 Tablets
原产地英文药品名:
DICLOFENAC SODIUM/MISOPROSTOL
中文参考商品译名:
奥湿克 (50毫克:0.2毫克)/片 60片/盒
中文参考药品译名:
双氯芬酸钠/米索前列醇
原产地国家批准上市年份:
1997/12/24
英文适应病症1:
Inflammatory
英文适应病症2:
Osteoarthritis
英文适应病症3:
Rheumatoid arthritis
英文适应病症4:
Ankylosing spondylitis
临床试验期:
完成
中文适应病症参考翻译1:
炎症
中文适应病症参考翻译2:
骨关节炎
中文适应病症参考翻译3:
类风湿性关节炎
中文适应病症参考翻译4:
强直性脊椎炎
药品信息:

部分中文奥湿克信息资料(仅供参考)
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 详细处方信息以本药内容附件PDF文件(20096200455123.pdf)的“原文Priscribing Information”为准
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【别名】双氯芬酸钠-米索前列醇片,奥湿克

【外文名】Diclofenac-Misoprostol Tab, Arthrotec

【成分】双氯芬酸钠50mg,米萦前列醇200ug

【适应症】类风湿性和骨关节炎,强直性脊椎炎。

【用量用法】成人1片bid-tid。 与食物一起服用,整片吞服,不能嚼碎。

【禁忌】胃肠道出血者,妊娠妇女和计划怀孕的妇女。

【不良反应】腹痛,腹泻,恶心,消化不良,腹胀,呕吐,胃炎,便秘,皮疹,头晕,头痛,月经过多。肝病可出现S-GPT、S-GOT和胆红素增高。偶见肾脏损害。

【注意事项】哺乳妇女慎用。

ARTHROTEC is indicated for patients who require a nonsteroidal anti-inflammatory drug (NSAID) together with misoprostol.
The diclofenac component of ARTHROTEC is indicated for the treatment of osteoarthritis and rheumatoid arthritis. The misoprostol component of ARTHROTEC is indicated for the prophylaxis of NSAID-induced gastric and duodenal ulceration.

GENERIC NAME: diclofenac and misoprostol
BRAND NAME: Arthrotec
DRUG CLASS AND MECHANISM: Arthrotec is a combination of diclofenac and misoprostol. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen (Motrin; Advil), naproxen (Naprosyn), and others. Diclofenac, like other NSAIDs work by inhibiting the production of prostaglandins. Prostaglandins are a related family of chemicals that are produced by the cells of the body and have several important functions. They promote inflammation, pain, and fever, support the function of platelets that are necessary for the clotting of blood, and protect the lining of the stomach from the damaging effects of acid. Prostaglandins are produced by the enzyme cyclooxygenase (Cox). There actually are two Cox enzymes, Cox-1 and Cox-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever. However, only Cox-1 produces prostaglandins that support platelets and protect the stomach. Diclofenac blocks both Cox enzymes and reduces prostaglandins throughout the body. As a consequence, ongoing inflammation, pain, and fever are reduced. Since prostaglandins that protect the stomach and support platelets and blood clotting also are reduced, NSAIDs can cause ulcers in the stomach and promote bleeding. Misoprostol is a synthetic (man-made) prostaglandin that stimulates secretion of mucus in the gastrointestinal tract. Mucus protects the lining of the stomach from acid. Misoprostol has been shown to reduce the frequency of ulcers of the stomach caused by NSAIDs. Arthrotec was approved by the FDA in December, 1997.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tablets (diclofenac/misoprostol): Arthrotec 50 (50 mg/200 礸) , Arthrotec 75 (75 mg/200 礸) .

STORAGE: The tablets should be kept at room temperature, 15-30癈 (59-86癋).

PRESCRIBED FOR: Arthrotec is used for treating signs and symptoms of rheumatoid arthritis or osteoarthritis in patients at risk for developing ulcers from NSAIDs.

DOSING: For osteoarthritis the recommended dose is Arthrotec 50 given three times daily. Patients who cannot tolerate this regimen may be treated with Arthrotec 50 or 75 twice daily. The recommended dose for treating rheumatoid arthritis is Arthrotec 50 given 3-4 times daily. If this regimen is not tolerated, Arthrotec 50 or 75 twice a day may be used. Taking Arthrotec with food may reduce stomach upset. It is recommended that Arthrotec not be taken with alcohol because of the increased risk for ulcers.

DRUG INTERACTIONS: (Please also see the monographs for diclofenac.) Diclofenac is generally used with caution in patients taking blood thinning medications (anticoagulants), such as warfarin (Coumadin), because of the increased risk of bleeding. Patients taking lithium can develop toxic blood levels of lithium because diclofenac may inhibit the elimination of lithium from the body by the kidney. Side effects from methotrexate and cyclosporine also may be increased by diclofenac. Diclofenac may reduce the effectiveness of antihypertensives because it causes or worsens high blood pressure.

PREGNANCY: Since misoprostol can cause abortions, Arthrotec should not be used by women who are pregnant. Avoid pregnancy for 1 month or 1 menstrual cycle after discontinuing Arthrotec.

NURSING MOTHERS: Arthrotec is not recommended for use by nursing mothers.

SIDE EFFECTS: Arthrotec has the side effects of diclofenac and misoprostol. The most common side effects are stomach pain, diarrhea, dyspepsia, nausea and flatulence. Diarrhea and abdominal pain may resolve after 2-7 days. Magnesium containing antacids worsen diarrhea caused by misoprostol. Taking Arthrotec with food and avoiding antacids containing magnesium may reduce the occurrence of diarrhea. Serious side effects include gastrointestinal ulcers and bleeding; liver dysfunction; severe skin reactions. Severe bronchospasms may occur in patients with aspirin-sensitive asthma. Like other NSAIDS Arthrotec may cause heart attacks and strokes; accumulation of fluid and worsen heart failure; cause or worsen hypertension and kidney failure.

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 详细处方信息以本药内容附件PDF文件(20096200455123.pdf)的“原文Priscribing Information”为准
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更新日期: 2013-10-09
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