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 详细处方信息以本药内容附件PDF文件（200912201034039.pdf）的“原文Priscribing Information”为准
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What is Ziana?

Ziana is a gel containing a combination of clindamycin and tretinoin. Clindamycin is an antibiotic. It fights bacteria in the body.

Tretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly.

Ziana is used to treat severe nodular acne in adults and children who are at least 12 years old.

Ziana may also be used for purposes other than those listed in this medication guide.

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Important information about Ziana

Avoid getting Ziana in your eyes, mouth, or nose (or in the creases of your nose), or on your lips. If it does get into any of these areas, wash with water. Do not apply Ziana to sunburned, windburned, dry, chapped, irritated, or broken skin.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

Although Ziana is applied to the skin, your body may absorb enough clindamycin to cause serious side effects.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Ziana can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

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What should I discuss with my health care provider before using Ziana?

Although Ziana is applied to the skin, your body may absorb enough clindamycin to cause serious side effects.

Do not use Ziana if you are allergic to clindamycin (Cleocin, Clina-Derm, Clindets), or tretinoin (Renova, Retin-A, Tretin-X), or if you have:

1)inflammation of your intestines (also called enteritis);

2)ulcerative colitis; or

3)if you have ever had severe diarrhea caused by antibiotic medicine.

Before using Ziana, tell your doctor if you are allergic to any drugs, or if you have a history of stomach or intestinal disorders. You may not be able to use the medication, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. Ziana may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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 详细处方信息以本药内容附件PDF文件（200912201034039.pdf）的“原文Priscribing Information”为准
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于20091202更新