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  药店国别: 日本药房
产地国家: 日本
所属类别: 作用于消化系统药物->治疗胃食管反流药物
处方药:处方药
包装规格: 20毫克/片 14片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
日本卫材株式会社
生产厂家英文名:
Eisai Co., Ltd
该药品相关信息网址1:
http://www.eisai.com/
原产地英文商品名:
Pariet Gastroresistent tablet 20mg/tab 14tabs/box
原产地英文药品名:
Rabeprazole Sodium
中文参考商品译名:
波利特肠溶片 20毫克/片 14片/盒
中文参考药品译名:
雷贝拉唑钠
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Zollinger-Ellison syndrome,ZES
英文适应病症2:
Treatment of symptomatic erosive or ulcerative GORD
英文适应病症3:
Treatment of active duodenal ulcer and active benign gastric ulcer
临床试验期:
完成
中文适应病症参考翻译1:
佐-埃综合征
中文适应病症参考翻译2:
治疗症状腐蚀性或溃疡性GORD
中文适应病症参考翻译3:
治疗活动期十二指肠溃疡和活动期良性胃溃疡
药品信息:

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 详细处方信息以本药内容附件PDF文件(20104706135232.pdf)的“原文Priscribing Information”为准
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部分中文Pariet处方资料(仅供参考)

     雷贝拉唑钠 Rabeprazole Sodium
     别名:
波利特,安斯菲,瑞波特。
    
     质子泵抑制剂类药雷贝拉唑钠(rabeprazole sodium,Pariet)用于佐-埃综合征(Zollinger-Ellison syndrome,ZES)的治疗。ZES是由于胰腺或小肠胃泌素瘤分泌高水平胃泌素导致的胃酸水平升高,从而引发多种胃肠溃疡。

    对于与幽门螺旋杆菌有关的胃和十二指肠溃疡来说,抑制酸性对提高杀菌疗效非常重要。临床数据显示,通过创造一个弱酸环境,雷贝拉唑钠能够克服pH值障碍,从而消灭幽门螺旋杆菌(1)(2)。

    主要专家都对这种新的指征表示欢迎,它向感染幽门螺旋杆菌的患者提供了迅速而且可预测的酸性抑制和抗生素值的最佳组合,从而达到完全消灭机体细菌的效果。

    在欧洲,Pariet*(雷贝拉唑钠)已经获得批准与相应的抗菌治疗方案一道,用于消灭消化道溃疡病患者的幽门螺旋杆菌。建议使用以下剂量进行7天的治疗:Pariet*(雷贝拉唑钠)20毫克,每日两次;克拉霉素500毫克,每日两次;羟氨苄青霉素1克,每日两次。

    Pariet*(雷贝拉唑钠)已经被指定用于治疗症状腐蚀性或溃疡性GORD,作为腐蚀性或溃疡性GORD的维持疗法,以及用于治疗活动期十二指肠溃疡和活动期良性胃溃疡。与其它PPI(3)相比,Pariet*(雷贝拉唑钠)已经显示了更快、更强和更加持久的酸性抑制作用,(4)从第一天开始(5)(6)(7)就使GORD患者缓解症状。

    Pariet有规格为10mg和20mg的2种缓释肠溶片,一日1次用药。该药用于ZES治疗时剂量为60mg/次、一日1次。该药不宜用于对雷贝拉唑及其它取代苯并咪唑类质子泵抑制剂以及片剂中的其它成分过敏的患者。该药最常见的不良反应为头痛,其它不良反应有便秘、腹泻、晚间难以入睡、头晕、胃灼热、皮疹、胃痛和体重减轻等。

    Pariet于1998年被欧盟批准用于症状性胃食管反流病的治疗,由卫材的子公司分别在英国和德国销售,杨森公司(Janssen-Cilag)负责该药在其他欧盟国家的销售。1997年该药首次投放日本市场。1999年该药以Aciphex为商品名在美国上市。目前,该药已经在全球72个国家上市。


Pariet
Generic Name: Rabeprazole sodium
Product Name: Pariet
•Indication of Pariet
•Action of Pariet
•Dose Advice of Pariet
•Schedule of Pariet
•Common side effects of Pariet
•Uncommon side effects of Pariet
•Reference

Indication of Pariet:
Pariet is used for the treatment of:
•Stomach ulcers
•Ulcers in the duodenum (the area of the small intestine that lies just after the stomach)
•The symptoms of gastroesophageal reflux disease
In combination with two antibiotic agents, Pariet is used for the eradication of Helicobacter pylori. Helicobacter pylori is a bacteria that is strongly linked to stomach ulcerations and chronic gastritis.

Action of Pariet:
Pariet relieves the symptoms of reflux and ulcers by slowing down the secretion of acid by the cells that line the stomach. It does this by inhibiting a single type of enzyme (a protein that allows other chemical reactions to occur faster) called a 'proton pump' that is needed to produce acid. So, by inhibiting this enzyme, the final stage in acid production is stopped.
The acid suppression effect of Pariet occurs very quickly (within 2-4 hours) and lasts up to 23 hours after the first dose. Normal acid production can be decreased by 69%. Also at 23 hours, the amount of acid produced when eating food (which is when a lot of acid is created) is reduced by 82%.
The symptoms of many of the conditions treated by Pariet are very similar. Your doctor can sometimes recommend a medical procedure called an endoscopy, where a flexible fibre-optic tube is passed down the throat into the stomach, allowing the gastroenterology doctor to see the exact cause of the symptoms. People are put into a light sleep for the few minutes it takes to do the test, and most people have no recollection of it afterwards.

Dose Advice of Pariet:
The dosage of Pariet will depend on what condition is being treated. The usual doses are as follows:

Condition Dose
Active reflux:20mg once daily for 4-8 weeks. If the symptoms persist, then 20mg twice daily (total 40mg per day) can be used for a further 4 weeks.
Maintenance of reflux treatment:Dosage should be lowered to the minimum amount, usually between 10-20mg daily.
Symptomatic treatment of reflux:Dosage usually begins at 10mg per day, increasing to 20mg per day if there is no response. Once symptoms have resolved, subsequent symptom control can be achieved using a regimen of one 10 mg tablet taken once daily when needed.
Treatment of duodenal ulcers:20mg once a day for 4-8 weeks.
Treatment of stomach ulcers:20mg once a day for 6-12 weeks.
Eradication of Helicobacter pylori bacteria:Usually 20mg of Pariet twice a day, in combination with two antibiotics.
The use of Pariet is not recommended in children.
Doses do not need to be adjusted for elderly patients.


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 详细处方信息以本药内容附件PDF文件(20104706135232.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2013-03-26
附件:
20104706135232.pdf    



 
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