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  药店国别: 土耳其药房
产地国家: 土耳其
所属类别: 神经系统药物->治疗精神分裂症
处方药:处方药
包装规格: 5毫克/片 28片/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
百时美施贵宝
生产厂家英文名:
BRISTOL MYERS SQUIBB
该药品相关信息网址1:
http://www.abilify.com/
该药品相关信息网址2:
http://www.drugs.com/abilify.html
该药品相关信息网址3:
http://www.rxlist.com/abilify-drug.htm
原产地英文商品名:
ABILIFY 5mg/tab 28tabs/bottle
原产地英文药品名:
ARIPIPRAZOLE
原产地英文化合物名称:
7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
中文参考商品译名:
安立复 5毫克/片 28片/瓶
中文参考药品译名:
阿立哌唑
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Schizophrenia
英文适应病症2:
Anxiety, depression
英文适应病症3:
Acute manic depression
临床试验期:
完成
中文适应病症参考翻译1:
精神分裂症
中文适应病症参考翻译2:
焦虑、抑郁
中文适应病症参考翻译3:
急性躁狂抑郁症
药品信息:

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 详细处方信息以本药内容附件PDF文件(201011100044611.pdf)的“原文Priscribing Information”为准
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部分中文Abilify处方资料(仅供参考)

药物名称
中文药名: 阿立哌唑
英文药名: Abilify (Aripiprazole)

生产厂家
Otsuka America Pharma Inc.
大冢制药公司

适应症
阿立哌唑不仅对精神分裂症的阳性症状有效,而且对精神分裂症的阴性症状、认知功能有改善作用,同时对焦虑、抑郁也有作用。此外,FDA已批准其阿立哌唑(aripiprazole,Abilify)用于治疗包括双极情感障碍相关的躁狂发作和混合发作在内的急性躁狂抑郁症。

不良反应
不良反应轻微, 用本品治疗后,体重变化极微,极少发生锥体外系症状(EPS),且与安慰剂相比,镇静发生率较低(11%对8%)。
另外,用本品治疗的QTc 间期延长的发生率与安慰剂相似。在短期安慰剂对照研究中,EPS的发生率本品组和安慰剂组都为6%,平均体重变化本品组和安慰剂组分别为增加0.7kg和减少0.05kg。
在5500多例病人的研究中确定了本品的安全性和耐受性,其中包括1250多例接受治疗至少1年的病人。在短期(4周和6周)安慰剂对照临床研究中,因不良反应的停药率本品组和安慰剂组无差异,分别为7%和9%。最常见的不良反应(发生率>15%且高于安慰剂)有头痛(32%对安慰剂25%),焦虑(25%对24%)和失眠(24%对19%)。
一项在311例稳定型精神分裂症患者中进行8周的试验结果表明,患者服用奥兰扎平、利培酮或氟哌啶醇后,转用阿立哌唑治疗,可使体重增加显著下降、锥体外系症状改善、催乳素水平降低。
美国北卡罗来纳州立大学的精神病学和药理学教授Jeffrey Lieberman 博士说:“本品代表了一种重要的新的精神分裂症治疗法,临床研究显示本品治疗可使症状获得显著改善,且本品安全性和耐受性良好。”

用药方法
阿立哌唑每日只需服药1次,可根据患者的具体情况早上或者晚上口服,由于该药与食物之间不存在相互作用,可与或不与食物同服。有效剂量范围为10~30mg。推荐的起始剂量和目标剂量为一日10或15mg。
任何疑问,请遵医嘱!

禁忌症
已知(阿立哌唑)过敏的患者禁用。

注意事项
1.应慎用于心血管疾病(心肌梗塞、缺血性心脏病、心脏衰竭或传导异常病史)患者、脑血管疾病患者或诱发低血压的情况(脱水、血容量过低和降压药治疗)。
2. 应慎用于有癫痫病史或癫痫阈值较低的情况(如:阿尔茨海默氏病性痴呆)。
3. 应警告患者小心驾驶汽车。

Abilify
Generic Name: aripiprazole (AR i PIP ra zole)
Brand Names: Abilify, Abilify Discmelt

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What is Abilify?
Abilify (aripiprazole) is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Abilify is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression). It is also used together with other medications to treat major depressive disorder in adults.

Abilify is also used to treat irritability and symptoms of aggression, mood swings, temper tantrums, and self-injury related to autistic disorder in children who are at least 6 years old.

Abilify may also be used for other purposes not listed in this medication guide.

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Important information about Abilify
Abilify is not for use in psychotic conditions that are related to dementia. Abilify may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Stop using Abilify and call your doctor at once if you have the following symptoms: fever with stiff muscles and rapid heart rate; uncontrolled muscle movements; symptoms that come on suddenly such as numbness or weakness, severe headache, and problems with vision, speech, or balance. Abilify can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which can increase some of the side effects of Abilify.

Before you take aripiprazole, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Abilify.

Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Abilify.

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What should I discuss with my healthcare provider before taking Abilify?
Abilify is not for use in psychotic conditions that are related to dementia. Abilify may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

You should not use this medicine if you are allergic to aripiprazole. If you have any of these other conditions, you may need a dose adjustment or special tests to safely take Abilify:
liver or kidney disease;
heart disease, high blood pressure, heart rhythm problems;
a history of heart attack or stroke;
a history of low white blood cell (WBC) counts;
a history of breast cancer;
seizures or epilepsy;
a personal or family history of diabetes; or
trouble swallowing.

The liquid form (oral solution) of this medication may contain up to 15 grams of sugar per dose. Before taking Abilify oral solution, tell your doctor if you have diabetes. The orally disintegrating tablet form of this medication may contain over 3 milligrams of phenylalanine per tablet. Before taking Abilify Discmelt, tell your doctor if you have phenylketonuria.

Abilify may cause you to have high blood sugar (hyperglycemia). Talk to your doctor if you have any signs of hyperglycemia such as increased thirst or urination, excessive hunger, or weakness. If you are diabetic, check your blood sugar levels on a regular basis while you are taking Abilify.

FDA pregnancy category C. It is not known whether Abilify is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Abilify can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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How should I take Abilify?
Take Abilify exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Do not take aripiprazole for longer than 6 weeks unless your doctor has told you to.

Abilify can be taken with or without food.

Measure the liquid form of Abilify with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

To take aripiprazole orally disintegrating tablets (Abilify Discmelt):
Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.
Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.
Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

It is important to take Abilify regularly to get the most benefit.

To be sure this medication is helping your condition, your doctor will need to check your progress on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Store Abilify tablets at room temperature away from moisture and heat.

Abilify oral solution should be stored in the refrigerator and can be used for up to 6 months after opening.

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What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include drowsiness, vomiting, agitation, aggression, confusion, tremors, fast or slow heart rate, seizure (convulsions), trouble breathing, feeling light-headed, or fainting.

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What should I avoid while taking Abilify?
Abilify can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol, which can increase some of the side effects of Abilify.

Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Abilify.

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Abilify side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Abilify and call your doctor at once if you have any of these serious side effects:
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
jerky muscle movements you cannot control;
sudden numbness or weakness, headache, confusion, or problems with vision, speech, or balance;
fever, chills, body aches, flu symptoms;
white patches or sores inside your mouth or on your lips;
increased thirst or urination, loss of appetite, fruity breath odor, drowsiness, dry skin, nausea, and vomiting;
seizure (convulsions);
thoughts of hurting yourself;
feeling like you might pass out;
jaundice (yellowing of your skin or eyes); or
urinating less than usual or not at all.

Less serious Abilify side effects may include:
choking or trouble swallowing;
dizziness, drowsiness, or weakness;
constipation, mild stomach upset;
headache, anxiety;
sleep problems (insomnia); or
weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Abilify?
Before you take Abilify, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Abilify.

Also tell your doctor if you are taking any of the following medicines:
Before taking Abilify, tell your doctor if you are taking any of the following medicines:
a medication to treat high blood pressure or a heart condition;
carbamazepine (Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin);
rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater);
ketoconazole (Nizoral), itraconazole (Sporanox);
quinidine (Cardioquin, Quinaglute); or
fluoxetine (Prozac), fluvoxamine (Luvox), or paroxetine (Paxil).

This list is not complete and there may be other drugs that can interact with Abilify. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about Abilify.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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 详细处方信息以本药内容附件PDF文件(201011100044611.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2015-11-3
附件:




201011100044611.pdf    

 
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