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  药店国别: 德国药房
产地国家: 德国
所属类别: 心血管系统药物->脑及周围血管扩张药物
处方药:处方药
包装规格: 162毫克/胶囊 50胶囊/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
Hexal AG
生产厂家英文名:
Hexal AG
该药品相关信息网址1:
http://www.hexal.de/
原产地英文商品名:
NAFTILONG 200MG PROLONGED RELEASE CAPSULE 162MG/CAP 50CAPS/BOX
原产地英文药品名:
NAFTIDROFURYL
中文参考商品译名:
NAFTILONG 200毫克缓释胶囊 162毫克/胶囊 50胶囊/盒
中文参考药品译名:
萘呋胺
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Peripheral Vascular Disease
英文适应病症2:
Cerebrovascular disease
英文适应病症3:
Alzheimer's disease
英文适应病症4:
Vertigo inner ear disease
临床试验期:
完成
中文适应病症参考翻译1:
外周血管病
中文适应病症参考翻译2:
脑血管病
中文适应病症参考翻译3:
老年痴呆症
中文适应病症参考翻译4:
内耳眩晕症
药品信息:

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 部分中文萘呋胺处方资料(仅供参考)
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萘呋胺(萘呋胺酯)
英文名称:
Naftidrofuryl(Sodipryl,Praxilene,Dusodril,Naftilong)

性状:药用其草酸盐,为白色结晶性粉未,易溶于水。

作用与作用机制:可直接扩张脑血管和外周血管,并增加细胞的氧化能力。因而对细胞缺氧具保护作用。此外具有罂粟碱样的解痉作用,但作用缓慢而持久。

药动学:口服吸收,作用可持续数小时。静注10min起效,维持约1h。

注意事项:可引起恶心、上腹痛。偶有皮疹、肝炎和肝功能衰竭。大剂量可发生惊厥。过量抑制房室传导。静脉给药可能发生心律失常、低血压和惊厥。有房室传导阻滞病人禁用注射给药。有严重心功能不全或传导阻滞及肝、肾功能损害者慎用。

临床应用:用于治疗外周及脑血管病。前者如间歇性跛行、、雷诺病、糖尿病性动脉病变和手足发绀、下肢动脉炎;后者如脑动脉硬化、脑血栓形成、脑栓塞、耳鸣、头颈部损伤及其后遗症等。对老年痴呆症、内耳眩晕症也有一定疗效。

用法计量:口服:100mg次,3次/d。肌注或静注:40mg/次,1-2次/d,连用7-14d,同时口服100mg/次,3次/d。

制剂:胶囊:0.1g。注射剂:0.2g/10ml。
 
Naftilong category:
Human

Active ingredients:
Naftidrofuryl Oxalate

Naftilong companies and manufacturers:
Hexal

Naftilong forms, composition and dosages:
N/A

Indications, usages and classification codes:
D01AE22 - Naftifine

Naftidrofuryl (e.g. NAFTILONG) and liver damage: A 42 year old female patient, who had been hospitalised for cholelithiasis with biliary colic, was, by chance, found to have serious hepatitis, with increased liver enzymes (AST up to 1500 u/l) and bilirubin (total bilirubin 3.42 mg/dl), attributed to the use of naftidrofuryl. After withdrawal of the vasodilator, which had been prescribed for tinnitus since two weeks, the liver enzymes declined. According to the assessment of the attending physicians, obstruction of the bile duct due to the migration of a stone could not have resulted in such an increase in liver enzymes (NETZWERK-report 13.303). NAFTILONG is approved for the treatment of intermittent claudication; its benefit is, however, doubtful for this indication (a-t 2000; 31: 87). Other cases on liver damage are reported in literature. In a 44 year old female patient the use of naftidrofuryl resulted in granulomatous hepatitis with jaundice, dizziness, loss of appetite, darkening in colour of the urine, increased liver enzymes and bilirubin, which was wrongly diagnosed and resulted in an unnecessary cholecystectomy. Within three months after withdrawal from treatment the liver values returned to normal (CHOLONGITAS, E. et al.: Am. J. Gastroenterol. 2003; 98: 1448-50). In a 60 year old female patient with typical complaints of hepatitis, who was also found to have gall stones, naftidrofuryl was considered to be the reason for the liver damage with pronounced centrilobular necrosis (DE CAESTECKER, J.S., HEADING, R.C.: Postgrad. Med. J. 1986; 62: 309-10). Whilst the Rote Liste 2004 mentions only an "isolated case" with liver cell necrosis, the summary of product characteristics states that hepatitis, cholestatic icterus and an increase in liver enzymes can occur in "very rare" cases.

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更新日期: 2012-5-11
附件:


 
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