友情提示：OMNARIS为Sunovion制药公司研发，但OMNARIS是奈科明GmbH.的注册商标。

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 详细处方信息以本药内容附件PDF文件（201242400154731.pdf）的“原文Priscribing Information”为准
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部分中文环索奈德处方资料（仅供参考）

英文药名: Omnaris (Ciclesonide Nasal Spray)

中文药名: 环索奈德鼻喷雾剂

药品名称
【药品名称】环索奈德（Ciclesonide）

规格
鼻喷雾剂，每瓶120喷，每喷含环索奈德100, 200μg; 每瓶100喷，每喷含环索奈德80, 160μg。

作用机制
环索奈德是新一代糖皮质激素，其具有新的释药和分布性质，故能呈现肺靶向抗炎效应。环索奈德是没有活性的母体化合物，对糖皮质激素受体的亲和力低，环索奈德经口吸入后，在肺内酶解为主要代谢物去甲基丙酰-环索奈德（des-CIC），其具有较强的抗炎作用。Des-CIC的抗炎活性与其他用于治疗哮喘的皮质激素药物相似。Des-CIC抑制包括肿瘤坏死因子α、白介素IL-4和白介素IL-5等炎症细胞的增殖和发炎物质的释放。环索奈德在气管炎疾病动物模型试验中，显示出较好的效果。环索奈德在肺内定位活化，因此局部不良反应发生率低，几乎没有全身副作用。环索奈德气雾剂1日1次，每次80～160μg给药，即可明显改善哮喘症状和提高肺功能，用药方便，减少了长期用药发生副反应的风险，耐受性好，临床试验显示控制哮喘安全有效。

适应症
用于治疗季节性和常年性过敏性鼻炎的鼻症状。

用法用量
鼻腔喷入：左手喷右侧鼻孔，右手喷左侧鼻孔，避免直接喷向鼻中隔。
成人6岁以上儿童：开始时每个鼻孔各2喷，早晚各1次。一日最大用量不超过4喷（200μg）。 或遵医嘱！

Omnaris
Generic Name: ciclesonide (nasal) (sik le SON ide)
Brand Names: Omnaris

What is Omnaris?
Omnaris (ciclesonide) is a corticosteroid nasal spray. It prevents the release of substances in the body that cause inflammation.

Omnaris is used to treat nasal symptoms of seasonal allergies and hay fever, such as congestion, sneezing, itching, and runny or stuffy nose. The precise mechanism through which it reduces allergy symptoms is not known.

Omnaris may also be used for other purposes not listed in this medication guide.

Important information about Omnaris
You should not use Omnaris if you are allergic to ciclesonide.
Before using Omnaris, tell your doctor if you are allergic to any drugs, or if you have asthma, glaucoma, tuberculosis or other infection of the lungs, an open sore inside your nose, or a recent nose injury or surgery. Tell your doctor if you are or have been using any other steroid medications: oral, inhaled, or injected.

Omnaris comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Call your doctor if your nasal allergy symptoms get worse, or if they do not improve after using this medication for 2 weeks. It may take up to 5 weeks for your symptoms to improve if you use this medicine only during certain times of the year.
If you stopped using another steroid medication when you started using Omnaris, you may have steroid withdrawal symptoms. These symptoms include joint or muscle pain, depression, and weakness. Do not stop using any steroid medication without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Although it is not likely that your body will absorb enough Omnaris to cause serious side effects, tell your doctor if you have any steroid-related symptoms such as irregular menstrual periods, acne, increased hair growth, swelling, rapid weight gain, roundness of the face, increased sweating, or unusual thoughts or behavior.

Call your doctor as soon as possible if you have sores or white patches inside or around your nostrils, or if you have any vision problems, such as tunnel vision.
Less serious Omnaris side effects are more likely, and you may have none at all. Talk to your doctor about any side effect that seems unusual or is especially bothersome.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Before using Omnaris
You should not use Omnaris if you are allergic to ciclesonide.
Before using Omnaris, tell your doctor if you are allergic to any drugs, or if you have:
•asthma;
•glaucoma;
•tuberculosis or other infection of the lungs;
•a sore inside your nose that has not yet healed;
•a recent nose injury or surgery; or
•if you are or have been using an oral, inhaled, or injected steroid such as cortisone, methylprednisolone, prednisone, beclomethasone (Beclovent), flunisolide (AeroBid), fluticasone (Advair, Flovent), triamcinolone (Azmacort), and others.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use Omnaris.

FDA pregnancy category C. Omnaris may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Omnaris passes into breast milk or if it could harm a nursing baby. Do not use Omnaris without telling your doctor if you are breast-feeding a baby.

Long-term use of steroid medication can slow a child's growth. Tell your doctor if the child using this medication is not growing or gaining weight properly.

How should I use Omnaris?
Use Omnaris exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Omnaris nasal spray is most often used once daily as 2 sprays into each nostril. Follow your doctor's instructions.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

If needed, blow your nose to clear your nostrils just before using Omnaris.

Shake the Omnaris nasal spray bottle gently before each use.
If you are using the nasal spray bottle for the first time, you must prime the bottle by pumping 8 sprays into the air, away from your face. If you have not used the bottle for longer than 4 days in a row, prime the pump with 1 priming spray.

Call your doctor if your nasal allergy symptoms get worse, or if they do not improve after using this medication for 2 weeks. It may take up to 5 weeks for your symptoms to improve if you use this medicine only during certain times of the year.

If you stopped using another steroid medication when you started using Omnaris, you may have steroid withdrawal symptoms. These symptoms include joint or muscle pain, depression, and weakness. Do not stop using any steroid medication without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Store Omnaris at room temperature with the bottle upright, away from moisture and heat. Do not allow the medicine to freeze. Keep the spray bottle clean and dry.

The Omnaris bottle contains enough medicine for 120 sprays. Throw the bottle away after 120 sprays, or 4 months after removing the bottle from the foil pouch, whichever comes first.

What happens if I miss a dose?
Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Omnaris nasal spray is not expected to produce life-threatening symptoms.

What should I avoid while using Omnaris?
Avoid getting this medication in your eyes. If this does happen, rinse thoroughly with water.
Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Omnaris side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Although it is not likely that your body will absorb enough of this medication to cause serious side effects, tell your doctor if you have any of these steroid-related symptoms:
•irregular menstrual periods;
•acne or increased hair growth;
•swelling, rapid weight gain, roundness of the face;
•increased sweating; or
•depression, anxiety, unusual thoughts or behavior.

Call your doctor as soon as possible if you have sores or white patches inside or around your nostrils, or if you have any vision problems, such as tunnel vision.
Less serious side effects may include:
•headache;
•nosebleed;
•stuffy nose, sore throat; or
•ear pain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Omnaris?
Before using this medication, tell your doctor if you are also taking ketoconazole (Nizoral).

There may be other drugs that can interact with Omnaris. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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 详细处方信息以本药内容附件PDF文件（201242400154731.pdf）的“原文Priscribing Information”为准
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