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当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->头痛药物
处方药:处方药
包装规格: 40毫克/片 6片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
爱尔兰辉瑞制药
生产厂家英文名:
PFIZER IRELAND
该药品相关信息网址1:
http://www.drugs.com/relpax.html
该药品相关信息网址2:
http://www.rxlist.com/relpax-drug.htm
该药品相关信息网址3:
http://www.pdrhealth.com/drugs/relpax
原产地英文商品名:
RELPAX 40MG/TAB 6TABS/BOX
原产地英文药品名:
ELETRIPTAN HYDROBROMIDE
中文参考商品译名:
RELPAX 40毫克/片 6片/盒
中文参考药品译名:
氢溴酸依来曲普坦
中文参考化合物名称:
3-[[(R)-1-甲基-2-吡咯烷基]甲基]-5-[2-(苯磺酰基)乙基]吲哚单氢溴酸盐
原产地国家批准上市年份:
2002/12/26
英文适应病症1:
Migraine
临床试验期:
完成
中文适应病症参考翻译1:
偏头痛
药品信息:

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 详细处方信息以本药内容附件PDF文件(201221921155016.pdf)的“原文Priscribing Information”为准
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部分中文氢溴酸依来曲普坦处方资料(仅供参考)

通用名称:eletriptan hydrobromide,氢溴酸依来曲普坦

化学名称:3-[[(R)-1-甲基-2-吡咯烷基]甲基]-5-[2-(苯磺酰基)乙基]吲哚单氢溴酸盐

药理作用:
    本品为选择性5-HT1B/1D受体激动剂,与5HT1B,5HT1F受体有高度亲和力,与5HT1A,5HT1E,5HT2B和5HT7,的亲和力次之,与5HT2A,5HT2C,5HT3,5HT4,5HT5A和5HT6受体几乎无亲和力。另外,本品与肾上腺素能α1,α2或β受体,多巴胺能D1或D2受体,毒蕈碱能受体或阿片受体无明显亲和力或药理活性。
    5HT受体拮抗剂治疗偏头痛的2种药理机制假设为:一是活化颅内血管(包括动静脉吻合)上的5HT1受体引起血管收缩,从而缓解偏头痛症状;另一种是活化三叉神经系统感觉神经末梢上5HT1受体而抑制炎症神经肽原(pro-inflammatory neuropeptide)类物质的释放。
    在动物实验中发现本品可减少颈动脉血流量,在高剂量时引起动脉血压轻微升高,对备注的作用主要选择性作用于颈动脉床,降低冠状动脉参数;对大鼠进行的实验发现本品可抑制三叉神经活性。

药动学:口服吸收好,达峰时间约为1.5h,生物利用度约为50%,与高脂食物合用时AUC和Cmax增加20%~30%。静注后分布体积约为138L,与血浆蛋白结合率约为85%。主要由CYP3A4酶代谢,目前唯一可知的活性代谢物为N-脱甲基依来曲普坦,其t1/2为4h,口服后平均肾清除率约为3.9L.h-1,但非肾清除约占总清除的90%。

适应证:偏头痛急性发作。

用法与用量:宜个体化给药。推荐剂量为单次40mg,必要时可在首次剂量2h后重复1次剂量,但最大日剂量不超过80mg。

药物不良反应:通常耐受性好,多数不良反应比较轻微,且为一过性,其中最常见的不良反应有虚弱、恶心、眩晕、嗜睡,均与剂量相关。其他还有感觉异常、潮红、胸痛、腹部不适、口干、消化不良和咽痛等。本品严重的不良反应为心脏疾病,对有易发心脏病因素者甚至可引起致命危险,但发生率很低,如冠状动脉血管痉挛、一过性心肌局部缺血、心肌梗死、室性心动过速、室性纤颤等。

Relpax
Generic Name:
Eletriptan

What is Relpax?
Relpax is used to treat migraine attacks in adults. It shortens the duration of the headache but will not prevent attacks.

What is the most important information I should know about Relpax?
Relpax should only be used during a migraine attack. Do not attempt to prevent migraines with this drug, and do not use it for other types of headaches.

In rare cases, medications similar to Relpax have caused heart attack, stroke, and certain types of ischemia (restricted blood flow to an area). Call your doctor immediately if you experience chest pains, shortness of breath, sudden numbness or weakness on one side of the body, trouble speaking or seeing, loss of balance, bloody diarrhea, or stomach pain.

If you are at risk for stroke or heart disease, your doctor may perform tests to be sure it is safe for you to take this medication. Relpax can also increase blood pressure, especially in people with kidney problems and the elderly. Your doctor will monitor you closely to make sure your blood pressure stays at a safe level.

Who should not take Relpax?
Do not use Relpax if you are allergic to any of its ingredients, or if you have a history of heart disease, stroke, uncontrolled high blood pressure, or severe liver impairment.

Do not take Relpax if you have taken any of the following medications within the last 72 hours: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, or nelfinavir.

What should I tell my doctor before I take the first dose of Relpax?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with this drug. Also, talk to your doctor about your complete medical history, especially if you have a history of kidney or liver problems, high blood pressure, stroke or blood vessel disease, heart problems, or if you have risk factors for heart disease (such as high cholesterol, diabetes, smoking, obesity, or a family history of heart disease or stroke). Also tell your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Adults: The usual dose to treat an attack is one tablet containing either 20 milligrams (mg) or 40 mg; each dose should be separated by at least 2 hours. Do not take more than 80 mg of Relpax in a 24-hour period.

How should I take Relpax?
Take Relpax as soon as you feel a migraine starting, exactly as prescribed by your doctor. If your headache comes back after your first dose, you may take a second dose 2 or more hours after the first dose. However, if you do not experience any pain relief after the first dose, do not take a second dose without checking with your doctor.

What should I avoid while taking Relpax?
Since Relpax can make you drowsy or dizzy, do not participate in activities that require full alertness until you know how this drug affects you.

What are possible food and drug interactions associated with Relpax?
If Relpax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Never take Relpax within 24 hours of using another migraine or headache drug, including triptans and ergotamines such as the following: almotriptan, dihydroergotamine, ergotamine, frovatriptan, methysergide, naratriptan, rizatriptan, sumatriptan, and zolmitriptan.

In addition, do not take Relpax within 72 hours of the following: clarithromycin, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, and troleandomycin.

What are the possible side effects of Relpax?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: chest or throat tightness or pressure, dizziness, dry mouth, headache, nausea, sleepiness, tingling, weakness

Can I receive Relpax if I am pregnant or breastfeeding?
The effects of Relpax during pregnancy are unkown. If you are pregnant or plan to become pregnant, inform your doctor immediately. Relpax is excreted in breast milk; talk with your doctor if you plan on breastfeeding.

What should I do if I miss a dose of Relpax?
Relpax is not intended for regular use and should be taken only to relieve an acute migraine attack.

How should I store Relpax?
Store at room temperature.

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 详细处方信息以本药内容附件PDF文件(201221921155016.pdf)的“原文Priscribing Information”为准
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更新日期: 2014-08-18
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