您好,欢迎光临世界标品! 登录 注册(订药物标准品请用邮件联系我们)

中国医药研发对照标品提供商
Non-clinical Research-used
Medicine Sample Provider

当前本网站药物产品种数共 8473 处方药 8099 非处方药 268 保健品/医疗用具 106

世界标品医药目录搜索(中英文):
世界各国官方药品目录搜索(英文):
世界标品医药知识搜索(中英文):

联系方式
国内客服电话:
国际免费电话:


QQ客服1:1793093587
QQ客服2:1586083059
QQ客服3:2786706041
QQ客服6:2992753224
QQ客服7:2394834588

咨询邮箱:
scimed.shanghai@shijiebiaopin.com
info@shijiebiaopin.com
pharmacy.shijiebiaopin1@gmail.com
pharmacy.shijiebiaopin2@gmail.com

  药店国别: 日本药房
产地国家: 日本
所属类别: 心血管系统药物->抗心绞痛药物
处方药:处方药
包装规格: 81毫克/片 100片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
Lion
生产厂家英文名:
Lion
该药品相关信息网址1:
http://www.genome.jp/kusuri/japic_med/show/00057436
该药品相关信息网址2:
http://www.medbroadcast.com/drug_info_details.asp?brand_name_id=1499
该药品相关信息网址3:
http://www.drugs.com/mtm/bufferin.html
原产地英文商品名:
Bufferin(バファリン) 81mg/tab 100tabs/box
原产地英文药品名:
Aspirin/Aluminum Glycinate/Magnesium Carbonate
中文参考商品译名:
巴非林(バファリン) 81毫克/片 100片/盒
中文参考药品译名:
阿司匹林/甘羟铝/碳酸镁
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Inhibiting platelet adhesion and aggregation
英文适应病症2:
Unstable angina
英文适应病症3:
Acute myocardial infarction
英文适应病症4:
Ischemic cerebrovascular disorders
临床试验期:
完成
中文适应病症参考翻译1:
抑制血小板粘附和聚集
中文适应病症参考翻译2:
不稳定心绞痛
中文适应病症参考翻译3:
急性心肌梗死
中文适应病症参考翻译4:
局部缺血性脑血管障碍
药品信息:

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(201221423470929.PDF,201221423470426.PDF)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文沃丽汀处方资料(仅供参考)

产品概述  
阿司匹林抗血小板聚集的作用在临床上得到广泛应用,在预防和治疗心肌梗塞和脑梗塞方面有较好的疗效,是心血管疾病二级预防中的首选药,长期使用可降低发病率和死亡率。
但是长期服用阿司匹林会导致胃肠道反应,胃肠道出血或溃疡。铝镁匹林片Ⅱ是阿司匹林复方制剂,每片含阿司匹林81mg、甘羟铝11mg、重质碳酸镁22mg,甘羟铝和重质碳酸镁为酸制剂,保护胃粘膜,可减轻阿司匹林的胃肠不良反应。

产品特点
> 胃保护  
铝镁匹林片区别于普通阿司匹林片的最大特点和优势在于:胃部不良反应发生率的降低。
阿司匹林通过不可逆的抑制花生四烯酸的合成,阻断血栓素A2合成,从而达到抗血栓的效果。但由于其游离羧基的存在,使胃部的酸度增加而造成胃粘膜不同程度的刺激性损伤,会引起胃膜轻度糜烂而形成溃疡、出血、穿孔及十二指肠出血等症。
铝镁匹林片含有甘羟铝,可中和胃酸,改善胃酸增多、上腹部疼痛等临床症状,并有收敛、止血等作用;重质碳酸镁为抗酸药,可减低阿司匹林对胃的不良刺激,显著降低胃粘膜糜烂和溃疡的发生率,从而起到对胃的保护作用。
> 安全性好,更适合长期服用
临床研究表明,铝镁匹林片用药24周,疗效稳定,且与试验相关的不良事件发生率显著低于服用普通阿司匹林片。
本品进入胃部后,甘羟铝和重质碳酸镁能够形成碱性环境,显著降低胃部酸度,避免了胃粘膜受到刺激,既达到了预期疗效,又避免了普通阿司匹林引起的胃肠道反应等不良症状,因而从安全性角度分析,铝镁匹林片更适合长期服用。
> 吸收度强  
药物吸收速度受药片的溶解速度、胃粘膜表面的pH值、胃排空时间等多种因素的影响。铝镁匹林片创新性的将阿司匹林与碱性药物(甘羟铝和重质碳酸镁)并用,达到全新的效果,碱性药物可使胃排空加快,促使药物迅速进入主要吸收部位——小肠。
长期服用安全性依据  
本复方在日本自2000年上市,商品名为BUFFERIN 81MG(巴非林81mg),由日本LION公司生产,使用至今并无与铝蓄积毒性相关的不良反应报道。

------------------------------------------------

    该药物于2001年在日本由LION公司研发上市,商品名为BUFFERIN。其中小剂量规格作为抗血小板剂推向市场。

    主要成分为阿司匹林、甘羟铝和重质碳酸镁(铝镁匹林)。该产品主要适应症为需要使用阿司匹林抑制血小板粘附和聚集,但患者不能耐受阿司匹林的胃肠道反应时,包括不稳定心绞痛、急性心肌梗死、局部缺血性脑血管障碍等。

    阿司匹林在心脑血管领域作用巨大
    阿司匹林又名醋柳酸、乙酰水杨酸,其发展已有100多年的历史,在全世界广泛的医疗实践中,逐渐发现它不仅是解热镇痛药,而且还可以治疗许多疾病,对于某些病还是特效药。阿司匹林治疗心血管病,已成为最新的有效疗法。医学界普遍认为它具有降低血液凝聚的能力,有抗血栓和溶化血栓的作用。
    对于有心脏病或中风史的病人,阿司匹林可以使心肌梗死继发残废或再次梗死的危险率降低约25%,可以使不稳定型心绞痛的危险性发作降低35%以上,可以使暂短性缺血性发作的病人,出现中风或导致死亡的情况减少25%。

    铝镁匹林或将成阿司匹林最佳替代药物
    尽管阿司匹林在抗血小板聚集等多个治疗领域发挥着重要的作用,但其对胃粘膜刺激较大,胃肠道副作用发生率较高,不适合长期服用,制约了在临床的使用,如何在发挥阿司匹林的治疗作用的同时,又能减少其对胃肠道的刺激成了阿司匹林相关创新药物研发的重点,铝镁匹林主要优点是一方面可以减低阿司匹林对胃的不良刺激,显著降低胃粘膜糜烂和溃疡的发生率;另一方面还可增加其吸收度,碱性药物可使胃排空加速,从而使阿司匹林迅速进入主要吸收部位——小肠。

    在中国医学科学院以及卫生部心血管药物临床研究重点实验室进行了对铝镁匹林片(Ⅱ)单剂量和多剂量人体药动力学研究实验,中国心脑血管领域最权威专家胡大一、李一石等都参与了本次实验,结果显示,本试验表明铝镁匹林片(Ⅱ)与阿司匹林一样有效,都能明显降低血小板聚集率,使尿11-DH-H-TXB2水平下降,两组间的抗血小板聚集作用无明显差异。文献报道的阿司匹林抗血小板聚集作用因试验条件不同结果也不尽相同,本试验中阿司匹林的抗血小板聚集作用与既往某些文献报道有相似性,文献报道用药前后血小板最大聚集率下降10%~40%,本试验用药前后血小板最大聚集率下降20%左右。试验中与试验药物相关的不良事件发生率铝镁匹林片(Ⅱ)组低于阿司匹林组,两组间比较有显著的差异,主要表现在消化系统不良事件发生率铝镁匹林片(Ⅱ)组明显低于阿司匹林组。证实铝镁匹林片(Ⅱ)的复方设计达到预期的减低胃肠不良反应的效果,且复方中的其他药物未对阿司匹林的抗血小板聚集作用产生明显影响。

    根据中国医学科学院——中国协和医科大学阜外心血管病医院,卫生部心血管药物临床研究重点实验室所做的“铝镁匹林片(Ⅱ)在健康人体的药动学和药效学研究”实验显示,连续口服镁铝匹林,吸收迅速,tmax为30~40min,该药代谢遵循一级动力学消除,t1/2为17•4~29•8min。阿司匹林在吸收过程中为水杨酸速度快,在阿司匹林达峰10min后,阿司匹林代谢为水杨酸,血中水杨酸tmax为33•3~53•3min,t1/2为168•2~209•6min。连续口服81mg、162mg、324mg铝镁匹林片(Ⅱ),血浆中阿司匹林及水杨酸血药浓度随给药剂量增加而增加,蓄积系数Rac均为1左右,表明该药在体内无蓄积。该研究与文献报道的阿司匹林片剂药动学结果基本一致。

Brand Name
Bufferin

Common Name
acetylsalicylic acid (ASA)

DIN (Drug Identification Number)
01990667  BUFFERIN 325MG TABLET
01990691  BUFFERIN EXTRA -STRENGTH 500MG TABLET

How does this medication work? What will it do for me?
Acetylsalicylic acid (ASA) belongs to the group of medications called analgesics (pain relievers), antipyretics (fever reducers), anti-inflammatories (inflammation reducers), and platelet aggregation inhibitors (anticlotting agents). It works by interfering with the production of compounds in the body that cause pain, fever, inflammation, and blood clots.

Acetylsalicylic acid (ASA) is used to relieve pain, fever, and inflammation in various conditions such as lower back and neck pain, the flu, common cold, burns, menstrual pain, headache, migraines, osteoarthritis, rheumatoid arthritis, sprains and strains, nerve pain, toothache, muscle pain, bursitis (inflammation of a bursa, a fluid-filled sac located around joints and near the bones), and following surgical and dental procedures. ASA is also used for rheumatic fever in combination with other medications. In these situations, ASA is used on an as-needed basis.

Because of the antiplatelet (anticlotting) properties of ASA, it may be used under the supervision of your doctor to:
prevent a first nonfatal heart attack in people who are at increased risk of having a heart attack as determined by their doctor (factors that increase your risk of heart attack include: smoking, high blood pressure, high cholesterol, inactive lifestyle, stress, and being overweight)
prevent a second heart attack or stroke
reduce the risk of "mini-stroke" or transient ischemic attack (TIA)
reduce the clotting properties of platelets for people who have had carotid artery surgery to prevent the recurrence of TIA and for people receiving hemodialysis through a silicone rubber access
prevent blood clots for people who have had a total hip replacement

ASA can also be used during a heart attack to reduce the risk of dying from the heart attack.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?
The recommended dose of ASA for adults varies widely according to the particular condition being treated.

Adult dosage:
To treat pain or fever in adults, the recommended dose is 325 mg to 650 mg every 4 to 6 hours as needed. The maximum daily dose is 4,000 mg, unless otherwise directed by your doctor.

For adults with conditions caused by inflammation such as rheumatoid arthritis, the usual dose is 975 mg 4 to 6 times daily on a regular basis. Sometimes, higher doses may be used.

To treat migraine headache pain, the recommended adult dose is 1,000 mg at the onset of pain or symptoms.

To prevent a first nonfatal heart attack, TIA, a second heart attack, or a second stroke, the usual dose for adults is 80 mg to 325 mg once daily, depending on your doctor's instructions.

During a heart attack, the recommended ASA dose is 160 mg to 162.5 mg chewed or crushed. As soon as you suspect you are having a heart attack, call an ambulance and take the recommended ASA dose, providing you have no allergies or other conditions or factors that would indicate ASA is not right for you.

To prevent blood clots after total hip replacement surgery, the recommended dose is 650 mg twice a day started one day before surgery and continued for 14 days after surgery unless otherwise directed by your doctor.

For rheumatic fever, the usual dose of ASA is 80 mg per kilogram of body weight per day in divided doses.

Children's dosage:
This medication is not recommended to be used by children, teenagers, or young adults to treat fever (see the section, "Are there any other precautions or warnings for this medication?"). However, if recommended by a doctor in other circumstances such as to treat pain, the recommended dose is 10 mg to 15 mg per kilogram of body weight every 6 hours as needed to a maximum of 2,400 mg per day (ask your doctor or pharmacist to give you the correct dose if you are unsure).

When used as an anti-inflammatory, the recommended dose is 60 mg to 125 mg per kilogram of body weight daily in 4 to 6 divided doses.

Because ASA can cause stomach irritation and upset, specially coated tablets called enteric-coated are recommended when taking ASA for long periods of time. This special coating prevents the tablet from dissolving until it has passed the stomach and moved into the small intestine. This coating also means that it will take longer for the medication to take effect, so do not use enteric-coated tablets when fast relief is required. ASA should also be taken with food to prevent stomach upset. Enteric-coated medications can be taken without food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way you are taking the medication without talking to your doctor.

It is important to use this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from moisture, and keep it out of the reach of children.

This medication is available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms listed here. The forms available for the specific brand you have searched are listed under "What form(s) does this medication come in?"

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?
This medication is available as 325 mg and 500 mg tablets.

Who should NOT take this medication?
Do not take this medication if you:
are allergic to ASA or any ingredients of the medication
are in your last trimester of pregnancy
are prone to bleeding
are using methotrexate at doses of 15 mg or more per week
have an active peptic ulcer
have had a severe allergic or asthmatic reaction caused by salicylates, ASA, or nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., diclofenac, ibuprofen, indomethacin, naproxen)

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(201221423470929.PDF,201221423470426.PDF)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2013-03-26
附件:
201221423470929.PDF    

201221423470426.PDF    

 
调控比例: 100%
订购表单下载
Copyrights © 2010,2011,2012 www.ShiJieBiaoPin.com, Inc., All rights Reserved www.ShiJieBiaoPin.com, Inc.
客服工作时间:太平洋时间18:00-24:00
国内客服电话:     国际免费电话:
友情提示:以上电话为免费电话,无需您承担任何费用,世界标品提供中文客服,请您放心拨打!
电子邮箱:info.shijiebiaopin.com@gmail.com, info@shijiebiaopin.com