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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->镇痛药
处方药:处方药
包装规格: 800毫克/片 100片/瓶
计价单位:
   
该药品相关信息网址1:
http://www.motrin.com/
该药品相关信息网址2:
http://www.drugs.com/motrin.html
该药品相关信息网址3:
http://www.rxlist.com/ibuprofen-drug.htm
原产地英文商品名:
IBUPROFEN(MOTRIN GENERIC) 800MG/TAB 100TABS/BOTTLE
原产地英文药品名:
IBUPROFEN
中文参考商品译名:
布洛芬(MOTRIN仿制药) 800毫克/片 100片/瓶
中文参考药品译名:
布洛芬
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Arthritis
英文适应病症2:
Pain
英文适应病症3:
Gout
英文适应病症4:
Dysmenorrhea
临床试验期:
完成
中文适应病症参考翻译1:
关节炎
中文适应病症参考翻译2:
疼痛
中文适应病症参考翻译3:
痛风
中文适应病症参考翻译4:
痛经
药品信息:

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(201161522263621.pdf)的“原文Priscribing Information”为准
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部分中文匹伐他汀处方资料(仅供参考)

【概论】
通用名称:布洛芬   
英文名称:Ibuprofen   
中文别名:拔怒风、异丁苯丙酸、异丁洛芬   
英文别名:Algofen、Amersol、Andran、Apsifen、Brufen、Ebufac、Emodin、Inflam、Motrin、Rurana

【药理】
药效学   
    本品的镇痛、消炎作用机制尚未完全阐明,可能作用于炎症组织局部,通过抑制前列腺素或其他递质的合成而起作用,由于白细胞活动及溶酶体酶释放被抑制,使组织局部的痛觉冲动减少,痛觉受体的敏感性降低。治疗痛风是通过消炎、镇痛、并不能纠正高尿酸血症。治疗痛经的作用机理可能是前列腺素合成受到抑制使子宫内压力下降、宫缩减少。   
药动学   
    口服易吸收,与食物同服时吸收减慢,但吸收量不减少。与含铝和镁的抗酸药同服不影响吸收。血浆蛋白结合率为99%。服药后1.2~2.1小时血药浓度达峰值, 用量200mg,血药浓度为22~27μg/ml, 用量400mg时为23~45μg/ml, 用量600mg时为43~57μg/ml。一次给药后半衰期一般为1.8~2小时。本品在肝内代谢, 60~90%经肾由尿排出,100%于24小时内排出,其中约1%为原形物,一部分随粪便排出。

【适应症】
1. 关节炎:该药可缓解急慢性类风湿性关节炎、骨关节炎、强直性脊柱炎、软组织风湿的发作,并可长期服用。用布洛芬缓释胶囊治疗风湿性关节炎与芬必得治疗该疾病进行了对照,结果显示:布洛芬缓释胶囊与芬必得治疗类风湿性关节炎的疗效相似。   
2. 疼痛:用于缓解轻度或中度疼痛。如,牙科、产科、矫形手术后的疼痛以及软组织运动损伤后的肌肉、骨骼引起的疼痛。也可缓解头痛、滑囊炎、肌腱炎等非类风湿性关节炎性疼痛。   
3. 痛风:该药对痛风具有镇痛和抗炎作用。   
4. 痛经,对原发性痛经及宫内异物(如宫内节育器)引起的继发性痛经,除缓解疼痛外,还能减少月经失血量。 5. 退热:主要用于一般感冒或流行性感冒引起的高热。秦玉生等在布洛芬栓对发热患儿的解热实验中,60例发热儿童在常规退热的基础上应用小儿布洛芬栓,而58例对照组的儿童仅给以常规退热。结果治疗组显效率为35%,总有效率为91.7%,均高于对照组的5.2%和75.9%,显示小儿布洛芬栓在治疗小儿发热方面具有满意疗效。

【用法用量】
1.成人常用量口服。①抗风湿,一次 0.4—0.8g,一日 3—4次,类风湿性关节炎比骨关节炎用量要大些;②轻或中等疼痛及痛经的止痛,一次 0.2—0.4,每 4—6小时一次。成人用药最大限量一般为每天 2.4g(国外有人用至每天 3.6g)。   
2.小儿常用量口服。每次按体重 5—10mg/kg,一日 3次。   
[制剂与规格]布洛芬片(1)0.1g(2)0.2g   
口服,一日0.6g,分3次饭时服.

【禁用慎用】
(1)交叉过敏:对阿司匹林或其他非甾体类消炎药过敏者对本品可有交叉过敏反应。对阿司匹林过敏的哮喘患者,本品也可引起支气管痉挛。   
(2)用于晚期妊娠妇女可使孕期延长,引起难产及产程延长。孕妇及哺乳期妇女不宜用。   
(3)对阿司匹林或其他非甾体类消炎药有严重过敏反应者禁用。有下列情况者应慎用:①哮喘,用药后可加重;②心功能不全、高血压,用药后可致水潴留、水肿;③血友病或其他出血性疾病(包括凝血障碍及血小板功能异常),用药后出血时间延长,出血倾向加重;④有消化道溃疡病史者,应用本品时易出现胃肠道副作用,包括产生新的溃疡;⑤肾功能不全者用药后肾脏不良反应增多,甚至导致肾功能衰竭。   
    有潜在的消化性溃疡患者应慎用此药。周身性红斑狼疮患者发生过敏反应的危险大大高于类风湿病患者。

【给药说明】
①有些应用阿司匹林引起胃肠道不良反应的患者,可改用本品,但应密切注意不良反应、形成溃疡或发生出血等;②治疗类风湿性关节炎,本品还可与金制剂或皮质激素同用,症状缓解可更明显;
③用药期间如出现胃肠出血,肝、肾功能损害,视力障碍、血象异常以及过敏反应等情况,应立即停药。   
    长期用药时应定期检查血象及肝、肾功能。

【不良反应】
①过敏性皮疹、胃烧灼感或消化不良、胃痛或不适感(胃肠道刺激或溃疡形成)、恶心、呕吐、头晕等,发生率可达 3—9%;
②皮肤瘙痒、耳鸣、下肢水肿或体重骤增、腹胀、便秘、腹泻、食欲减退或消失、头痛、精神紧张等,发生率可达 1—3%;
③血便或柏油样便(胃肠道出血)、过敏性肾炎、膀胱炎、肾病综合征、肾乳头坏死或肾功能衰竭、荨麻疹、支气管痉挛、视力模溯、耳聋、肝功能减退、精神恍惚、嗜睡、失眠等很少见,发生率<1%。 个别病例有皮疹,消化不良,胃肠道溃疡及出血,转氨酶升高。   
    最常见的不良反应是胃肠系统,其发生率高达30%,从腹部不适到严重的出血或使消化溃疡复发。中枢神经系统的不良反应极为常见,但较轻,如头痛或头晕。长期大剂量使用时可发生血液病或肾损伤。肝毒性作用十分轻微。过敏反应不常见,可能出现伴有皮疹的发热、腹痛、头痛、恶心和呕吐,肝脏损害甚至出现脑膜炎症状。应用此药时常见盐及体液潴留,从而引起充血性心衰,但很罕见。   
    此药对易感者能引起哮喘发作。它能引起哮喘患者的支气管收缩。   
    中枢神经系统症状较常见,其中头痛、眩晕、耳鸣和失眠的发生率最高,但很少出现抑郁或其他精神症状。有些中枢神经系统症状如假性脑膜炎、脑膜炎、嗜睡及易激惹,可能是由于过敏反应。   
    此药具有强的胃毒性作用,各种胃肠道的刺激症状(如恶心、呕吐、厌食、消化不良、烧心、腹痛、隐血、呕血和溃疡发作而致大出血)的发生率极高,一般在30~40%左右。使用布洛芬栓剂后可发生疼痛和刺激直肠粘膜。布洛芬在体内、体外均抑制血小板聚集,剂量低于1g时,血凝试验无明显变化;但大剂量下可使出血时间延长,但不如阿司匹林。它还可诱致不同程度的各种血液病,如粒细胞缺乏症、粒细胞减少症、血小板缺乏症及致命的全细胞减少症。有报告发生不易恢复的白细胞再生不良伴骨髓浆细胞增多及血清中有依赖IgG抗体的补体。个别病例可因胃肠道隐血而导致贫血。   
    它使血浆中尿酸浓度升高,甚至有时达到有病理学意义。   
    过敏性皮肤反应不常见,多为短暂性荨麻疹、紫癜性或红斑性改变,常伴有瘙痒。也有报告发生脱发者。

【相互作用】
(1)饮酒或与其他非甾体类消炎药同用时增加胃肠道副作用,并有致溃疡的危险。长期与对乙酰氨基酚同用时可增加对肾脏的毒副作用。   
(2)与阿司匹林或其他水杨酸类药物同用时,药效不增强,而胃肠道不良反应及出血倾向发生率增高。   
(3)与肝素、双香豆素等抗凝药及血小板聚集抑制药同用时有增加出血的危险。   
(4)与呋塞米同用时,后者的排钠和降压作用减弱。   
(5)与维拉帕米、硝苯啶同用时,本品的血药浓度增高。   
(6)本品可增高地高辛的血浓度,同用时须注意调整地高辛的剂量。   
(7)本品可增强抗糖尿病药(包括口服降糖药)的作用。   
(8)本品与抗高血压药同用时可影响后者的降压效果。   
(9)丙磺舒可降低本品的排泄,增加血药浓度,从而增加毒性,故同用时宜减少本品剂量。   
(10)本品可降低甲氨蝶呤的排泄,增高其血浓度,甚至可达中毒水平,故本品不应与中或大剂量甲氨蝶呤疗法同用。   
    它使各种降压药的降压作用减低,它抑制苯妥英的降解。

【同类药物】
  萘普生(naproxen)、非诺洛芬(fenoprofen)、酮洛芬(ketoprofen)、氟比洛芬(flurbiprofen)、奥沙普嗪(丙恶嗪,oxaprozin)以上药物均为丙酸类药物,药效相似。

GENERIC NAME: ibuprofen

BRAND NAME: Advil, Children's Advil/Motrin, Medipren, Motrin, Nuprin, PediaCare Fever etc.

DRUG CLASS AND MECHANISM: Ibuprofen belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). Other members of this class include aspirin, naproxen (Aleve), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. Pain, fever, and inflammation are promoted by the release in the body of chemicals called prostaglandins. Ibuprofen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved ibuprofen in 1974.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Tablets of 200, 400, 600, and 800 mg; Chewable tablets of 50 and 100 mg; Capsules of 200 mg; Suspension of 100 mg/2.5 ml and 100 mg/5 ml; Oral drops of 40 mg/ml.

STORAGE: Ibuprofen should be stored at room temperature, between 15-30°C (59-86°F).

PRESCRIBED FOR: Ibuprofen is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases.

DOSING: For minor aches, mild to moderate pain, menstrual cramps, and fever, the usual adult dose is 200 or 400 mg every 4 to 6 hours.

Arthritis is treated with 300 to 800 mg 3 or 4 times daily.

When under the care of a physician, the maximum dose of ibuprofen is 3.2 g daily. Otherwise, the maximum dose is 1.2 g daily. Individuals should not use ibuprofen for more than 10 days for the treatment of pain or more than 3 days for the treatment of a fever unless directed by a physician.

Children 6 months to 12 years of age usually are given 5-10 mg/kg of ibuprofen every 6-8 hours for the treatment of fever and pain. The maximum dose is 40 mg/kg daily.

Juvenile arthritis is treated with 20 to 40 mg/kg/day in 3-4 divided doses.

Ibuprofen should be taken with meals to prevent stomach upset.

DRUG INTERACTIONS: Ibuprofen is associated with several suspected or probable interactions that can affect the action of other drugs. Ibuprofen may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. Ibuprofen may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure. When ibuprofen is used in combination with aminoglycosides [for example, gentamicin (Garamycin)] the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycosides from the body is reduced. This may lead to aminoglycoside-related side effects. Individuals taking oral blood thinners or anticoagulants [for example, warfarin (Coumadin)] should avoid ibuprofen because ibuprofen also thins the blood, and excessive blood thinning may lead to bleeding.

PREGNANCY: There are no adequate studies of ibuprofen in pregnant women. Therefore, ibuprofen is not recommended during pregnancy. Ibuprofen should be avoided in late pregnancy due to the risk of premature closure of the ductus arteriosus in the fetal heart

NURSING MOTHERS: Ibuprofen is not excreted in breast milk. Use of ibuprofen while breastfeeding, poses little risk to the infant.

SIDE EFFECTS: The most common side effects from ibuprofen are rash, ringing in the ears, headaches, dizziness, drowsiness, abdominal pain, nausea, diarrhea, constipation and heartburn. NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Ibuprofen may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration can occur without abdominal pain, and black, tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) due to bleeding may be the only signs of an ulcer. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impaired function of the kidney or congestive heart failure, and use of NSAIDs in these patients should be cautious. People who are allergic to other NSAIDs, including aspirin, should not use ibuprofen. Individuals with asthma are more likely to experience allergic reactions to ibuprofen and other NSAIDs. Fluid retention (edema), blood clots, heart attacks, hypertension and heart failure have also been associated with the use of NSAIDs.

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 详细处方信息以本药内容附件PDF文件(201161522263621.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2011-6-16
附件:
 
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