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 详细处方信息以本药内容附件PDF文件（201152419124428.pdf）的“原文Priscribing Information”为准
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部分中文丙酸氟替卡松处方资料（仅供参考）

辅舒良/丙酸氟替卡松鼻喷雾剂
【化学名称】(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester

【药品名称】通用名称：丙酸氟替卡松鼻喷雾剂
  　　   　  汉语拼音：bingsuanfutikasongbipenwuji

【成　　份】丙酸氟替卡松
其它成份：微晶纤维素，羧甲基纤维素钠，右旋精，吐涩80，纯净水，苯扎氟铵和苯乙醇

【适 应 症】用于预防和治疗季节性过敏性鼻炎(包括枯草热)及常年性过敏性鼻炎。

【用法用量】成人和12岁以上儿童：每个鼻孔各2喷，每日1次（每日200mg），以早晨用药为好。某些患者需每个鼻孔各2喷，每日2次，早晚各1次直至症状改善。当症状得到控制时，维持剂量为每个鼻孔1喷，每日1次。每日最大剂量为每个鼻孔不超过4喷。

【不良反应】非常常见：鼻衄。常见：与其他鼻部吸入剂一样，使用后有令人不愉快的味道和气味，头痛并可引起鼻、喉部干燥、刺激等。非常罕见：过敏/过敏样反应、支气管痉挛、皮疹、面部或舌部水肿、鼻中隔穿孔、青光眼、眼压升高及白内障等。

【禁　　忌】详见说明书

【注意事项】
1.应在接触过敏原之前使用本品，以防止过敏性鼻炎症状的发生。
2.必须规律地用药才能获得最大疗效，最佳疗效会在连续治疗的3～4天后才能达到。
3.如果连续使用7天，症状仍无改善或虽然症状有改善但不能完全控制，则需停药并去医院检查。
4.未经医生许可连续使用本品不得超过3个月。
5.12岁以下儿童应在医生指导下使用本品，如需长期使用应规律地监测身高。量，
6.正在服用其他糖皮质激素药物的患者使用前应咨询医师或到医院检查。
7.糖尿病患者请咨询医生。
8.孕妇及哺乳期妇女应用时应咨询医师或药师。
9.鼻孔感染或感冒发烧的患者应在医师指导下使用。
10.对本品过敏者禁用，过敏体质者慎用。
11.本品性状发生改变时禁止使用。
12.请将本品放在儿童不能接触的地方
13.儿童必须在成人监护下使用
14.如正在使用其他药品，使用本品前请咨询医师或药师。

【药物相互作用】应在接触过敏原之前使用本品，以防止过敏性鼻炎症状的发生。必须规律地用药才能获得最大疗效，最佳疗效会在连续治疗的3~4天后才能达到。如果连续使用7天，症状仍无改善或虽然症状有改善但不能完全控制，则需停药并去医院检查。未经医生许可连续使用本品不得超过3个月。12岁以下儿童应在医生指导下使用本品，如需长期使用应规律地监测身高。正在服用其他糖皮质激素药物的患者使用前应咨询医师或到医院检查。糖尿病患者请咨询医生。孕妇及哺乳期妇女应用时应咨询医师或药师。鼻孔感染或感冒发烧的患者应在医师指导下使用。对本品过敏者禁用，过敏体质者慎用。本品性状发生改变时禁止使用。请将本品放在儿童不能接触的地方。儿童必须在成人监护下使用。如正在使用其它药品，使用本品前请咨询医师或药师。

【药代动力学】推荐剂量经鼻给药后，丙酸氟替卡松的血浆浓度很低，水溶性鼻喷雾剂的系统生物利用度也很低（平均值为0.5t%，中值为0.36%）。静脉给药后，丙酸氟替卡松的药代动力学与剂量成正比，为三次方关系，由于胃肠道吸收不完全和广泛的首过效应，绝对口服生物利用度可忽略不计（<1%），丙酸氟替卡松在体内分布广泛（Vss约为300升），血浆蛋白结合率为91%，静脉给药后，丙酸氟替卡松具很高的清除率（估计CL为1.1升/分），表明广泛的肝脏代谢。由CYP3A4酶代谢为无活性的羧基衍生物。在3—4小时内，血浆蜂浓度减少约98%，在终末半衰期时（约为8小时），仅有很低的浓度存在血浆中，口服丙酸氟替卡松后，87-100%以原药或代谢物经粪便排汇。对于大多数病人，通过鼻腔给药，丙酸氟替卡松一般不引起HPA抑制。然而，不同的患者发生可能全身反应的情形差异很大，所以应采用能有效抑制症状的最小剂量。儿童用药的药代动力学与成人的一致。

【包　　装】瓶

GENERIC NAME: FLUTICASONE SPRAY - NASAL (flew-TICK-uh-sown)

BRAND NAME(S): Flonase

USES: This medication is a corticosteroid that works directly on the nasal passages to reduce swelling and inflammation. Fluticasone is used to relieve seasonal and year-round, allergic and non-allergic nasal symptoms such as itching, runny or stuffy nose, postnasal drip and sneezing in adults and children 4 years of age and older.

HOW TO USE: Read the Patient Information Leaflet which contains instructions for proper use of this medication. Consult your doctor or pharmacist if you have any questions.Gently blow your nose before using this drug. Shake the container gently before each use. Follow the instructions on how to properly prime the bottle if you are using it for the first time or if you have not used it for a week or more.Use this medication usually once or twice a day as directed by your doctor. Do not use more than 2 sprays in each nostril daily as this may increase the risk of side effects. Avoid spraying this medication in your eyes. Follow the detailed instructions for using the spray and cleaning the applicator.Use this medicine regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.Keep track of the number of sprays used from each container. Discard the container after you have used the number of sprays specified on the manufacturer's package.This medication does not work immediately. It may take several days before the full benefit of this drug is seen. Inform your doctor if your condition persists or worsens.

SIDE EFFECTS: Nasal dryness or irritation, nausea, vomiting, wheezing, or cough may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Although unlikely, long-term use of nasal corticosteroids may cause fungal infections of the nose or throat. Tell your doctor immediately if you develop any of the following: fever, nasal pain, severe sore throat, pain when swallowing, white patches on the back of the throat.Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: severe nosebleeds or nasal pain.A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using fluticasone, tell your doctor or pharmacist if you are allergic to it, or if you have any other allergies.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: recent nasal ulcers/trauma/surgery.Before using this medication, tell your doctor or pharmacist your medical history, especially of: tuberculosis, untreated or active infections, herpes infection of the eye, decreased adrenal gland function, eye disease (glaucoma).Avoid exposure to chickenpox or measles infection while using this medication. If you are exposed to these infections, seek immediate medical attention.Though very unlikely, it is possible this medication will be absorbed into your bloodstream. This may have undesirable consequences that may require additional corticosteroid treatment. This is especially true for children and for those who have used this drug for an extended period of time and if they also have serious medical problems such as serious infections, injuries, or surgeries. This precaution applies for up to one year after stopping use of this drug. Tell your doctor immediately if any of the following side effects occur: vision problems, persistent headache, increased thirst or urination, unusual weakness or weight loss, dizziness. Consult your doctor or pharmacist for more details, and inform them that you use (or have used) this medication.Caution is advised when using this drug in children. Though it is unlikely to occur with nasal corticosteroids (fluticasone), this medication may temporarily slow down a child's rate of growth, but it will probably not affect final adult height. Monitor your child's height periodically.This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other forms of corticosteroids (e.g., oral prednisone, inhaled triamcinolone), natalizumab, drugs affecting the removal of fluticasone from your system (potent CYP 3A4 inhibitors such as ketoconazole, ritonavir).This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Do not share this medication with others.Inform all your doctors you use, or have used, this medication.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature between 39-86 degrees F (4-30 degrees C) away from light. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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 详细处方信息以本药内容附件PDF文件（201152419124428.pdf）的“原文Priscribing Information”为准
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