---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201152300545836.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文双嘧达莫处方资料（仅供参考）

英文药名: Persantine (Dipyridamole Tablets)

中文药名: 潘生丁（双嘧达莫片）

药品名称
通用名：双嘧达莫片（潘生丁）
别名: 哌醇定; 联嘧啶氨醇; 骈嘧哌胺醇; 潘散宁; 双嘧达莫; 双嘧哌胺醇; 骈嘧啶氨醇
英文名：Dipyridamole, Persantine

规格
25mg, 50mg, 75mg, 100mg

药理毒理
具有抗血栓形成作用。双嘧达莫抑制血小板聚集，高浓度（50 μg/ml）可抑制血小板释放。作用机制可能为⑴抑制红细胞摄取腺苷，而腺苷是一种血小板反应抑制剂；⑵抑制磷酸二酯酶，使血小板内环磷酸腺苷（cAMP）增多；⑶抑制血栓烷素A2（TXA2）形成，TXA2为血小板活性的强力激动剂；⑷增强内源性PGI2。双嘧达莫对血管有扩张作用。犬经十二指肠给予双嘧达莫0.5~4.0 mg/kg产生剂量相关性体循环和冠状血管阻力降低，体循环血压降低和冠脉血流增加。给药后24分钟起效，作用持续约3小时。静脉注射0.025~2.0 mg/kg后观察到类似效应。

药代动力学
口服吸收迅速，平均达峰浓度时间约75分钟，血浆半衰期为2～3小时。与血浆蛋白结合率高。在肝内代谢，与葡萄糖苷酸结合，从胆汁排泌。

适应症
对冠状动脉有较强的扩张作用，故临床上用于冠心病与阿斯司匹林合用预防急性心肌梗塞、预防一过性脑缺血，维持冠状动脉搭桥术的畅通。

用法用量
口服：１日３次，每次２５～５０ｍｇ，饭前１小时服。在症状改善后，可改为每日５０～１００ｍｇ，２次分服。
深部肌注：每次１０ｍｇ，６小时１次。
任何疑问，请遵医嘱！

注意事项
1.可有头痛、眩晕、恶心、呕吐、腹泻等不良反应。
2.不宜与葡萄糖以外的其他药物混合注射。
3.与肝素合用可引起出血倾向。
4.偶尔发生皮疹。

GENERIC NAME: DIPYRIDAMOLE - ORAL (dye-peer-ID-ah-mole)

BRAND NAME(S): Persantine

USES: This medication is used in combination with "blood thinners" such as warfarin to keep clots from forming after heart valve replacements. Clots are a serious complication that can cause strokes, heart attacks, or blocked blood vessels in the lungs (pulmonary embolisms). Dipyridamole belongs to a class of drugs known as platelet inhibitors. It helps to keep blood flowing by stopping platelets from clumping together and by keeping heart blood vessels open.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This drug may also be used to reduce the risk of stroke in patients who are at higher risk of clots, such as those who have had "mini-strokes" (transient ischemia attacks), stroke, heart attack, surgery, or heart valve disease.

HOW TO USE: Take this medication by mouth, usually 4 times daily or as directed by your doctor. This medication is best taken on an empty stomach, but it may be taken with meals if stomach upset occurs.Dosage is based on your medical condition and response to therapy.Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day.Do not stop taking this medication without consulting your doctor.

SIDE EFFECTS: Dizziness, stomach upset, diarrhea, vomiting, headache, and flushing may occur, particularly at first as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these rare but very serious side effects occur: weakness, fainting, stomach pain, pounding/rapid heartbeat, yellowing of eyes/skin, dark urine, unusual bleeding/bruising.Seek immediate medical attention if any of these rare but very serious side effects occur: chest pain, confusion, severe headache, slurred speech, vision changes, weakness on one side of the body.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before taking dipyridamole, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: other heart problems (e.g., severe coronary artery disease, recent heart attack, low blood pressure), liver disease.This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.Before having surgery, tell your doctor or dentist that you are using this medication.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.If you are currently taking aspirin, consult your doctor promptly and ask whether to continue or stop taking it with this medication for your specific condition (e.g., stroke prevention). If you are not currently taking aspirin, consult your doctor before starting it for any medical condition.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: adenosine, "blood thinners" (e.g., heparin, enoxaparin, dalteparin, ardeparin, fondaparinux, tinzaparin), other medicines that affect platelets (e.g., ticlopidine, abciximab, eptifibatide, lepirudin), neostigmine, pyridostigmine, valproic acid.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents should call the US National Poison Hotline at 1-800-222-1222. Canada residents should call a provincial poison control center.

NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., liver function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

STORAGE: Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-800-854-1166 (USA) or 1-800-668-1507 (Canada).

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201152300545836.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------