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  药店国别: 美国药房
产地国家: 美国
所属类别: 作用于消化系统药物->胃溃疡
处方药:处方药
包装规格: (140/125/125)毫克/胶囊 120胶囊/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
AXCAN SCANDIPHARM
生产厂家英文名:
AXCAN SCANDIPHARM
该药品相关信息网址1:
http://www.drugs.com/pylera.html
该药品相关信息网址2:
http://www.rxlist.com/pylera_capsules-drug.htm
原产地英文商品名:
PYLERA (140/125/125)mg/cap 120caps/bottle
原产地英文药品名:
BISMUTH SUBCITRATE POTASSIUM/METRONIDAZOLE/TETRACYCLINE HCL
中文参考商品译名:
PYLERA (140/125/125)毫克/胶囊 120胶囊/瓶
中文参考药品译名:
枸橼酸铋钾/甲硝唑/盐酸四环素
原产地国家批准上市年份:
2006/09/28
英文适应病症1:
Duodenal ulcer
英文适应病症2:
Gastric ulcer
英文适应病症3:
Chronic gastritis
临床试验期:
完成
中文适应病症参考翻译1:
十二指肠溃疡
中文适应病症参考翻译2:
胃溃疡
中文适应病症参考翻译3:
慢性胃炎
药品信息:

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 详细处方信息以本药内容附件PDF文件(201141720383123.pdf)的“原文Priscribing Information”为准
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部分中文Pylera处方资料(仅供参考)

    Pylera是一种专利的3合1三重治疗药,用于清除幽门螺杆菌(现被认为是胃及十二指肠溃疡的主要病因)。Pylera胶囊含biskalcitrate 钾140mg,甲硝唑125mg和盐酸四环素125mg。它在美国的专利技术到2018年12月期满。一项包括275例有十二指肠溃疡史病人的北美临床试验,对Pylera与每日两次20mg奥美拉唑(omeprazole)联用与广泛使用的OAC三重治疗[奥美拉唑20mg,阿莫西林 (amoxicillin)1g和克拉霉素(clarithromycin)500mg,全都每天给药2次]进行了比较。根据意向治疗分析,清除率尽管未达到统计学上显著性,分别为88% 和83%,但也表明用Pylera更为有利。
 
    Pylera生产新药治疗十二指肠溃疡、胃溃疡、慢性胃炎,因为十二指肠溃疡、胃溃疡、慢性胃炎的主要病因是由幽门螺杆菌引起的,采用适量的Pylera,可以消灭幽门螺杆菌。Pylera采用三合一:bismuth subcitrate potassium、metronidazole和tetracycline HCl。此药必须与胃药奥美拉唑一起服用。

PYLERA
Generic Name for PYLERA
Bismuth subcitrate potassium 140mg, metronidazole 125mg, tetracycline HCl 125mg; caps.

Legal Classification:
Rx

Pharmacological Class for PYLERA
Antimicrobial/antibiotics.

Manufacturer of PYLERA
Axcan Pharma
 
Indications for PYLERA
To eradicate H. pylori, in combination with omeprazole, in patients with H. pylori infection and duodenal ulcer disease (active or history of).

Adult dose for PYLERA
Take with 8 oz water. 3 caps 4 times daily after meals and at bedtime for 10 days (give with omeprazole 20mg twice daily with breakfast and dinner for 10 days).

Children's dosing for PYLERA
See Contraindications.

Contraindications for PYLERA
Renal or hepatic impairment. Pediatric patients. Pregnancy (Cat.D). Nursing mothers.

Warnings/Precautions for PYLERA
Blood dyscrasias. CNS disease. Discontinue if abnormal neurological signs or skin erythema occurs. Avoid sun, UV light.

Interactions for PYLERA
Avoid alcohol during and for at least 1 day after therapy. Recent (within 2 weeks) therapy with disulfiram: not recommended. May antagonize oral contraceptives (use non-hormonal backup method). May interfere with bactericidal anti-infectives (eg, penicillin). Tetracycline absorption reduced by antacids containing aluminum, magnesium, or calcium; and by iron, zinc, sodium bicarbonate, and dietary calcium (clinical significance unknown). Fatal renal toxicity with methoxyflurane. Metronidazole levels increased by cimetidine, others that inhibit hepatic microsomal enzymes. Metronidazole levels decreased by phenytoin, phenobarbital, other drugs that induce hepatic microsomal enzymes. Monitor phenytoin, lithium, anticoagulants. May interfere with GI X-rays, liver function tests, others.

Adverse Reactions for PYLERA
GI effects (diarrhea, dyspepsia, abdominal pain, nausea, gastritis, flatulence), darkening of tongue and/or stool, headache, flu syndrome, taste perversion, asthenia, superinfection (eg, vaginitis), dizziness, rash.

How is PYLERA supplied?
Caps—120

Related Disease:
Ulcers, duodenal

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 详细处方信息以本药内容附件PDF文件(201141720383123.pdf)的“原文Priscribing Information”为准
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2011-4-18更新

更新日期: 2014-2-9
附件:








201141720383123.pdf    

 
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