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  药店国别: 新西兰药房
产地国家: 新西兰
所属类别: 心血管系统药物->降血脂药物
处方药:处方药
包装规格: 250毫克/胶囊 30胶囊/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
辉瑞
生产厂家英文名:
pfizer
该药品相关信息网址1:
http://www.netdoctor.co.uk/medicines/100001923.html
原产地英文商品名:
OLBETAM 250mg/cap 30caps/box
原产地英文药品名:
ACIPIMOX
中文参考商品译名:
乐脂平 250毫克/胶囊 30胶囊/盒
中文参考药品译名:
阿西莫司
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Fat metabolism disorders
英文适应病症2:
Ⅳ hyperlipidemia
英文适应病症3:
High cholesterol
英文适应病症4:
Ⅴ hyperlipidemia
英文适应病症5:
Hyperlipoproteinemia type Ⅴ
临床试验期:
完成
中文适应病症参考翻译1:
脂肪代谢失调
中文适应病症参考翻译2:
Ⅳ型高脂血症
中文适应病症参考翻译3:
高胆固醇
中文适应病症参考翻译4:
Ⅴ型高脂血症
中文适应病症参考翻译5:
Ⅴ型高脂蛋白血症
药品信息:

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 详细处方信息以本药内容附件PDF文件(201141019220615.pdf)的“原文Priscribing Information”为准
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部分中文乐脂平处方资料(仅供参考)

乐脂平 Olbetam

【分类】调节血脂及抗动脉硬化药

【别名】阿西莫司;比莫酸;乐脂平,氧甲吡嗪,甲氧吡嗪

【外文名】Olbetam,

【性状】结晶性粉末,不溶于水。

【药理作用】通过抑制脂肪组织的分解,使游离脂肪酸的生成减少,从而降低了肝脏内甘油三酯的合成。此外还有抑制肝脂肪酶活性和抑制极低密度、低密度脂蛋白合成及激活脂蛋白脂肪酶的作用,使血中甘油三酯和总胆固醇降低而高密度脂蛋白则升高。口服后由肾肠道吸收完全,服后2小时血药达峰值,与蛋白不结合,不经代谢以原形从尿排出,半衰期为2小时 医学 教育网搜集整理 。 医学 教育网搜集整理

【适应症】治疗脂肪代谢失调及血中高甘油三酯(Ⅳ型高脂血症)者,高胆固醇(Ⅱ**a型高脂血症)及甘油三酯与胆固醇同时升高的Ⅱ**b、Ⅲ、Ⅴ型高脂血症。适用于Ⅱ、Ⅲ、Ⅳ及Ⅴ型高脂蛋白血症,对Ⅳ和Ⅱ型高脂蛋白血症的疗效好于Ⅲ和Ⅴ型。

【用量用法】
①每日剂量依据血中甘油三酯及胆固醇水平作个别调整,平均每日剂量:1胶囊,分2~3次饭后服。建议用药:Ⅳ型高脂血症用每日2次,每次1胶囊;Ⅱ、Ⅲ、Ⅴ型高脂血症每日用3次,每次1胶囊。严重病人每日用量可达1200mg(6胶囊),仍可安全地长期服用。已有肾功能障碍者,可根据肌酐清除率酌情减量。清除率每分钟在80~40ml之间,每日服1胶囊,清除率每分钟在40~20ml,则每隔日1胶囊。
②口服:250mg/次,一般每日2-3次,根据病情酌情调整。对较严重者可增量,每日不超过1200mg。对肾损伤患者,可根据肌酐清除率酌情减量,250mg/日或隔日250mg/日。 医学 教育网搜集整理

【注意事项】
1.偶有皮肤潮红及瘙痒,尤其在刚开始服药时,但继续用药,此现象会很快消失。
2.对本品过敏及消化道溃疡者禁用。孕妇及哺乳期妇女慎用。肾功能衰竭者需减少剂量。用药期间应保持低胆固醇和低脂肪饮食。

【规格】胶囊:每粒250mg。

How does it work?
Acipimox is a lipid (fat) lowering medicine. Its overall effect is to reduce the amount of very low density lipoproteins (VLDL) and low density lipoproteins (LDL) in the blood. These can be referred to as 'bad fats' as they are one of the factors responsible for heart disease. Acipimox also increases the amount of high density lipoproteins (HDL) in the blood. These can be referred to as 'good fats', as they are not involved in causing heart disease.

VLDL is made by the liver from triglycerides. Triglycerides may be consumed in the diet or released from stores in fat tissue. Triglycerides must be broken down into their components (fatty acids) before they can be released from fat tissue. Once released, these fatty acids are used to reform triglycerides in the liver, which are then used to form VLDL and LDL. Acipimox works by preventing the breakdown of triglycerides in fatty tissue. It therefore prevents the release of fatty acids and the subsequent formation of triglycerides and VLDL by the liver.

LDL is made when VLDL is broken down in muscle and fat cells. As acipimox results in lowered levels of VLDL in the blood, it therefore also decreases the blood levels of LDL.

Reducing the blood levels of these 'bad fats' reduces the risk of heart disease. It is best to try to reduce VLDL and LDL by dietary means ie. by consuming fewer fatty foods. However, this alone may be ineffective, or high VLDL and LDL levels may be inherited. In these cases, lipid lowering medicines are used to help reduce 'bad fat' levels.

What is it used for?
High levels of fats (lipids) such as cholesterol and triglycerides in the blood (hyperlipidaemia)

Use with caution in
Mild to moderately decreased kidney function

Not to be used in
Moderate to severely decreased kidney function
Peptic ulcer

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

The safety of this medicine during pregnancy and breastfeeding is not established. It is not recommended for use during pregnancy or breastfeeding. Consult your doctor for further advice.

Label warnings
Take this medication with or after food.

Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Headache
Rash
Itching (pruritus)
Abdominal pain
Diarrhoea
Heartburn
Severe swelling of lips, face or tongue (angioedema)
Flushing
Dry eyes
Narrowing of the airways (bronchospasm)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
There are no significant interactions reported with this medicine.

Other medicines containing the same active ingredients
Acipimox 

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 详细处方信息以本药内容附件PDF文件(201141019220615.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

2011-4-11更新

更新日期: 2011-4-11
附件:






201141019220615.pdf    

 
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