您好,欢迎光临世界标品! 登录 注册(订药物标准品请用邮件联系我们)

中国医药研发对照标品提供商
Non-clinical Research-used
Medicine Sample Provider

当前本网站药物产品种数共 8390 处方药 8017 非处方药 267 保健品/医疗用具 106

世界标品医药目录搜索(中英文):
世界各国官方药品目录搜索(英文):
世界标品医药知识搜索(中英文):

联系方式
国际免费电话:
QQ客服1:1793093587
QQ客服2:1586083059
QQ客服3:2786706041
QQ客服6:2992753224
QQ客服7:2394834588

咨询邮箱:
scimed.shanghai@shijiebiaopin.com
info@shijiebiaopin.com
pharmacy.shijiebiaopin1@gmail.com
pharmacy.shijiebiaopin2@gmail.com

  药店国别: 英国药房
产地国家: 美国
所属类别: 抗病毒药物->抗艾滋病药物
处方药:处方药
包装规格: (300/150/300)毫克/片 60片/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
VIIV HLTHCARE
生产厂家英文名:
VIIV HLTHCARE
该药品相关信息网址1:
http://www.drugs.com/trizivir.html
该药品相关信息网址2:
http://www.rxlist.com/trizivir-drug.htm
该药品相关信息网址3:
http://www.aidsmeds.com/archive/Trizivir_1583.shtml
原产地英文商品名:
TRIZIVIR (300/150/300)mg/tab 60tabs/bottle
原产地英文药品名:
ABACAVIR SULFATE/LAMIVUDINE/ZIDOVUDINE
中文参考商品译名:
三协唯 (300/150/300)毫克/片 60片/瓶
中文参考药品译名:
硫酸阿巴卡韦/拉米夫定/齐多夫定
原产地国家批准上市年份:
2000/11/14
英文适应病症1:
HIV
临床试验期:
完成
中文适应病症参考翻译1:
艾滋病毒
药品信息:

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(2010122719411039.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文三协唯处方资料(仅供参考)

英文药名: Trizivir (Abacavir/Lamivudine/Zidovudine Tablets)

中文药名: 三协唯(阿巴卡韦~拉米夫定~齐多夫定片)

成份
每片薄膜包衣片 阿巴卡韦 Abacavir 300mg, 拉米夫定 Lamivudine 150mg, 齐多夫定 Zidovudine 300mg

适应症
治疗人类免疫缺陷病毒(HIV)感染的成人。

用量
≥18岁 每天2次,每次1片。不应用于体重<40 kg的患者,因为本品是剂量固定的片剂,不能减少剂量。
本品可与或不与食物同服。
任何疑问,请遵医嘱!

禁忌
禁用于对本药任一成分过敏者、终末期肾病、肝损害、中性粒细胞数<0.75 x 109/L)或血红蛋白水平<7.5 g/dL或4.65 mmol/L的患者。

注意事项
用药期间应仔细监测血液学参数和胰腺炎的症状、体征,提示有胰腺炎时,应立即停用本品。妊娠妇女慎用。哺乳妇女用药期间不要母乳喂养。

不良反应
过敏反应。拉米夫定:恶心、呕吐、腹泻、腹痛、头痛、皮疹、发热、不适、疲劳。齐多夫定:贫血、中性粒细胞和白细胞减少。

药物相互作用
经肝脏代谢,特别是通过葡萄糖醛酸化作用清除的药物,可能会抑制齐多夫定的代谢。

MIMS药物分类
抗病毒药 (Antivirals)

Trizivir (abacavir + zidovudine + lamivudine)
What is Trizivir?
Trizivir is an HIV medication. It is in a category of HIV medicines called nucleoside reverse transcriptase inhibitors (NRTIs). Trizivir prevents HIV from entering the nucleus of healthy CD4 cells. This prevents the cells from producing new virus and decreases the amount of virus in the body.
 
Trizivir is marketed by ViiV Healthcare. It was approved by the U.S. Food and Drug Administration (FDA) for use by people living with HIV in 2000.
 
Trizivir is a combination of three previously approved drugs: 300mg of Retrovir (zidovudine), 150mg of Epivir (lamivudine), and 300mg of Ziagen (abacavir). Trizivir should be prescribed by a healthcare provider for patients who need to take all three drugs. For patients only taking zidovudine and lamivudine, a combination tablet called Combivir is available. For patients only taking abacavir and lamivudine, a combination tablet called Epzicom is available. Also, any of these three drugs can be purchased individually for use in combination with other HIV drugs.
 
A patient assistance program (PAP) has been established for people living with HIV who do not have private or public health insurance and are unable to afford Trizivir. To learn more about the PAP for Trizivir, call 888-825-5249 or refer to the program's website for more information. For those with private health insurance, a program has been established to help cover each Trizivir co-payment, up to $100 every month. To learn more about this co-pay program, check out mysupportcard.com.

What is known about Trizivir?
Trizivir is taken twice daily, one tablet in the morning and one tablet in the evening, with or without food. It is approved by the FDA for use with or without other HIV medications. Similarly, Trizivir should not be taken at the same time as Retrovir, Ziagen, Epivir, Epzicom or Combivir.
 
Trizivir should not be any more or less effective than Retrovir, Epivir, and Ziagen taken as separate pills together. However, it is considered to be a much more convenient way of taking these three HIV drugs.
 
For HIV-positive adults beginning anti-HIV drug therapy for the first time, Trizivir—used without other HIV medications—is listed as a "possible" treatment option by the United States Department of Health and Human Services in its treatment guidelines. This means that it can be used, but because of lingering concerns about effectiveness and/or safety, it is considered to be inferior to "preferred" or "alternative" drug combinations. The use of Trizivir without other HIV medications is only recommended when a preferred or alternative protease inhibitor (PI)- or a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen cannot be used because of side effects or significant drug-drug interactions. To learn more about these recommendations and options, click here.
 
See the "What is known about..." sections of Retrovir, Epivir, and Ziagen for information about possible drug resistance.

What about drug interactions?
Trizivir should not be taken at the same time as Emtriva or Truvada (containing Viread and Emtriva). This is because the Epivir in Trizivir and Emtriva are very similar and it is not believed that combining these two anti-HIV drugs will make a regimen any more effective against the virus.
 
See the "What about drug interactions?" sections of sections of Retrovir, Epivir, and Ziagen.

What about side effects?
A rare but potentially serious side effect of Retrovir (AZT), one of the three drugs in Trizivir, is myopathy (damage to the muscles, including the heart). People who use Retrovir for a long period of time, meaning several years, are at the greatest risk for myopathy. General symptoms of myopathy include weakness of limbs, usually proximal (located close to the center of the body).
 
Bone marrow problems, such as decreased production of red blood cells and/or white blood cells, can occur in people talking Retrovir, one of the three active drugs in Trizivir. Contact your doctor immediately if you develop unusual fatigue, pale skin, sore throat, fever, or chills, which may be signs of bone marrow problems.
 
An important side effect that doctors and patients need to be aware of is "hypersensitivity." Approximately 5 percent of people who take Ziagen (abacavir), one of the three medications in Trizivir, are allergic to it. This can be serious and generally requires that Trizivir be stopped, and that Trizivir or Ziagen should not be taken again. A hypersensitivity reaction usually appears during the second week of therapy, but it can take as long as six weeks to notice any symptoms. The most common symptoms are fever and rash, followed by headaches, stomach upset, feeling sick or tired, sore throat, cough, and shortness of breath. These symptoms usually get worse over time and it is important that you report them to your doctor immediately. If you need to stop Trizivir because of this hypersensitivity reaction, you will still be able to take Retrovir and Epivir, the two other drugs in Trizivir.

An inexpensive laboratory test is available to look for an inherited gene, called HLA-B*5701, that has been linked to the hypersensitivity reaction in HIV-positive people taking Trizivir. While not all people with this gene experience an allergic reaction while taking Trizivir, most do. In turn, if you are tested and found to have this gene, Trizivir (or other medications containing abacavir) should either be avoided or used with caution. If you and your doctor are thinking about starting Trizivir or another abacavir-containing medication for the first time, be sure to discuss this genetic test.
 
Lactic acidosis, which can be fatal, and severe liver problems have been reported in people taking nucleoside reverse transcriptase inhibitors (NRTIs), including Retrovir, Epivir, and Ziagen, the three active drugs in Trizivir. Contact your doctor immediately if you experience nausea, vomiting, or unusual or unexpected stomach discomfort; weakness and tiredness; shortness of breath; weakness in the arms and legs; yellowing of the skin or eyes; or pain in the upper stomach area.
 
HIV drug regimens containing NRTIs, including Trizivir, can cause increased fat levels (cholesterol and triglycerides) in the blood, abnormal body-shape changes (lipodystrophy; including increased fat around the abdomen, breasts, and back of the neck, as well as decreased fat in the face, arms, and legs), and diabetes. These side effects of HIV drug therapy are reviewed in our lessons on Lipodystrophy, Facial Lipoatrophy, and Risks To Your Heart (Hyperlipidemia).
 
Taking medications like Trizivir that contain Ziagen may increase the risk of a heart attack. The reason for the increased risk associated with Ziagen, compared with other NRTIs, has not been established. The risk of a heart attack is highest among people living with HIV taking Ziagen who have other cardiovascular disease (CVD) factors, including high blood pressure, high lipids, diabetes, cigarette smoking, family history of CVD.
 
If you have hepatitis B and HIV and plan to stop taking Trizivir, your doctor might want to frequently check your liver enzymes after stopping treatment. This is because the Epivir in Trizivir is also active against the hepatitis B virus (HBV). If Epivir is stopped abruptly, it can cause liver disease to "flare" and damage the liver.
 
See the "What about side effects?" sections of Retrovir, Epivir, and Ziagen for additional possible side effects.

Can pregnant women take Trizivir?
Trizivir is classified by the FDA as a pregnancy category C drug. Pregnancy category C means that animal studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks. HIV-positive women who become pregnant should discuss the benefits and possible side effects of HIV treatment to help protect their babies from HIV (see our lesson called Family Planning, Pregnancy & HIV).
 
It is not known whether Trizivir passes into breast milk and what effect they may have on a nursing baby. To prevent transmission of the virus to uninfected babies, it is recommended that HIV-positive mothers not breast-feed.

What should I tell my doctor before taking Trizivir?
Before taking this medication, tell your doctor if you have: kidney disease; liver disease (including hepatitis B); or low blood cell counts (anemia or low white blood cells).
 
Be sure to tell your doctor if you've ever taken Trizivir, Epzicom, or Ziagen in the past. If you stopped these medications in the past because of an allergic reaction, you should not take Trizivir or any medication that contains Ziagen.
 
Tell your doctors and pharmacists about all medicines you take. This includes prescription medications, over-the-counter products, or herbal/natural remedies.

Where can I learn more about clinical trials of Trizivir?
If you would like to find out if you are eligible for any clinical trials that include Trizivir, there is an interactive web site run by ACRIA, the AIDS Community Research Initiative of America.
 
Another useful service for finding clinical trials is AIDSinfo.nih.gov, a site run by the U.S. National Institutes of Health. They have "health information specialists" you can talk to at their toll-free number at 1-800-HIV-0440 (1-800-448-0440).

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(2010122719411039.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

2010-12-28更新

更新日期: 2010-12-28
附件:












2010122719411039.pdf    

 
调控比例: 100%
订购表单下载
Copyrights © 2010,2011,2012 www.ShiJieBiaoPin.com, Inc., All rights Reserved www.ShiJieBiaoPin.com, Inc.
客服工作时间:太平洋时间18:00-24:00
国际免费电话:
友情提示:以上电话为免费电话,无需您承担任何费用,世界标品提供中文客服,请您放心拨打!
电子邮箱:info.shijiebiaopin.com@gmail.com, info@shijiebiaopin.com