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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->抗高血压药物
处方药:处方药
包装规格: (32/12.5毫克)/片 90片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
阿斯利康
生产厂家英文名:
ASTRAZENECA
该药品相关信息网址1:
http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileName=ata1591.html&contentName=Atacand+HCT&contentId=87
该药品相关信息网址2:
http://www.drugs.com/cons/atacand-hct.html
原产地英文商品名:
ATACAND HCT (32/12.5mg)/tablet 90tablets/box
原产地英文药品名:
CANDESARTAN CILEXETIL/HYDROCHLOROTHIAZIDE
中文参考商品译名:
ATACAND HCT (32/12.5毫克)/片 90片/盒
中文参考药品译名:
坎地沙坦酯氢氯噻嗪
原产地国家批准上市年份:
2000/09/05
英文适应病症1:
Second-line drugs for the treatment of hypertension
临床试验期:
完成
中文适应病症参考翻译1:
作为治疗高血压的二线药物
药品信息:

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 详细处方信息以本药内容附件PDF文件(20105223265734.pdf)的“原文Priscribing Information”为准
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部分中文Atacand HCT处方资料(仅供参考)

    阿斯利康公司宣布AtacandHCT(candesartancilexetil-氢氯噻嗪,即双氢克尿噻)可在全美各地的药房出售。AtacandHCT已于2000年9月5日得到美国食品与药物管理局的批准,可作为治疗高血压的二线药物。

    当单一药物治疗降压效果不充分时,更多的医生会采用固定剂量联合使用一种以上降压药物以帮助病人达到其所期望的血压目标,这时AtacandHCT以其特有的功效面世了。近期的公共健康调查显示,在美国每5个高血压病人中仅有一个可以达到目标血压水平。随着高血压病人的需求不同,与两种药物中任何一种相比,AtacandHCT的面世在增强降压作用方面提供了多种有效的治疗的选择。

    AtacandHCT是由血管紧张素II受体阻断剂(ARB)Atacan和利尿剂双氢克尿噻配伍而成的复方制剂。AtacandHCT以两种固定剂量配伍的规格上市:32mgcandesartancilexetil和12.5mg双氢克尿噻以及16mgcandesartancilexetil和12.5mg双氢克尿噻。AtacandHCT不适用于高血压病人的初始治疗。

    已在12项近4,600高血压病人的对照临床试验中对candesartancilexetil-氢氯噻嗪复方制剂进行了评价。在设对照临床试验中,在经安慰剂组校正后,用32-12.5mg与16-12.5mg配伍剂量规格的药物,导致收缩期和舒张期血压降低14-18mmHg/8-11mmHg。AtacandHCT32-12.5mg/日可使降压效果维持24小时。

    AtacandHCT一般说来具有良好的耐受性。在临床对比实验中其不良反应的总发生率与安慰剂组差不多。

    AtacandHCT发生频率比安慰剂高2%或更多一些的最常见的不良反应有:上呼吸道感染(3.6%比3.0%)、眩晕(2.9%比1.2%)、背部疼痛(3.3%比2.4%)、流感样症状(2.5%比1.9%)。作为一种直接作用于肾素-血管紧张素系统的药物,一旦发现病人已处妊娠期,AtacandHCT应尽快被停止使用。

    ARBs通过抑制血管紧张素II而发挥作用,后者为具有收缩血管作用的多肽,它造成高血压。利尿药,如氢氯噻嗪通过加强肾脏从体内排钠和排液体的能力而使血压降低。Atacand于1998年投放美国市场,并在33个国家上市。


Atacand HCT
Generic name: Candesartan cilexetil and hydrochlorothiazide

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What is Atacand HCT?
Atacand HCT is used to treat high blood pressure. This drug belongs to a family of medications known as angiotensin receptor blockers (ARBs). This type of medication stops a hormone called angiotensin II from attaching to your blood vessels. Angiotensin II normally causes arteries to narrow. As a result of taking Atacand HCT, the blood vessels relax and widen, and blood pressure is reduced. This medication also contains hydrochlorothiazide, a thiazide diuretic that helps to decrease high blood pressure as well.

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What is the most important information I should know about Atacand HCT?
Atacand HCT should not be taken during pregnancy; this drug may cause severe birth defects.

Your blood pressure should be checked before and during Atacand HCT therapy. Atacand HCT may make the blood pressure too low, especially during the first days of use. If you faint, Atacand HCT should be stopped until you can talk to your doctor.

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Who should not take Atacand HCT?
Do not take Atacand HCT if you are allergic to any of its ingredients.

Atacand HCT contains hydrochlorothiazide, so you should not take it if you have anuria (absence of urine formation), or if you are allergic to other sulfonamide-derived drugs.

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What should I tell my doctor before I take the first dose of Atacand HCT?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Atacand HCT. Also, talk to your doctor about your complete medical history, especially if you are pregnant, planning to become pregnant, or are nursing.

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What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Adults: The usual dosage of Atacand HCT is 16 milligrams (mg) once a day. Atacand HCT can be given once or twice daily, with a total dosage equal to 8-32 mg.

Hydrochlorothiazide is effective in doses of 12.5 mg to 50 mg once daily.

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How should I take Atacand HCT?
Atacand HCT can be taken with or without food. If this drug does not make your blood pressure any better, it can be given with other medications.

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What should I avoid while taking Atacand HCT?
Avoid becoming pregnant while being treated with Atacand HCT, as this can cause severe harm to your unborn baby.

Avoid excessive sweating and inadequate fluid intake, as this could cause a further decrease in your blood pressure.

Avoid taking potassium supplements or salt substitutes containing potassium without talking to your doctor first.

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What are possible food and drug interactions associated with Atacand HCT?
If Atacand HCT is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check you're your doctor before combining Atacand HCT with the following: alcohol, antidiabetic drugs, barbiturates, cholestyramine and colestipol resins, corticosteroids, lithium, narcotics, nondepolarizing muscle relaxants such as tubocurarine, nonsteroidal anti-inflammatory drugs (NSAIDs), pressor amines such as norepinephrine, and other high blood pressure medications.

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What are the possible side effects of Atacand HCT?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: back pain, cold symptoms, dizziness, electrolyte imbalances (increase/decrease in calcium, potassium, magnesium), headache, flu symptoms, upper respiratory infection

Symptoms of abnormally low blood pressure include: dizziness, feeling faint or weak, lightheadedness

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Can I receive Atacand HCT if I am pregnant or breastfeeding?
Tell your doctor if you are pregnant, planning to become pregnant, or are nursing. Atacand HCT should not be taken if you are pregnant, as it may cause severe deformities and malformations to your child's face and limbs. Also, this drug may pass into your breast milk.

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What should I do if I miss a dose of Atacand HCT?
If you miss a dose of Atacand HCT, be sure to take your dose as soon as you remember. However, do not take more than your prescribed dose on any one day.

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How should I store Atacand HCT?
Store at room temperature in a tightly closed container.

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 详细处方信息以本药内容附件PDF文件(20105223265734.pdf)的“原文Priscribing Information”为准
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更新日期: 2011-4-28
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