What is the most important information I should know about Glucovance?

Do not use Glucovance if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before taking Glucovance, tell your doctor if you have heart disease, liver disease, or a history of heart attack or stroke.

Some people have developed a life-threatening condition called lactic acidosis while taking Glucovance. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Glucovance. Be sure the surgeon knows ahead of time that you are using this medication.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them, including hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma (severe hypoglycemia can be fatal). Always keep a source of sugar available in case you have symptoms of low blood sugar.

What is Glucovance?

Glucovance is a combination of two oral diabetes medicines that help control blood sugar levels.

Glucovance is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes.

Glucovance may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Glucovance?

Some people have developed a life-threatening condition called lactic acidosis while taking Glucovance. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
You may be more likely to develop lactic acidosis if you have congestive heart failure.

Do not use Glucovance if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
Before taking this medication, tell your doctor if you have:

• heart disease;
• liver disease; or
• a history of heart attack or stroke.

If you have any of these conditions, you may not be able to use Glucovance, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Glucovance passes into breast milk or if it could harm a nursing baby. Do not take Glucovance without first talking to your doctor if you are breast-feeding a baby. Older adults may have a higher risk of developing lactic acidosis. Talk with your doctor about your individual risk.

部分Glucovance中文资料（仅供参考）

FDA批准了一种治疗糖尿病的新药

Glucovance是格华止和一种普通的糖尿病药丸Metformin的混合制剂，主要用于治疗II型糖尿病和糖尿病发作的成人。

Glucovance最常见的副作用为腹泻、恶心、胃不适。较少发生的副作用有低血糖症如头晕、头昏、颤抖、饥饿等。

在罕见病例中，Glucovance偶尔引起乳酸性酸中毒，对一半以上的此种患者而言可以是致命的。乳酸性酸中毒主要发生于那些肾脏功能不正常的患者中，因此如果有肾脏疾病则不能服用这种药物。