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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->降血脂药物
处方药:处方药
包装规格: (750/20)毫克/片 90片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
雅培制药公司
生产厂家英文名:
Abbott Laboratories Ltd
该药品相关信息网址1:
http://www.Advicor.com/
原产地英文商品名:
ADVICOR(750/20)mg/tab 90tabs/box
原产地英文药品名:
NIACIN/LOVASTATIN
中文参考商品译名:
ADVICOR(750/20)毫克/片 90片/盒
中文参考药品译名:
烟酸/洛伐他汀
原产地国家批准上市年份:
2001/12/17
英文适应病症1:
primary hypercholesterolemia
英文适应病症2:
Mixed dyslipidemia
英文适应病症3:
Hyperlipidemia
临床试验期:
完成
中文适应病症参考翻译1:
原发性高胆固醇血症
中文适应病症参考翻译2:
混合型异常脂血症
中文适应病症参考翻译3:
高血脂
药品信息:

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 详细处方信息以本药内容附件PDF文件(200812301084121.pdf)的“原文Priscribing Information”为准
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 复方烟酸洛伐他汀缓释片


英 文 名:Niacin Extended-Release and Lovastatin Tablets
中 文 名:复方烟酸洛伐他汀缓释片
商 品 名:ADVICOR
类    别:循环系统药物/调节血脂药
注册分类:化学药品3类(2)
研发厂家:KOS Pharmaceuticals, Inc
上市情况:2001年12月获FDA批准。
适 应 症:原发性高胆固醇血症和混合血脂异常。
剂 型:片剂

      复方烟酸缓释片为烟酸和洛伐他汀的复方制剂,原创企业为美国Kos公司,该产品于2001年12月17日首先在FDA获得批准,商品名为AdvicorTM,是全球开发上市的第一个复方降脂药物。
       高血脂是导致冠心病和中风的主要原因之一,而冠心病、中风等心脑血管疾病又是全球人口的主要死因。随着我国人口老龄化及生活水平的提高,特别是饮食习惯的改变,高血脂病人也在增多。据文献报道,调节血脂药物年销售额已达100亿美元。
       目前临床上常用的调节血脂药主要分为两类,一类是以降低胆固醇为主的他汀类,另一类是以降低甘油三酯为主的苯氧酸类,虽然它们都有一定药效,但疗效相对单一。
       烟酸属维生素B类,调节血脂肯定,是唯一一个能使所有血脂成分朝正方向发展变化的药物,已被临床证明可以降低心血管疾病的发病率和总死亡率。美国国立卫生研究院和心脏协会已指定烟酸缓释片作为脂代谢紊乱一线治疗药物,2000年该品种的年销售额在美国达2.5亿美元。洛伐他汀为他汀类高效降血脂药物。1992年该药在美国销售额已达15亿美元,该药作用强,疗效高,副作用轻微,因其安全、高效、低毒的特点已成为目前全球最常用的一类降血脂药物。
      烟酸与洛伐他汀体内代谢过程具有明显的差异,将烟酸部分作为缓释部分,洛伐他汀作为常释部分,制成复合制剂,既使各组分在体内发挥协同作用,最大限度地发挥药效,又可降低药物的毒副作用,减少血药浓度在体内的波动,减少病人服药次数。

2007年底雅培又有一项重要购并正在出炉。为加强制药业务,雅培今天宣布收购位于纽约州新泽西的柯氏制药。该公司特长于脂质代谢类药物,极佳地补充了雅培的药物产品类别。柯氏在市场上的成功产品,如 Advicor (复方产品治疗脂质代谢紊乱)以及其它即将上市产品也将带来雅培,形成有良好前景的产品线。

Advicor is a once-a-day medication that along with diet helps you manage high cholesterol when diet and other nondrug measures alone have been unsuccessful and when treatment with niacin and lovastatin are appropriate.

Uses and Important Safety Information You Should Know About Advicor® (niacin extended-release/lovastatin tablets)
Uses
■ADVICOR® (niacin extended-release/lovastatin tablets) is a prescription medication used with diet when a diet low in saturated fat and cholesterol and other nondrug measures alone have not been successful.
■ADVICOR is used to improve cholesterol levels in people with high cholesterol and when a health care provider determines that treatment with both niacin and lovastatin is appropriate.

Important Safety Information
■ADVICOR is not for everyone, including those with liver problems, stomach ulcers, or a serious bleeding problem and those allergic to any product ingredients. ADVICOR should not be used in women who are nursing, are pregnant, or may become pregnant.
■ADVICOR should not be switched for immediate-release niacin. Serious liver damage has been reported when switching to sustained-release niacin products from immediate-release niacin. You should not change your medication before checking with your health care provider.
■Your health care provider should do blood tests before and during treatment to check liver enzyme levels, as these may increase with ADVICOR use.
■ADVICOR should be used with caution if you consume large amounts of alcohol.
■If you take ADVICOR, tell your health care provider about any unexplained muscle pain, tenderness, or weakness, as this could be a sign of a serious but rare side effect. The risk of these side effects is increased when ADVICOR is taken with certain types of medications. To avoid possible drug interactions, inform your health care provider about any other medications or vitamin supplements you are taking.
■ADVICOR may cause an increase in blood sugar levels. If you have diabetes or higher than normal blood sugar levels, you should carefully check your blood sugar levels more frequently during the first few months or with ADVICOR dose changes.
■Tell your health care provider if you have a history of gout or kidney problems. ADVICOR should be used with caution in patients with kidney problems.
■If you are taking another cholesterol medication called a bile acid-binding resin (colestipol or cholestyramine) along with ADVICOR, take these medicines at least 4 to 6 hours apart.
■Flushing (warmth, redness, itching, and/or tingling of the skin) is the most common side effect, and it may subside after several weeks of consistent ADVICOR use. Flushing may vary in severity and is more likely to occur when starting therapy or during dose increases. If you take ADVICOR at bedtime, flushing will most likely occur during sleep. If you are awakened by flushing, get up slowly, especially if you feel dizzy or faint or if you take blood pressure medications.
■Other common side effects may include weakness, flu symptoms, headache, infection, pain, diarrhea, nausea, itching, and rash

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 详细处方信息以本药内容附件PDF文件(200812301084121.pdf)的“原文Priscribing Information”为准
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更新日期: 2013-5-15
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