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  药店国别: 美国药房
产地国家: 美国
所属类别: 糖尿病->2型糖尿病
处方药:处方药
包装规格: 2.5毫克/片 30片/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
阿斯利康
生产厂家英文名:
AstraZeneca
该药品相关信息网址1:
http://www.onglyza.com/
该药品相关信息网址2:
https://www.drugs.com/imprints/4214-2-5-14395.html
该药品相关信息网址3:
http://www.rxlist.com/onglyza-drug.htm
原产地英文商品名:
ONGLYZA 2.5mg/tab 30tabs/bottle
原产地英文药品名:
saxagliptin
原产地英文化合物名称:
(1S,3S,5S)-2-[(2S)-2-Amino-2-(3hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
中文参考商品译名:
ONGLYZA 2.5毫克/片 30片/瓶
中文参考药品译名:
盐酸沙格列汀
原产地国家批准上市年份:
2014/11/21
英文适应病症1:
Type II diabetes
临床试验期:
完成
中文适应病症参考翻译1:
II型糖尿病
药品信息:

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 详细处方信息以本药内容附件PDF文件(2020112418284031.pdf)的“原文Priscribing Information”为准
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部分中文Onglyza 处方资料(仅供参考)

商品名:Onglyza   

通用名:Saxagliptin沙格列汀   

CAS号:361442-04-8   

CB号:CB61856071   

化学名:(1S,3S,5S)-2-[(2S)-2-Amino-2-(3hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile, 水合物,或者 (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-210 azabicyclo[3.1.0]hexane-3-carbonitrile水合物.   

分子式:C18H25N3O2•H2O   

分子量:333.43.   

    Saxagliptin为白色到淡黄色或者淡棕色,非吸湿性,结晶性粉末。在24°C ± 3°C水中难溶,乙酸乙酯微溶,溶于甲醇,乙醇,异丙醇,乙腈,丙酮,聚乙二醇400(聚乙二醇400)。
   
    Saxagliptin为施贵宝公司的II型糖尿病最新产品。Saxagliptin属二肽基肽酶(DPP)IV抑制剂(CD26) 类新型II型糖尿病治疗新药,剂型为一日一次的口服片剂。成人患者饭后日服一次,辅之饮食控制和锻炼措施控制血糖水平。

    Saxagliptin是二肽基肽酶抑制剂类抗糖尿病治疗药物之一,为近几年关注度极高的新型II型糖尿病治疗药物。其主要是通过抑制体内的二肽酰肽酶IV(dipeptidyl peptidase IV,DDP-IV),以减少血液中胰高血糖素样多肽(GLP-1)的分解和代谢,提高血液中胰高血糖素样多肽的浓度达到提高胰岛素水平,发挥降糖作用。
   
    Onglyza最常见的副作用是上呼吸道感染,尿路感染和头痛。其他副作用主要表现为皮疹和麻疹等过敏反应。 


Onglyza
Generic Name: saxagliptin (SAX a GLIP tin)
Brand Names: Onglyza

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What is Onglyza?
Onglyza (saxagliptin) is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.

Onglyza is for people with type 2 diabetes (non-insulin-dependent) diabetes. Saxagliptin is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes.

Onglyza may also be used for other purposes not listed here.

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Important information about Onglyza
Do not use Onglyza if you are allergic to saxagliptin or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you have kidney disease or you are on dialysis, you may need a dose adjustment or special tests to safely take Onglyza.

You may take this medicine with or without food. Follow your doctor's instructions.

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking Onglyza.

Onglyza is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

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Before taking Onglyza
Do not use Onglyza if you are allergic to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

If you have kidney disease or you are on dialysis, you may need a dose adjustment or special tests to safely take Onglyza.

FDA pregnancy category B. Onglyza is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether saxagliptin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Onglyza should not be given to a child younger than 18 years old without a doctor's advice.

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How should I take Onglyza?
Take Onglyza exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from Onglyza.

You may take this medicine with or without food. Follow your doctor's instructions.

Your medication needs may change if you become sick or injured, if you have a serious infection, or if you have any type of surgery. Your doctor will tell you if any of your doses need to be changed.

Onglyza is only part of a complete program of treatment that also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

To be sure Onglyza is helping your condition, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Store Onglyza at room temperature away from moisture and heat

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What happens if I miss a dose?
Take the missed dose as soon as you remember (be sure to take the medicine with food if your doctor has instructed you to). If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

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What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine. You may have signs of low blood sugar, such as hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure (convulsions), fainting, or coma.

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What should I avoid while taking Onglyza?
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are taking Onglyza.

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Onglyza side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Onglyza: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
pain or burning when you urinate;
swelling in your hands, ankles, or feet; or
easy bruising or bleeding.

Less serious Onglyza effects may include:
runny or stuffy nose, sore throat, cough;
headache; or
stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Onglyza?
Tell your doctor about all other medications you use, especially:
conivaptan (Vaprisol);
diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);
imatinib (Gleevec);
isoniazid (for treating tuberculosis);
an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
an antidepressant such as nefazodone;
antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir); or
insulin or an oral diabetes medication such as glipizide (Glucotrol, Metaglip), glimepiride (Amaryl, Avandaryl, Duetact), glyburide (DiaBeta, Micronase, Glucovance), and others.

This list is not complete and there may be other drugs that can interact with Onglyza. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist can provide more information about Onglyza.

Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

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 详细处方信息以本药内容附件PDF文件(2020112418284031.pdf)的“原文Priscribing Information”为准
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更新日期: 2020-11-25
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