药品信息:
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(201910118201514.pdf)的“原文Priscribing Information”为准 --------------------------------------------------------------- 部分中文BICILLIN L-A处方资料(仅供参考)
【英文名称】BICILLIN L-A
【适用证】
为减少耐药菌的产生并保持Bicillin L-A和其他抗菌药物的有效性,Bicillin L-A仅应用于治疗或预防已证明或强烈怀疑由细菌引起的感染。当可获得培养物和药敏性信息时,在选择或修改抗菌疗法时应考虑它们。在缺乏此类数据的情况下,局部流行病学和易感性模式可能有助于经验性治疗的选择。
肌内青霉素G苄星胺可用于治疗因青霉素敏感性微生物而引起的感染,这种微生物对这种特殊剂型常见的血清浓度很低且很长。治疗应以细菌学研究(包括敏感性试验)和临床反应为指导。
以下感染通常会对肌内青霉素G苄星胺的适当剂量产生反应:
由于易感链球菌引起的上呼吸道的轻度至中度感染。
性病感染-梅毒,偏航,贝耶尔和品脱。
青霉素G苄星疗法可预防的医疗条件:
风湿热和/或舞蹈病-已证明用青霉素G苄星胺预防可有效预防这些疾病的复发。它也已被用作风湿性心脏病和急性肾小球肾炎的后续预防疗法。
【用法用量】
---链球菌(A组)上呼吸道感染(例如,咽炎):
成人-单次注射1,200,000单位; 老年儿科患者—单次注射900,000单位; 60磅以下的婴儿和儿科患者。300,000至600,000单位。
---梅毒:
一次,二次和潜伏期-2,400,000单位(1剂)。 晚期(三期和三期梅毒—240万单位,间隔7天,共三剂)。
先天性-2岁以下:50,000单位/ kg /体重; 2至12岁:根据成人剂量表调整剂量。
--- Yaws,Bejel和Pinta-1,200,000单位(1次注射)。
---预防-用于风湿热和肾小球肾炎。
在急性发作之后,青霉素G苄星(肠胃外)可以每月一次1,200,000单位或每两周600,000单位的剂量给药。
【警告和注意事项】
以前对任何青霉素过敏反应的病史是禁忌症。
【INDICATIONS AND USAGE】
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bicillin L-A and other antibacterial drugs, Bicillin L-A should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Intramuscular penicillin G benzathine is indicated in the treatment of infections due to penicillin-Gsensitive microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response.
The following infections will usually respond to adequate dosage of intramuscular penicillin G benzathine:
Mild-to-moderate infections of the upper-respiratory tract due to susceptible streptococci.
Venereal infections—Syphilis, yaws, bejel, and pinta.
Medical Conditions in which Penicillin G Benzathine Therapy is indicated as Prophylaxis:
Rheumatic fever and/or chorea—Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions. It has also been used as follow-up prophylactic therapy for rheumatic heart disease and acute glomerulonephritis.
【CONTRAINDICATIONS】
A history of a previous hypersensitivity reaction to any of the penicillins is a contraindication.
【DOSAGE AND ADMINISTRATION】
---Streptococcal (Group A) Upper Respiratory Infections (for example, pharyngitis):
Adults—a single injection of 1,200,000 units; older pediatric patients—a single injection of 900,000 units; infants and pediatric patients under 60 lbs.—300,000 to 600,000 units.
---Syphilis:
Primary, secondary, and latent—2,400,000 units (1 dose). Late (tertiary and neurosyphilis —2,400,000 units at 7-day intervals for three doses.
Congenital—under 2 years of age: 50,000 units/kg/body weight; ages 2 to 12 years: adjust dosage based on adult dosage schedule.
---Yaws, Bejel, and Pinta—1,200,000 units (1 injection).
---Prophylaxis—for rheumatic fever and glomerulonephritis.
Following an acute attack, penicillin G benzathine (parenteral) may be given in doses of 1,200,000 units once a month or 600,000 units every 2 weeks.
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(201910118201514.pdf)的“原文Priscribing Information”为准 --------------------------------------------------------------- |