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  药店国别: 德国药房
产地国家: 德国
所属类别: 神经系统药物->精神障碍抑郁
处方药:处方药
包装规格: 100毫克/片 50片/盒
计价单位:
  点击放大  
生产厂家英文名:
Neuraxpharm
该药品相关信息网址1:
https://www.neuraxpharm.de/en/
该药品相关信息网址2:
https://en.wikipedia.org/wiki/Doxepin
原产地英文商品名:
Doxepin neuraxpharm 100mg, 50 tabs (film coated tab)
原产地英文药品名:
Doxepin
中文参考商品译名:
多塞平 100毫克/片 50片/盒 (薄膜片膜衣片)
中文参考药品译名:
多塞平
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Anxiety
英文适应病症2:
Depression
临床试验期:
完成
中文适应病症参考翻译1:
焦虑症
中文适应病症参考翻译2:
神经性抑郁症
药品信息:

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 详细处方信息以本药内容附件PDF文件(2017101800461819.pdf)的“原文Priscribing Information”为准
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 部分中文多塞平处方资料(仅供参考)

多塞平
【英文名称】
Doxepin

【其他名称】 多塞平、多虑平、多噻平、盐酸多噻平,Adapin、Aponal、Novoxapin、Quitaxon、Sinquan、Spectra、Toruan 
 
【适应证】
常用于治疗抑郁症和各种焦虑抑郁为主的神经症,亦可用于更年期精神病,对抑郁和焦虑的躯体性疾病和慢性酒精性神病也有效。也可用于镇静及催眠。:
1.本品外用膏剂用于治疗慢性单纯性苔藓、湿疹、过敏性皮炎、特应性皮炎等。
 
【不良反应】不良反应较少。少数患者可有轻度兴奋、失眠、口干、便秘、视物模糊等,某些症状可在继续用药中自行消失。局部外用也可出现困倦和其他系统反应。最常见的局部反应是烧灼感与针刺感。

【注意事项】
1.排尿困难、眼压高、心脏疾患、癫痫、轻中度肝功能不全、肾功能不全者慎用
2.孕妇、12岁以下儿童慎用。 ③局部敷用仅能用于未破损皮肤,不能用于眼部及黏膜。

【药物相互作用】
1.本品禁止与单胺氧化酶抑制剂(如吗氯贝胺、氯吉兰、司来吉兰等)合用,因易发生致死性5-HT综合 征(表现为高血压、心动过速、高热、肌阵挛、精神状态兴奋性改 变等)。
2.与CYP2D6抑制剂(如奎尼丁、西咪替丁、帕罗西汀、 舍曲林、氟西汀等)合用,会增加本品的血药浓度,延长清除半衰期。
3.与肝药酶诱导剂(如苯妥英、巴比妥类药物、卡马西平等)合用,会使本品的血药浓度降低,清除速率加快。
4.与抗胆碱类药物或抗组胺药物合用,会产生阿托品样作用(如口干、散瞳、肠蠕动降低等)。
5.与香豆素类药物(如华法林)合用,会使抗凝药的代谢减少,出血风险增加。
6.与奈福泮、曲马朵、碘海醇合用,会增加痫性发作发生风险。
7.与甲状腺素制剂合用, 易相互增强作用,引起心律失常,甚至产生毒性反应。。
8.与拟肾上腺素类药物合用,合用药物的升压作用被增强。

【禁忌症】
对TCAs过敏者、严重肝功能不全、青光眼、心肌梗死恢复期、甲状腺功能亢进、尿潴留、出现谵妄、躁狂的患者禁用。

【用法与用量】
由于剂型及规格不同,用法用量请仔细阅读药品说明书或遵医嘱。

Doxepin
Main use:panic disorder , obsessive-compulsive disorder , attention-deficit/hyperactivity disorder , enuresis (bed-wetting), eating disorders such as bulimia nervosa , cocaine dependency, and the depressive phase of bipolar (manic-depressive) disorder.
Active ingredient:doxepin hydrochlorid
 
How does it work?
Doxepin acts to change the balance of naturally occurring chemicals in the brain that regulate the transmission of nerve impulses between cells. Its action primarily increases the concentration of norepinephrine and serotonin (both chemicals that stimulate nerve cells) and, to a lesser extent, blocks the action of another brain chemical, acetylcholine.

Although not technically a tricyclic antidepressant, doxepin shares most of the properties of these drugs, which include amitriptyline , clomipramine , desipramine , imipramine , nortriptyline , protriptyline , and trimipramine . Studies comparing doxepin with these other drugs have shown that doxepin is no more or less effective than other antidepressants of its type. Its choice for treatment is as much a function of physician preference as any other factor.

The therapeutic effects of doxepin, like other antidepressants, appear slowly. Maximum benefit is often not evident for at least two weeks after starting the drug. People taking doxepin should be aware of this and continue taking the drug as directed even if they do not see immediate improvement.

What is it used for?
Treatment of panic disorder , obsessive-compulsive disorder , attention-deficit/hyperactivity disorder , enuresis (bed-wetting), eating disorders such as bulimia nervosa , cocaine dependency, and the depressive phase of bipolar (manic-depressive) disorder.

Warning!
As with tricyclic antidepressants, doxepin should be used cautiously and with close physician supervision in people, especially the elderly, who have benign prostatic hypertrophy, urinary retention, and glaucoma, especially angle-closure glaucoma (the most severe form). Before starting treatment, people with these conditions should discuss the relative risks and benefits of treatment with their doctors to help determine if doxepin is the right antidepressant for them.
A common problem with antidepressants is sedation (drowsiness, lack of physical and mental alertness). This side effect is especially noticeable early in therapy. In most patients, sedation decreases or disappears entirely with time, but until then, patients taking doxepin should not perform hazardous activities requiring mental alertness or coordination. The sedative effect is increased when doxepin is taken with other central nervous system depressants, such as alcoholic beverages, sleeping medications, other sedatives, or antihistamines. It may be dangerous to take doxepin in combination with these substances. Doxepin may increase the possibility of having seizures . Patients should tell their physician if they have a history of seizures, including seizures brought on by the abuse of drugs or alcohol. These people should use doxepin only with caution and be closely monitored by their physician.
Doxepin may increase heart rate and stress on the heart. It may be dangerous for people with cardiovascular disease, especially those who have recently had a heart attack, to take this drug or other antidepressants in the same pharmacological class. In rare cases where patients with cardiovascular disease must receive doxepin, they should be monitored closely for cardiac rhythm disturbances and signs of cardiac stress or damage. Doxepin should not be taken by nursing mothers because it is secreted into breast milk and may cause side effects in the nursing infant.

Side effects
Doxepin shares the side effects of tricyclic antidepressants. The most frequent of these are dry mouth, constipation, urinary retention, increased heart rate, sedation, irritability, dizziness, and decreased coordination. As with most side effects associated with tricyclic antidepressants, the intensity is highest at the beginning of therapy and tends to decrease with continued use. Dry mouth, if severe to the point of causing difficulty speaking or swallowing, may be managed by dosage reduction or temporary discontinuation of the drug. Patients may also chew sugarless gum or suck on sugarless candy in order to increase the flow of saliva. Some artificial saliva products may give temporary relief. Men with prostate enlargement who take doxepin may be especially likely to have problems with urinary retention. Symptoms include having difficulty starting a urine flow and more difficulty than usual passing urine. In most cases, urinary retention is managed with dose reduction or by switching to another type of antidepressant. In extreme cases, patients may require treatment with bethanechol, a drug that reverses this particular side effect. People who think they may be experiencing any side effects from this or any other medication should tell their physicians.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Interaction
Dangerously high blood pressure has resulted from the combination of antidepressants such as doxepin and members of another class of antidepressants known as monoamine oxidase (MAO) inhibitors. Because of this, doxepin should never be taken in combination with MAO inhibitors. Patients taking any MAO inhibitors, for example Nardil ( phenelzine sulfate) or Parmate ( tranylcypromine sulfate), should stop the MAO inhibitor then wait at least 14 days before starting doxepin or any tricyclic antidepressant. The same holds true when discontinuing doxepin and starting an MAO inhibitor. Doxepin may decrease the blood pressure–lowering effects of clonidine . Patients who take both drugs should be monitored for loss of blood-pressure control and the dose of clonidine increased as needed. The sedative effects of doxepin are increased by other central nervous system depressants such as alcohol, sedatives, sleeping medications, or medications used for other mental disorders such as schizophrenia . The anticholinergic effects of doxepin are additive with other anticholinergic drugs such as benztropine , biperiden , trihexyphenidyl , and antihistamines.

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 详细处方信息以本药内容附件PDF文件(2017101800461819.pdf)的“原文Priscribing Information”为准
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更新日期: 2017-10-10
附件:
2017101800461819.pdf    

 
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