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 详细处方信息以本药内容附件PDF文件（201261218432031.pdf）的“原文Priscribing Information”为准
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 部分中文萘普生钠处方资料（仅供参考）

中文药名: 萘普生钠片

药效类别: 消炎镇痛药

通用药名: NAPROXEN SODIUM

别　　名: Aleve, Anaprox, Antalgin, Apranax, Apronax, Danaprox, Femex, Flanax, Naprogesic, Naprosian, Naprosyn, Naxen, Nycopren, Synflex

化学名称: 2-Naphthalenacetic acid, 6-methoxy-α-methyl-, sodium salt

性状: 萘普生是一种2-芳基丙酸类（布洛芬）的非甾体抗炎药。白色或类白色结晶性粉末，几乎无臭。可在脂类物质中溶解，在水中几乎不溶。它的熔点是153 °C。

适应症
对类风湿性关节炎、骨关节炎、强直性脊椎炎、痛风、运动系统（如关节、肌肉及腱）的慢性变性疾病及轻、中度疼痛如痛经等，均有肯定疗效。

用法用量
口服：开始每日剂量５００～７５０ｍｇ，维持量每日３７５～７５０ｍｇ，分早晨及傍晚２次服用。轻、中度疼痛或痛经时，开始用５００ｍｇ，必需时经６～８小时后再服２５０ｍｇ，日剂量不得超过１２５０ｍｇ。
任何疑问，请遵医嘱！

副作用与警告
正如其他非甾体抗炎药一样，萘普生可以抑制钠和锂的代谢。服用该药的同时服用锂补剂时必须十分注意。萘普生等非甾体抗炎药也不应与水杨酸类药物(如阿司匹林) (因为药物会降低彼此疗效)或者与抗凝血剂 (会增加出血的风险)一起服用。萘普生钠药物不能让钠敏高血压患者服用，因为这会给患者带来潜在的发病危险。
2006年8月，Birth Defects Research杂志B刊[2]刊登了三个月孕龄内的孕妇服用了包括萘普生在内的非甾体抗炎药的研究结果，结果表明该类药物会增加胎儿先天缺陷的可能性，特别是先天心血管病。

注意事项
1.长期服用耐受良好，不良反应主要为胃肠道轻度和暂时不适。偶有恶心、呕吐、消化不良、便秘、胃肠道出血、失眠或嗜睡、头痛、头晕、耳鸣、瘙痒、皮疹、血管神经性水肿、视觉障碍及出血时间延长，一般不需中断治疗。
2.与乙酰水杨酸等非甾体抗炎药有交叉过敏反应，禁用于对本品及对乙酰水杨酸过敏的病人。
3.对伴有消化性溃疡或有消化性溃疡病史者慎用；对有活动性胃及十二指肠溃疡病人应在严格监督下使用。
4.本品可加强双香豆素的抗凝血作用。
5.与丙磺舒合用时，可增加本品的血药水平及明显延长本品的血药半衰期。

规格
片剂：每片２75ｍｇ。

Naprelan
(naproxen controlled-release)

DIN (Drug Identification Number)
02242505  NAPRELAN 375MG TABLET
02242506  NAPRELAN 500MG TABLET

How does Naprelan work? What will it do for me?
Naproxen controlled-release belongs to the class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to reduce the pain and swelling associated with rheumatoid arthritis and osteoarthritis. It works by reducing the amount of certain chemicals produced by your body that cause pain and swelling.

Naproxen controlled-release does not cure these conditions nor does it prevent these conditions from getting worse. The full effects of this medication are usually seen within 1 or 2 weeks.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use Naprelan?
The recommended starting dose of naproxen controlled-release is 750 mg taken once daily.

Your doctor may adjust your dose according to your response. The maximum daily dose is 1,500 mg. The lowest dose needed to control pain and inflammation should be used.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Naproxen controlled-release is best taken after a meal, or with food or milk. Do not lie down for about 15 minutes to 30 minutes after taking this medication. Swallow the tablets whole, and do not crush or chew them.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does Naprelan come in?
375 mg
Each white, capsule-shaped, film-coated, controlled-release tablet, debossed with "N" on one side, and "375" on the other, contains naproxen sodium 412.5 mg equivalent to naproxen 375 mg and sodium 37.5 mg. Nonmedicinal ingredients: ammonio methacrylate copolymer Type A, ammonio methacrylate copolymer Type B, citric acid, crospovidone, magnesium stearate, methacrylic acid copolymer Type A, microcrystalline cellulose, povidone, and talc; coating: hydroxypropyl methylcellulose, polyethylene glycol, and titanium dioxide.

500 mg
Each white, capsule-shaped, film-coated, controlled-release tablet, debossed with "N" on one side and "500" on the other, contains naproxen sodium 550 mg equivalent to naproxen 500 mg and sodium 50 mg. Nonmedicinal ingredients: ammonio methacrylate copolymer Type A, ammonio methacrylate copolymer Type B, citric acid, crospovidone, magnesium stearate, methacrylic acid copolymer Type A, microcrystalline cellulose, povidone, and talc; coating: hydroxypropyl methylcellulose, polyethylene glycol, and titanium dioxide.

Who should NOT take Naprelan?
Do not take this medication if you:
•are allergic to naproxen or any ingredients of the medication
•are breast-feeding
•are in the third trimester of pregnancy (after 28 weeks of pregnancy)
•are under 18 years of age
•have a bleeding disorder
•have a history of asthma, itchy skin rash, or allergic reactions after taking ASA (acetylsalicylic acid) or other nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, celecoxib, diclofenac, indomethacin, etc.)
•have active stomach bleeding such as gastric or duodenal ulcer, or have other types of bleeding from the stomach or intestines
•have bleeding in the brain
•have high blood potassium (hyperkalemia)
•have or have had inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis)
•have recently had heart bypass surgery
•have severe, uncontrolled heart failure
•have severely decreased liver function or active liver disease
•have severely decreased kidney function or worsening kidney disease

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 详细处方信息以本药内容附件PDF文件（201261218432031.pdf）的“原文Priscribing Information”为准
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