药品信息:
【药品类型】 皮肤用药
【中文名】 Desonide Cream
【功能主治】 适用于对皮质类固醇治疗有效的各种皮肤病，如接触性皮炎、神经性皮炎、脂溢性皮炎、湿疹、银屑病、扁平苔藓、单纯性苔藓、汗疱症等引起的皮肤炎症和皮肤瘙痒的治疗。
【药品性状】 本品为白色乳膏。
【药理作用】 药理作用本品为糖皮质激素类药物，具有抗炎、抗过敏、止痒及减少渗出作用；可以减轻和防止组织对炎症的反应，能消除局部非感染性炎症引起的发热、发红及肿胀，从而减轻炎症的表现；具有防止或抑制细胞免疫反应、抑制初次免疫应答的免疫抑制作用。毒理研究动物试验显示，家兔连续外涂地奈德乳膏12周可致肺和皮肤发生轻度可逆性感染，但停药后可完全恢复。
【药物相互作用】 肝药酶诱导剂如苯巴比妥、苯妥因钠等可使糖皮质激素的代谢加快。
【不良反应】 局部使用偶可引起灼热、瘙痒、刺激、皮肤干燥、毛囊炎、多毛症、痤疮样皮疹、色素脱失、口周炎、继发感染以及皮肤萎缩等。
【产品规格】 15g:7.5mg,10g:5mg
【药品成分】 本品主要成份为地奈德，其化学名称为:11β,21-二羟基-16α,17-[(1-甲基亚乙基)-二氧
【孕妇用药】 尚无充分的人体试验考察外用皮质激素的致畸效应，因此，孕妇应充分权衡利弊后慎用本品。孕妇不应大剂量，大面积长期使用此类药品。尚不知外用皮质激素是否泌入乳汁，但几乎不可能对婴儿造成不良影响，但哺乳期妇女仍应慎用本品。
【儿童用药】 儿童由于体表面积和体重的比值比成人更大，所以使用外用皮质激素治疗时发生下丘脑-垂体-肾上腺皮质轴(HPA)抑制和Cushing’s综合征的机率更大。儿童外用此类药品时应在有效前提下选择最低的剂量，长期使用此类药品可导致儿童生长发育迟缓。
【老年患者用药】 未进行该项实验且无可靠参考文献
【用法用量】 均匀涂搽于患处，每日2-4次。银屑病及其他顽固性皮肤病可采用封包治疗，若发生感染则应结束封包，并使用适当适当抗菌药物治疗。
【注意事项】 在部分患者中外用皮质激素的系统吸收可导致下丘脑-垂体-肾上腺皮质轴(HPA)功能可逆性的抑制，Cushing’s综合征、高血糖和糖尿。使用效果更强的皮质类固醇激素、大面积、长时间使用皮质类固醇激素治疗或采用封包治疗的患者，应定期检测尿游离皮质醇或ACTH释放试验来评估药物对HPA轴的抑制作用。如果出现HPA轴的抑制则应考虑停药，减少给药次数或换用作用较弱的皮质类固醇。儿童使用外用皮质激素的吸收率更高。
[Drug treatment of skin type]
[Chinese name] Desonide Cream
[Indications] applies to corticosteroid treatment is effective for a variety of skin diseases, such as contact dermatitis, neurodermatitis, seborrheic dermatitis, eczema, psoriasis, lichen planus, lichen simplex, sweat blisters caused psychosis skin inflammation and pruritus treatment.
[Drug Properties】 white cream.
Pharmacological effects of the pharmacological effects of Cymbalta glucocorticoid drugs, anti-inflammatory, anti-allergic, anti-itch and reduce leakage effects; can reduce and prevent tissue response to inflammation, and can eliminate the fever of local non-infectious inflammation , redness and swelling, thereby reducing the performance of the inflammation; preventing or suppressing the immune response cells, inhibition of the primary immune response to immunosuppression. Animal toxicology tests showed that rabbits treated with budesonide cream consecutive 12 weeks can cause mild reversible lung and skin infections, but can be fully restored after treatment.
Drug interactions hepatic drug metabolizing enzyme inducers such as phenobarbital, phenytoin metabolism of glucocorticoids can sodium accelerated.
Adverse reactions topical use can cause even burning, itching, irritation, dry skin, folliculitis, hirsutism, acne-like rash, hypopigmentation, perioral inflammation, infection, and skin atrophy.
[Product Specification] 15g: 7.5mg, 10g: 5mg
[Drug] the main ingredient ingredients budesonide, its chemical name: 11β, 21- dihydroxy -16α, 17 - [(1- methylethylidene) - dioxane
Pregnant drug] no adequate human trials investigated the teratogenic effects of topical corticosteroids, therefore, pregnant women should be fully weighed after careful using. Pregnant women should not be large doses, a large area of long-term use of these drugs. I do not know yet whether topical corticosteroids secreted into the milk, but almost impossible to cause adverse effects on the baby, but breast-feeding women should be careful using this.
Pediatric Use occur when children due to the ratio of body surface area and weight of greater than adults, so the use of topical corticosteroids in the hypothalamus - a greater chance of adrenal (HPA) axis suppression and Cushing's syndrome - pituitary. Children should be topical such drugs under the premise choose the lowest effective dose, long-term use of these drugs can lead to stunted growth of children.
[Elderly patients] did not conduct the experiment and no reliable references
Dosage uniform application may be in the affected area 2-4 times a day. Psoriasis and other skin diseases can be stubborn packet treatment, if an infection should end packet, and the appropriate use of appropriate antibiotic therapy.
[Note] In some patients with corticosteroids and foreign absorption systems can lead to hypothalamic - pituitary - adrenal axis (HPA) function reversible suppression, Cushing's syndrome, hyperglycemia and diabetes. The effect of a stronger use of corticosteroids, large area, long-term use in patients with corticosteroid therapy or the use of packet therapy should be monitored regularly urinary free cortisol or ACTH release assays to assess drug inhibition of the HPA axis. If HPA axis suppression discontinuation should be considered to reduce the frequency of administration, or switch to the role of the weaker corticosteroids. Children's use of topical corticosteroids higher absorption rate. |
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