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  药店国别: 澳大利亚药房
产地国家: 澳大利亚
所属类别: 皮肤科药物->皮肤感染
处方药:处方药
包装规格: 250毫克/片 12片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
利奥制药
生产厂家英文名:
Leo Pharma
该药品相关信息网址1:
http://en.wikipedia.org/wiki/Fusidic_acid
原产地英文商品名:
FUCIDINE 250mg/tab 12tabs/box
原产地英文药品名:
FUSIDIC ACID
中文参考商品译名:
立思丁 250毫克/片 12片/盒
中文参考药品译名:
夫西地酸
中文参考化合物名称:
反-16α-羧基-3β,11β-二羟基-4β,8β,14α-三甲基-18-去甲基-5β,10α-胆甾-(17Z)-17(20),24-二烯-21-酸半水合物
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Bacterial skin infections
英文适应病症2:
Skin infection
英文适应病症3:
Impetigo
英文适应病症4:
Boil
英文适应病症5:
Anti-inflammatory
临床试验期:
完成
中文适应病症参考翻译1:
细菌性皮肤感染
中文适应病症参考翻译2:
皮肤感染
中文适应病症参考翻译3:
脓疱病
中文适应病症参考翻译4:
疖肿
中文适应病症参考翻译5:
抗炎
药品信息:

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 详细处方信息以本药内容附件PDF文件(201121719245414.pdf)的“原文Priscribing Information”为准
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部分中文夫西地酸处方资料(仅供参考)

【商品名】立思丁

【中文名称】夫西地酸

【产品英文名称】Fusidic Acid

【生产企业】Leo Pharmaceutical Product Ltd.A/S

【功效主治】夫西地酸乳膏适用于各种细菌性皮肤感染,主要用于革兰氏阳性球菌引起的皮肤感染。如脓疱病,疖肿,毛囊炎,甲沟炎,须疮,汗腺炎,红癣,寻常痤疮,创伤合并感染,湿疹合并感染,溃疡合并感染等

【化学成分】夫西地酸。化学名称为:反-16α-羧基-3β,11β-二羟基-4β,8β,14α-三甲基-18-去甲基-5β,10α-胆甾-(17Z)-17(20),24-二烯-21-酸半水合物

【药理作用】夫西地酸是窄谱、高效的类甾体结构抗生素,其抗菌机制是通过抑制核糖体的易位来干扰延长因子G,阻止细菌蛋白的合成,这种独特的作用机制避免了与其他抗菌药物的交叉耐受性夫西地酸对与皮肤感染有关的各种革兰氏阳性球菌尤其对葡萄球菌高度敏感,对耐药金黄色葡萄球菌也有效,对某些革兰氏阴性菌也有一定的抗菌作用。与其它抗生素无交叉耐药性

【药物相互作用】局部用药尚无药物相互作用的相关报道

【不良反应】局部应用本品一般无副反应,偶尔会有轻微的刺激感,对腿部深度溃疡的治疗会伴有疼痛,但通常无需停药。罕见过敏反应。

【禁忌症】对药品过敏者。

【用法用量】本品应局部涂于患处,并缓和地摩擦;必要时可用多孔绷带包扎患处。每日二至三次,七天为一疗程,必要时可重复一个疗程

【贮藏方法】15~25℃密闭保存,置于儿童不易触及之处。

【注意事项】夫西地酸对眼结膜有刺激作用,尽量避免在眼睛周围使用;当治疗严重皮肤感染或顽固性皮肤疾病时,应辅助进行抗生素的全身用药;若发生严重刺激作用或出现过敏反应时,应停止用药并改用其它适当的药物治疗

Fucidine - General Information:
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Fucidin is effective against several bacterial species and used in the treatment of infections such as impetigo (characterised by blistering and yellowish-brown crusting of the skin), whitlow (paronchya) and inflammation of hair follicles (sycosis). It is also used to treat eczema or dermatitis that has become infected.

Fucidine Indication: For the treatment of bacterial infections.

Mechanism Of Action: Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome.

Drug Interactions: Amprenavir The protease inhibitor increases the effect and toxicity of fusidic acid
Fosamprenavir The protease inhibitor increases the effect and toxicity of fusidic acid
Nelfinavir The protease inhibitor increases the effect and toxicity of fusidic acid
Ritonavir The protease inhibitor increases the effect and toxicity of fusidic acid
Saquinavir The protease inhibitor increases the effect and toxicity of fusidic acid
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Simvastatin Increased risk of myopathy/rhabdomyolysis
Indinavir Indinavir increases the effect and toxicity of fusidic acid

Food Interactions: Take with food to reduce irritation.

Generic Name: Fusidic Acid

Synonyms: Diethanolamine fusidate; Fucidic acid; Fusidate; Fusidate Sodium; Fucidate Sodium; Fucidate

Drug Category: Antibacterial Agents

Drug Type: Small Molecule; Approved

Other Brand Names containing Fusidic Acid: Fucidin Cream 2%; Fucithalmic; Fusidine; Ramycin; Fucidin; Fucidin acid; Fucidine;

Absorption: Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.

Toxicity (Overdose): Not Available

Protein Binding: 97 to 99%

Biotransformation: Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.

Half Life: Approximately 5 to 6 hours in adults.

Dosage Forms of Fucidine: Not Available

Chemical IUPAC Name: (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid

Chemical Formula: C31H48O6

Organisms Affected: Enteric bacteria and other eubacteria

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 详细处方信息以本药内容附件PDF文件(201121719245414.pdf)的“原文Priscribing Information”为准
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更新日期: 2014-06-29
附件:
 
调控比例: 100%
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