药品信息: 中文别名: 乙酰螺旋霉素、醋酸螺旋霉素
英文别名:
生产企业:
药品类别: 大环内酯类抗生素
药理药动
抗菌谱近似红霉素,对葡萄球菌、化脓性链球菌、肺炎链球菌、脑膜炎球菌、淋球菌、白喉杆菌、支原体、梅毒螺旋体等有抗菌作用。口服100mg或200mg,于2小时血药浓度达峰,分别为0.8μg/ml和1μg/ml。体内分布以肺脏、肝脏较多, 胆汁中浓度可达血清浓度的7-10倍,尿液中排泄甚少。本品不能透过正常人的血脑障。
适 应 症
适用于葡萄球菌、化脓性链球菌、肺炎链球菌、脑膜炎球菌、淋球菌、白喉杆菌、支原体、梅毒螺旋体等敏感菌所致的扁桃体炎、支气管炎、肺炎、咽炎、中耳炎、皮肤和软组织感染、乳腺炎、胆囊炎、猩红热、牙科和眼科感染等。
用法用量
口服,一次0.2g,一日4-6次.重症可至一日1.6-2g.儿童一日每公斤体重30mg,分4-6次给药.本品受胃酸影响轻,饭后服.
不良反应
个别病例可引起胃肠道反应:恶心,呕吐,食欲不振,腹胀,腹泻.可有白细胞减少. 大剂量使用时可引起血尿.也有过敏反应,皮炎,紫癜的病例.血清氨基转移酶升高者偶见。
Chinese alias : Acetylspiramycin acetate spiramycin
English Name :
Manufacturer:
Drug Category: macrolide antibiotics
Pharmacology, Pharmacokinetics
Antibacterial spectrum similar to erythromycin, Staphylococcus aureus , Streptococcus pyogenes , Streptococcus pneumoniae, meningitis , Neisseria gonorrhoeae , diphtheria , mycoplasma, Treponema pallidum , which are antibacterial effect. Oral 100mg or 200mg, in two hours peak plasma concentration were 0.8μg/ml and 1μg/ml. Biodistribution in lung, liver more bile concentrations of up to 7-10 times the concentration in serum , urine excretion little . This product is not through the normal blood-brain barrier.
Indications
Suitable for Staphylococcus aureus, Streptococcus pyogenes , Streptococcus pneumoniae, meningitis , Neisseria gonorrhoeae , diphtheria , mycoplasma , Treponema pallidum caused by susceptible strains such as tonsillitis, bronchitis , pneumonia, pharyngitis , otitis media , skin and soft tissue infections , mastitis, cholecystitis , scarlet fever , dental and eye infections.
Dosage
Orally, 0.2g, 4-6 times a day . Severe can to 1 1.6-2g. Kilogram of body weight per day for children 30mg, points 4-6 doses. This product is affected by mild acid , after meals.
Adverse reactions
Individual cases can cause gastrointestinal reactions : .. nausea, vomiting, loss of appetite , bloating , diarrhea, leukopenia may have large doses can cause hematuria use also have allergic reactions , dermatitis, purpura patients with elevated serum aminotransferase occasionally.