部分中文舒林酸信息资料（仅供参考）
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 详细处方信息以本药内容附件PDF文件（200961100170712.pdf）的“原文Priscribing Information”为准
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    【注意事项】 常见消化道反应。 
    【药理毒理】本品为非甾体炎抗炎药，口服吸收后在体内代谢转化为硫化物，该硫化物才具有显著的消炎和镇痛作用，对胃肠道刺激性较小本品还能抑制5-羟色胺的释放，以及抑制胶原诱发的血小板聚集作用，延长出血时间 
    【药 动 学】口服后约90%被吸收，t1/2为7h～8h，代谢物的t1/2为16h～18h。 
    【适 应 证】风湿性关节炎、类风湿性关节炎、强直性脊柱炎、骨关节炎等，也用于滑囊炎、腱鞘炎和急性痛风性关节炎的短程治疗。 
    【不良反应】常见恶心、呕吐、便秘、腹痛等，偶见胃出血、眩晕、头痛、皮疹、瘙痒及发热等。 
    【相互作用】与阿司匹林并用降低本品的硫化代谢物，降低疗效；能增强甲氨蝶呤、环孢素的毒性。 
    【用法用量】口服，与食物同时服，关节炎、强直性脊柱炎100mg～200mg/次，2次/日，7日为1疗程；幼年型类风湿性关节炎开始每日4.5mg/kg，分2次服，必要时可增至每日6mg/kg，维持量每日4.5mg～6mg/日。 
    【注意事项】妊娠期B类（分娩期D类）。活动性胃肠道出血患者及对阿斯匹林过敏者禁用，肝功能异常、肾结石者及孕妇、哺乳期妇女和2岁以下婴幼儿慎用。

CLINORIL is indicated for acute or long-term use in the relief of signs and symptoms of the following:. Osteoarthritis; Rheumatoid arthritis2; Ankylosing spondylitis; Acute painful shoulder 
DRUG CLASS AND MECHANISM: Sulindac is a nonsteroidal antiinflammatory drug (NSAID). Other NSAIDs include ibuprofen (Motrin), indomethacin (Indocin), nabumetone (Relafen) and several others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Sulindac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Sulindac was approved by the FDA in September 1978. 
STORAGE: Sulndac should be stored in a sealed container and protected from moisture at room temperature, 15-30 C (59-86 F). 
DOSING: The usual adult dose is 150 or 200 mg given twice daily with meals. The maximum dose is 400 mg daily. 
DRUG INTERACTIONS: Sulindac may increase the blood levels of lithium (Eskalith) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity. 
Sulindac may reduce the blood pressure lowering effects of blood pressure medications. This may occur because prostaglandins play a role in the regulation (reduction) of blood pressure. 
When sulindac is used in combination with methotrexate or aminoglycoside antibiotics (for example, gentamicin) the blood levels of methotrexate or aminoglycoside may increase, presumably because the elimination of methotrexate or aminoglycosides from the body is reduced. This may lead to more methotrexate- or aminoglycoside-related side effects. 
Individuals taking oral blood thinners or anticoagulants, for example, warfarin, (Coumadin), should avoid sulindac because sulindac also thins the blood, and excessive blood thinning may lead to bleeding. 
Persons who consume more than three alcoholic beverages per day are at increased risk of developing stomach ulcers when taking sulindac or other NSAIDs. 
SIDE EFFECTS: Most patients benefit from sulindac and other NSAIDs with few side effects. However, serious side effects can occur and generally tend to be dose related, that is occur more frequently with higher doses. Therefore, it is advisable to use the lowest effective dose to minimize side effects. The most common side effects of sulindac involve the gastrointestinal system. It can cause ulcerations of the stomach and small intestine, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding and liver toxicity. Sometimes, ulceration of the stomach and bleeding can occur without any abdominal pain, and black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears, and lightheadedness also can occur. 
Sulindac should be avoided by patients with a history of exacerbation of asthma, hives, or other allergic reactions to aspirin or other NSAIDs. Rare but severe allergic reactions have been reported in such individuals. It also should be avoided by patients with peptic ulcer disease or poor kidney function, since this medication can aggravate both conditions. Fluid retention, blood clots, heart attacks, hypertension, and heart failure have also been associated with the use of NSAIDs.

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 详细处方信息以本药内容附件PDF文件（200961100170712.pdf）的“原文Priscribing Information”为准
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