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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->抗抑郁药
处方药:处方药
包装规格: 5毫克/片 30片/盒
计价单位:
   
生产厂家中文参考译名:
武田
生产厂家英文名:
Takeda
该药品相关信息网址1:
http://us.brintellix.com/?gclid=CNKE_rbuwLwCFUVlfgoddDMACA
原产地英文商品名:
Trintellix 5mg 30 Tablets
原产地英文药品名:
VORTIOXETINE
中文参考商品译名:
Trintellix (Brintellix® 药名已改为Trintellix) 5毫克/片 30片/盒
中文参考药品译名:
沃替西汀
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Depression
临床试验期:
完成
中文适应病症参考翻译1:
抑郁
药品信息:
丹麦灵北及在美国合作伙伴日本武田制药公司的新兴抗抑郁药沃替西汀(英文商品名:Brintellix, 英文通用名:Vortioxetine)于2013年9月30日获美国食品药品管理局(FDA)批准用于治疗成年人重度抑郁症(MDD)。 沃替西汀(Vortioxetine)属于新一代抗抑郁药。该药被认为通过2种作用机制的联合发挥作用:受体活性调节和再摄取抑制(reuptake inhibition)。体外研究表明,vortioxetine是5-HT3和5-HT7受体拮抗剂、5-HT1B受体部分激动剂、5-HT1A受体激动剂、5-羟色胺转运蛋白(SERT)抑制剂. 1998年9月灵北在美国的合作伙伴森林实验室(Forest Laboratories)的西酞普兰(Citalopram, Cipramil)获得FDA批准,商品名为Celexa(喜普妙)。2002年8月14日,森林实验室的草酸艾司西酞普兰(Escitalopram, (S)-citalopram,Cipralex)获得FDA批准,商品名为Lexapro(来士普),森林实验室采取了替代喜普妙的推广策略。 沃替西汀(Brintellix,Vortioxetine)的上市,将有助于抵消丹麦第二大制药商灵北(Lundbeck)另一种抗抑郁药来士普(Lexapro)销售的下降,在美国,来士普(Lexapro)2012年3月失去专利保护。2011年,来士普位居美国处方药排名第16位,处方量达到2370.7万张,销售额为21.31亿美元。2012年受到仿制药冲击,该药全球销售额下降至21亿美元。 2012年3月14日,梯瓦制药、IVAX制药获得FDA批准上市销售规格为5mg、10mg和20mg的仿制药艾司西酞普兰,其中,梯瓦获得了180天的独家仿制药权。在中国,2005年,丹麦灵北的草酸艾司西酞普兰获准进口,商品名为来士普(Lexapro),分包装企业为西安杨森制药有限公司。2008年,山东京卫制药有限公司首家获得草酸艾司西酞普兰的生产批文,商品名为百适可。此后,四川科伦大药厂也获得了生产批文,商品名为百洛特。今年10月,康恩贝3.1类新药草酸艾司西酞普兰片也获批生产。 全球领先的制药与医疗保健问题研究和咨询公司——决策资源公司(Decision Resources)8月初发布报告预测,到2022年,抗抑郁新药Brintellix在美国、法国、德国、意大利、西班牙、英国、日本市场中将成为重磅药物。根据迄今取得的数据,鉴于其对认知的积极影响及可耐受的副作用属性,Brintellix预计将成为单相抑郁症市场中最成功的新药。Decision Resources预计,灵北和武田将把Brintellix定位为老年抑郁症患者的一线治疗选择,并作为对常用选择性5-羟色胺再摄取抑制剂(SSRI)治疗无效的患者的二线治疗选择。 商品名:Brintellix 通用名:Vortioxetine 别名:Lu AA21004 中文名:沃替西汀 CAS 登录号:508233-74-7 中文化学名:1-[2-(2,4-甲基苯硫基)苯基]哌嗪 英文化学名:1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine 适应症:重度抑郁症 作用机理:5-HT3和5-HT7受体拮抗剂、5-HT1B受体部分激动剂、5-HT1A受体激动剂、5-羟色胺转运蛋白(SERT)抑制剂. 药物分类:选择性血清素再摄取抑制剂(选择性5-羟色胺再摄取抑制剂,SSRIs) 批准时间:2013年9月30日 (美国), 2013年12月27日 (欧盟) 美国专利号码: 7144884 (下载此专利), 8476279(下载此专利) 相关中国专利:CN1319958 C (下载此专利), CN1561336 A; CN1319958C, CN1561336A 专利有效期: 2023年1月9日(美国专利号:7144884),2022年10月2日(美国专利号:8476279) 年销售峰值(预计): 20亿美元 药物公司:灵北(Lundbeck), 武田(Takeda) Do not take BRINTELLIX if you: Are allergic to vortioxetine or any of the ingredients in BRINTELLIX Take a Monoamine Oxidase Inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI, including the antibiotic linezolid; do not take an MAOI within 21 days of stopping BRINTELLIX; do not start BRINTELLIX if you stopped taking an MAOI in the last 14 days BRINTELLIX may cause serious side effects including: Serotonin Syndrome: A potentially life-threatening problem that can happen when medicines such as BRINTELLIX are taken with certain other medicines. Symptoms may include agitation, hallucinations, coma or other changes in mental status; problems controlling movements or muscle twitching, stiffness or tightness; fast heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting or diarrhea. Abnormal bleeding or bruising: BRINTELLIX and other serotonergic antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin. Manic episode: Symptoms may include greatly increased energy; severe trouble sleeping; racing thoughts; reckless behavior; unusually grand ideas; excessive happiness or irritability; talking more or faster than usual. Low salt (sodium) levels in the blood: Symptoms may include headache; difficulty concentrating, memory changes or confusion; weakness and unsteadiness on your feet and in severe or sudden cases hallucinations, fainting, seizures or coma. If not treated, severe low sodium levels can cause death. Before starting BRINTELLIX, tell your healthcare provider if you have or had liver problems, seizures or convulsions, bipolar disorder (manic depression) or mania, low salt (sodium) levels in your blood, bleeding problems, drink alcohol, have any other medical conditions or if you are pregnant, nursing, plan to become pregnant, or plan to nurse. BRINTELLIX and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together. Tell your healthcare provider if you plan on or are taking any other prescription and non-prescription medicines, vitamins and herbal supplements including medicines for migraine headaches, such as triptans; medicines used to treat mood, anxiety, psychotic or thought disorders such as tricyclics, lithium, SSRIs, SNRIs, bupropion, buspirone or antipsychotics; MAOIs including linezolid (a specific antibiotic); over-the-counter supplements such as tryptophan or St. John's wort; and the following medicines: aspirin, NSAIDs, warfarin (Coumadin®, Jantoven®), diuretics, rifampicin, carbamazepine, phenytoin, quinidine, tramadol or fentanyl. Common side effects of BRINTELLIX include: nausea, constipation or vomiting. These are not all the possible side effects of BRINTELLIX. Do not start or stop taking BRINTELLIX without talking to your healthcare provider first. Suddenly stopping BRINTELLIX when you take higher doses may cause you to have side effects including headache, stiff muscles, mood swings, sudden outbursts or anger, dizziness or feeling lightheaded, or runny nose. Until you know how BRINTELLIX affects you, do not drive, operate heavy machinery or engage in other dangerous activities. Avoid drinking alcohol while taking BRINTELLIX. Talk to your healthcare provider. 注明:美国生产商Takeda 将Brintellix® 药名已改为Trintellix. Note: The product name of Brintellix has been changed to Trintellix by US Pharmaceutical Manufacturer Takeda
更新日期: 2016-08-11
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