药品信息:
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(201412118502910.pdf)的“原文Priscribing Information”为准 --------------------------------------------------------------- 部分中文Kentera处方资料(仅供参考)
中文别名: 奥昔布宁、氯化羟丁宁、尿多灵
英文别名: Ditropan、Oxibutinina Hydrochloride、Oxybutynin Chloride、Oxybutynine、Pasmonul
本品为一种主要作用于副交感神经系统的药物。具有很强的平滑肌解痉作用,较强的镇痛作用,较弱的抗胆碱能作用及局部麻醉作用。其解痉作用比阿托品强4~10倍,而抗胆碱作用仅为其五分之一。
药动学
口服吸收迅速而完全。给药后30min起效,血药浓度达峰时间小于1h,消除半减期约2.3h。本品主要由肝脏代谢后经尿排出,在体内几乎无蓄积。
适 应 症
用于治疗尿急、尿频、尿失禁、夜间遗尿等疾病。对膀胱炎、尿道炎及复发性的尿道感染所引起的尿频症状最为适合。对治疗小儿遗尿也有较好的疗效。
用法用量
不良反应
服药后有口干现象,继续服用数日后口干自然消失。一般不良反应为视力模糊、出汗减少、乏力、头晕及胃肠道反应,但多数能耐受。
相关英文资料
禁忌症
青光眼、幽门及十二指肠阻塞、阻塞性小肠损害或绞痛、胃肠道出血及阻塞性的尿道疾患禁用,老年患者、肝肾功能不全者及反流性食管炎引起的食管裂空疝者镇用。
Kentera - Indications: urinary incontinence
Kentera is indicated for the relief of symptoms of bladder instability associated with voiding in patients with neurogenic bladder i.e.: urgency, frequency, leakage, incontinence and dysuria.
Kentera patches contain the active ingredient oxybutynin hydrochloride, which is a type of medicine called an anticholinergic (or antimuscarinic) muscle relaxant. It works by relaxing the involuntary muscle that is found in the wall of the bladder.
The muscle in the wall of the bladder is called the detrusor muscle. It can sometimes contract in uncontrollable spasms, and this is often referred to as having an overactive or unstable bladder. The overactive detrusor muscle can cause an increase in the number of times you need to pass urine, uncontrollable urges to pass urine, or involuntary leakage of urine (urinary incontinence).
Oxybutynin works by relaxing the detrusor muscle in the wall of the bladder. It does this by blocking receptors called cholinergic (or muscarinic) receptors that are found on the surface of the muscle cells. This prevents a natural body chemical called acetylcholine from acting on these receptors.
Normally when acetylcholine acts on these receptors, it causes the detrusor muscle to contract and the bladder to empty. By blocking acetylcholine, oxybutynin helps the muscle in the bladder wall to relax. This reduces unstable, involuntary contractions of the bladder, and thereby increases the capacity of the bladder to hold urine. In turn, this reduces the need to pass urine.
Oxybutynin is used to treat urinary frequency, urinary urgency and incontinence in people with unstable bladders. The condition may have no known cause (idiopathic bladder instability), or may be due to problems with the nerve supply to the bladder (neurogenic bladder), for example following a spinal cord injury, or as a result of conditions affecting the nervous system such as spina bifida or multiple sclerosis.
Kentera patches are applied to the skin of the hip, abdomen or buttock. The oxybutynin is steadily absorbed from the patch through the skin into the bloodstream. The patches are designed to be changed twice a week (every three to four days). |